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FRISC: The Faculty Research Interests Science Comparator |
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Associate Professor of Pharmacology
Molecular Biophysics
Neuroscience
Office: (214) 648-3200
FAX: (214) 648-2971
We study two aspects of membrane protein trafficking: 1) The function
of dynamin, a GTPase required for receptor-mediated endocytosis and secutory vesicle
recycling, and its regulation by phosphorylation and phospholipid binding; 2) The role of
an actin-activated ATPase, myosin I b , in the lateral
translocation of proteins within the plasma membrane.
Our current focus is on the clustering of T cell receptors and associated
proteins during lymphocyte stimulation.
Selected
Publications:
Achiriloaie, M., Barylko, B., and Albanesi, J.P. (1999) Essential
Role of the Dynamin Pleckstrin Homology Domain in Receptor-Mediated Endocytosis. Mol.Cell.Biol., 19:1410-1415
Binns, D.D., Barylko, B., Grichine, N., Atkinson, M.A.L., Helsm,
M.K., Jameson, D.M., Eccleston, J.F., and Albanesi, J.P. (1999) Correlation Between
Self-Association Modes and GTPase Activation of Dynamin. J.Prot.Chem., 18:277-290
Barylko, B., Binns, D., Lin, K-M., Atkinson, M.A.L., Jameson, D.M.,
Yin, H.L., and Albanesi, J.P. (1998) Synergistic Activation of Dynamin GTPase by Grb2 and
Phosphoinositides. J.Biol.Chem.,
273:3791-3797
Lin, H.C., Barylko, B., Achiriloaie, M., and Albanesi, J.P. (1997)
Phosphatidylinositol (4,5)-Bisphosphate-dependent Activation of Dynamins I and II Lacking
the Proline/Arginine-rich Domains. J.Biol.Chem.,
272:25999-26004
Reizes, O., Barylko, B., Li, C., Südhof, T.C., and Albanesi, J.P.
(1994) Domain structure of a mammalian myosin I b (MMIB). Proc. Natl. Acad. Sci. U.S.A., 91:6349-6353.
Wagner, M.C., Barylko, B., and Albanesi, J.P. (1992) Tissue
distribution and subcellular localization of mammalian myosin I. J. Cell Biol., 119:163-170.
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Last updated: 17 Nov 2000
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted keyword count
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Database: Medline abstracts (1967 - Present)
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Results computed on: 6/9/2006