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FRISC: The Faculty Research Interests Science Comparator |
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Professor of Dermatology
Immunology
Office: 214-648-2969
FAX: 214-648-9292
Email: bergstre@utsw.swmed.edu
Departmental Home Page: http://www.swmed.edu/home_pages/derma/
Two populations of dendritic leukocytes populate the epidermis of murine
skin, Langerhans cells and dendritic epidermal T cells. Our investigative efforts are
evenly divided between these two highly related subjects. LC are resident epithelial
antigen presenting cells of dendritic cell lineage. Previous studies have revealed that
modest fluences of ultraviolet radiation have the capacity to interrupt their
antigen-presenting function such that tolerance rather than hypersensitivity is induced.
Our current work concerns methods of long-term culture and mechanisms of photon absorption
and gene activation in LC, as well as in supporting keratinocytes. On the other hand,
DETC, which express both Thy-1 antigen and g d T cell receptors,
are a member of the recently defined family of resident epithelial g d T cells. DETC, however, have been distinguished from g d T cells in other tissues by the following features: 1) the monoclonal nature of
their T cell receptor gene utilization (i.e., expression of V g 3/V d 2, and no junctional diversity); 2) exclusive residence in the epidermis (cells
in other epithelial tissues express different TCRs); and 3) their strikingly dendritic
morphology in situ. Current studies are directed toward characterizing the
keratinocyte-derived regulatory cytokines (including IL-7) that support their survival and
growth, the adhesion molecules that facilitate their immigration to and residence within
epidermis, and mechanisms by which they exert cytotoxicity against infected and
transformed cells in skin.
Selected Publications:
Kaminski MJ, Cruz PD Jr., Bergstresser PR, Takashima A (1993) Killing of
skin-derived tumor cells by mouse dendritic epidermal T cells. Cancer Res
53:4014-4019
Matsue H, Bergstresser PR, Takashima A (1993) Keratinocyte-derived IL-7
serves as a growth factor for dendritic epidermal T cells. J Immunol 151:6012-6019
Xu S, Ariizumi K, Caceres-Dittmar G, Edelbaum D, Hashimoto K,
Bergstresser PR, Takashima A (1995) Successive generation of antigen-presenting, dendritic
cell lines from murine epidermis. J Immunol 154:2697-2705
Kitajima T, Ariizumi K, Bergstresser PR, Takashima A: A novel mechanism
of glucocorticoid-induced immune suppression (1996) The inhibition of T cell-mediated
terminal maturation of a murine dendritic cell line . J Clin Invest 98:142-147
Yokota K, Ariizumi K, Kitajima T, Bergstresser PR, Street NE, Takashima
A (1996) Cytokine-mediated communication between dendritic epidermal T cells and
Langerhans cells: In vitro studies using cell lines. J Immunol 157:1529-1537
Kitajima T, Ariizumi K, Bergstresser PR, Takashima A (1996) Ultraviolet
B radiation sensitizes an epidermal dendritic cell line (XS52) to undergo apoptosis upon
antigen presentation to T cells . J Immunol 157:3312-3316
Lenz P, Elbe A, Stingl G, Bergstresser PR (1996) MHC class I expression
on dendritic cells is sufficient to sensitize for transplantation immunity. J Invest
Dermatol 107:844-848
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted keyword count
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Database: Medline abstracts (1967 - Present)
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Sort by: Score
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Show: Top 100 hits
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Results computed on: 6/9/2006