 |
FRISC: The Faculty Research Interests Science Comparator |
|
Professor of Internal Medicine
Integrative
Biology
Office: 214-648- 2509
FAX: 214-648- 8955
Email: robert.alpern@email.swmed.edu
The Na/H antiporter isoform, NHE-3, mediates the transport of sodium from the lumen
into the proximal tubule cell in exchange for extrusion of hydrogen ions. This transporter
mediates the majority of renal NaCl and NaHCO 3 reabsorption, and thus plays a
pivotal role in the regulation of extracellular fluid volume, blood pressure, and blood
pH. Our laboratory studies the acute and chronic regulation of NHE-3 by hormones such as
angiotensin II, autocrine/paracrine factors such as endothelin, blood pH, and blood
osmolality. Regulation is studied at the level of gene expression, protein synthesis and
stability, trafficking, and phosphorylation, in cultured renal epithelial cells and in
intact animals. The role of tyrosine kinase pathways and MAP kinases as regulators of
NHE-3 is addressed. Knockout mice are used to examine the role of these regulatory
mechanisms in volume and acid-base homeostasis.
Selected Publications:
Peng Y, Moe OW, Chu T-S, Preisig PA, Yanigasawa M, and Alpern RJ ET B
Receptor Activation Leads to Activation and Phosphorylation of NHE3. Am J Physiol 276:C938-C945
(1999)
Ambühl PM, Yang X, Peng Y, Preisig, PA, Moe OW, and Alpern RJ Glucocorticoids Enhance
Acid Activation of the Na + /H + Exchanger 3 (NHE3). J Clin Invest
103:429-435 (1999)
Ambühl PM, Amemiya M, Preisig, PA, Moe OW, and Alpern RJ Chronic Hyperosmolality
Increases NHE3 Activity in OKP Cells. J Clin Invest 101:170-177 (1998)
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
-
Similarity Method: Weighted keyword count
-
Database: Medline abstracts (1967 - Present)
-
Publication Type: All
-
Score Calculation Method: Cosine Similarity Method
-
Sort by: Score
-
Show: Top 100 hits
-
Results computed on: 6/9/2006