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FRISC: The Faculty Research Interests Science Comparator |
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Professor of Cell Biology
Cell Regulation
Office: (214) 648-2765
FAX: (214) 648-7577
Email: anders06@utsw.swmed.edu
Caveolae are a cell surface specialization that were discovered over 40 years ago. The
modern era of caveolae research was ushered in by two discoveries; 1) receptor-mediated
uptake of folate by caveolae (2) 35004600300037003500300035004100300030003700410041003300360038003500360031003000300030003000380033003200430046003600350036004500370032003600360030003000420033004500460046004500300031003000300030003300430039003400380030003200300030003000300030003000300033003000300030003000300030004500380030003200300030003000300030003000310036003500420034003100360045003600340036003500370032003700330036004600360045003200430032003000330031003300390033003900330032003200300032003300330036003300300033003500350044003000300030004500300030003000300030003000 ,
and 2) caveolin, the first marker protein for caveolae (6) 32003800410034003900460035004100300030003700410041003300360038003500360031003000300030003000380033003200430046003600350036004500370032003600360030003000420033004500460046004500300031003000300030003300430039003400440030003200300030003000300030003000300033003000300030003000300030004500300030003200300030003000300030003000310036003500420035003200360046003700340036003800360032003600350037003200360037003200430032003000330031003300390033003900330032003200300032003300330036003300330033003000350044003000300030004500300030003000300030003000 . The first discovery provided a
general model for how caveolae might function in diverse cell types while caveolin was the
critical tool needed to purify this membrane domain for analysis. Purified caveolae not
only yielded information about their chemical composition but also the unexpected finding
they are rich in a variety of cell signaling molecules. Subsequently, specific signaling
events have been mapped to this domain (4, 5) 43003200330033004600380031003300300030003900380041003300360038003500360031003000300030003000380033003200430046003600350036004500370032003600360030003000420033004500460046004500300031003000300030003300430039003400460030003200300030003000300030003000300036003000300030003000300037003800300030003200300030003000300030003000320035003500420034004400360039003600450036003500360046003200430032003000330031003300390033003900330038003200300032003300330031003300340033003900330035003300420032003000340043003600390037003500320043003200300033003100330039003300390033003700320030003200330033003100330034003300340033003900350044003000300030004500300030003000300030003000 , indicating they play a major
role in signal transduction. In addition, caveolin appears to mediate the influx and
efflux of cellular cholesterol through caveolae (7) 4500370046003600430046004500330030003000370036004100330036003800350036003100300030003000300038003300320043004600360035003600450037003200360036003000300042003300450046004600450030003100300030003000330043003900350032003000320030003000300030003000300030003300300030003000300030003000450032003000320030003000300030003000300031003400350042003500330036004400360031003700320037003400320043003200300033003100330039003300390033003600320030003200330033003100330031003300340033003000350044003000300030004500300030003000300030003000 . Maintaining the proper level of
cholesterol in caveolae turns out to be critical for proper signal transduction (3) 37003000420042004400430036004500300030003700410041003300360038003500360031003000300030003000380033003200430046003600350036004500370032003600360030003000420033004500460046004500300031003000300030003300430039003500340030003200300030003000300030003000300033003000300030003000300030004500410030003200300030003000300030003000310036003500420034003600370035003700320037003500360033003600380036003900320043003200300033003100330039003300390033003800320030003200330033003100330035003300310033003100350044003000300030004500300030003000300030003000 . Caveolae are the target for
multiple disease processes, including viruses, parasitic diseases, cancer, heart disease
and prion-induced encephalopathies (1) 4600410044004100370042003200380030003000370043004100330036003800350036003100300030003000300038003300320043004600360035003600450037003200360036003000300042003300450046004600450030003100300030003000330043003900350036003000320030003000300030003000300030003300300030003000300030003000450045003000320030003000300030003000300031003700350042003400310036004500360034003600350037003200370033003600460036004500320043003200300033003100330039003300390033003800320030003200330033003100330033003300380033003400350044003000300030004500300030003000300030003000 .
Current research in the laboratory is focused on understanding at the molecular level how
caveolae, as well as other membrane domains, compartmentalize signal transduction, thereby
facilitating the integration of nutritional, mechanical and humoral information at the
cell surface.
Selected Publications:
ADDIN ENBbu 1. Anderson, R. G. W. 1998. The caveolae membrane system. Annu. Rev. Biochem. 67:199-225.
2. Anderson, R. G. W., B. A. Kamen, K. G. Rothberg, and S. W. Lacey.
1992. Potocytosis: sequestration and transport of small molecules by caveolae. Science . 255:410-411.
3. Furuchi, T., and R. G. Anderson. 1998. Cholesterol depletion of
caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J Biol Chem . 273:21099-104.
4. Liu, P., Y.-S. Ying, and R. G. W. Anderson. 1997. Platelet-derived
growth factor activates mitogen-activated protein kinase in isolated caveolae. Proc. Natl. Acad. Sci. USA . 94:13666-13670.
5. Mineo, C., Y. S. Ying, C. Chapline, S. Jaken, and R. G. Anderson.
1998. Targeting of protein kinase Calpha to caveolae. J Cell Biol . 141:601-10.
6. Rothberg, K. G., J. E. Heuser, W. C. Donzell, Y.-S. Ying, J. R.
Glenney, and R. G. W. Anderson. 1992. Caveolin, a protein component of caveolae membrane
coats. Cell . 68:673-682.
7. Smart, E. J., Y.-S. Ying, W. C. Donzell, and R. G. W. Anderson. 1996. A role for
caveolin in transport of cholesterol from ER to plasma membrane. J. Biol. Chem. 271:29427-29435. 380044003300420032003900410043003000300034003200410033003600380035003600310030003000300030003800330032004300460036003500360045003600320036003200300030004200330045004600460045003000370030003000300033004300410039004200300032003000300030003000300034003600460030003500320037004400450042004300300030003000300030003000
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Robertson
Last updated: 17 Nov 2000
Extraction Method: Expand using Medical Synonyms-
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