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FRISC: The Faculty Research Interests Science Comparator |
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Assistant Professor of Obstetrics and Gynecology and Biochemistry
Biological
Chemistry
Office: (214) 648-4792
FAX: (214) 648-8683
Email: stefan.andersson@utsouthwestern.edu
17 b -Hydroxysteroid dehydrogenases are enzymes involved in
both the activation and inactivation of androgens and estrogens. Reduction at carbon 17 of
steroid substrates increases their affinity for the cognate nuclear receptor, whereas
oxidation of the substrates at this position decreases and thus inactivates steroids as
receptor ligands. In general, gonadal tissues reduce androgens and estrogens, whereas
extragonadal tissues oxidize these substrates. We have isolated and characterized cDNAs
and genes that encode two distinct isozymes of 17 b -hydroxysteroid
dehydrogenase, designated 17 b -hydroxysteroid dehydrogenase type
2 and type 3. The isozymes have different biochemical properties and tissue distributions.
Mutations in the 17 b -hydroxysteroid dehydrogenase 3 gene, which
impair formation of testosterone in the fetal testis, give rise to a form of human male
pseudohermaphroditism termed 17 b -hydroxysteroid dehydrogenase
deficiency. Our major research effort is directed at gaining insight into the
biochemistry, function, and physiological roles of the different 17 b -hydroxysteroid
dehydrogenases.
We are also interested in the mechanism by which plant carotenoids are being
converted to vitamin A in man. The intestinal enzyme carotene dioxygenase
catalyzes the first step in this pathway, and thus, is crucial for the
utilization of provtamin A carotenoids as a dietary source of vitamin A. We have
recently developed molecular genetic and biochemical tools to study the human
carotene dioxygenase gene and protein. Our goal is to understand at the
molecular level how carotene dioxygenase influences vitamin A homeostasis
Selected Publications:
Lindqvist A, Hughes IA, and Andersson S (2001)
Substitution mutation C268Y causes 17 b -hydroxysteroid
dehydrogenase 3 deficiency. J
Clin Endocrinol Metab 86:921-923
Moghrabi N, and Andersson S (1998) 17 b -Hydroxysteroid
dehydrogenases: Physiological roles in health and disease. Trends Endocrinol Metab 9:265-27
Moghrabi N, Hughes IA, Dunaif A, and Andersson S (1998) Deleterious
missense mutations and silent polymorphism in the human 17 b -hydroxysteroid
dehydrogenase 3 gene. J
Clin Endocrinol Metab 83:2855-2860
Geissler WM, Davis DL, Wu L, Bradshaw
KD, Patel S, Mendonca BB, Elliston KO, Wilson
JD, Russell DW, and Andersson S (1994) Male pseudohermaphroditism caused by mutations
of testicular 17 b -hydroxysteroid
dehydrogenase 3. Nature Genetics 7:34-39
Casey ML, MacDonald PC, and Andersson S (1994) 17 b -Hydroxysteroid
dehydrogenase type 2: chromosomal assignment and progestin regulation of gene
expression in human endometrium. J Clin
Invest 94:2135-2141
Wu L, Einstein M, Geissler WM, Chan HK, Elliston
KO, and Andersson S (1993) Expression cloning and characterization of human 17 b -hydroxysteroid dehydrogenase type 2, a microsomal
enzyme possessing 20 a -hydroxysteroid dehydrogenase activity. J
Biol Chem 169:12964-12969
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted keyword count
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Database: Medline abstracts (1967 - Present)
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Sort by: Score
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Show: Top 100 hits
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Results computed on: 6/9/2006