FRISC: The Faculty Research Interests Science Comparator

Michael S. Brown, M.D.
Cell Regulation; Genetics and Development, Integrative
Biology
Michael S. Brown, M.D.
Professor of Molecular Genetics and Internal Medicine
Cell Regulation
Genetics and
Development
Integrative
Biology
Office: (214) 648-2179
FAX: (214) 648-8804
Email: mbrownmsb@aol.com

New This Month | New This Year | Abstract | Selected Publications | FRISC Statistics Results - FULL MEDLINE:

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.
Joseph L Goldstein ... Michael S Brown
Arch Biochem Biophys 2002 Jan; 397(2)139-48.
Score: 0.985
Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells.
V C Hannah ... M S Brown
J Biol Chem 2001 Feb; 276(6)4365-72.
Score: 0.937
Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism.
Hitoshi Shimano
Vitam Horm 2002 ; 65()167-94.
Score: 0.843
[Sterol regulatory element-binding proteins and lipid metabolism]
Tao Tang ... Yan Li
Sheng Li Ke Xue Jin Zhan 2005 Jan; 36(1)29-34.
Score: 0.836
Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes.
H Shimano
Prog Lipid Res 2001 Nov; 40(6)439-52.
Score: 0.802
Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway.
Y Hirano ... R Sato
J Biol Chem 2001 Sep; 276(39)36431-7.
Score: 0.793
Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.
J D Horton ... I Shimomura
Curr Opin Lipidol 1999 Apr; 10(2)143-50.
Score: 0.777
Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.
J Sakai ... J L Goldstein
J Biol Chem 1997 Aug; 272(32)20213-21.
Score: 0.775
SREBPs, membrane lipid biosynthesis, and fatty acids.
T Y Chang
J Clin Invest 1997 Oct; 100(8)1905-6.
Score: 0.775
Regulation of gene expression by SREBP and SCAP.
P A Edwards ... A Venkateswaran
Biochim Biophys Acta 2000 Dec; 1529(1-3)103-13.
Score: 0.754
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.
M S Brown ... J L Goldstein
Proc Natl Acad Sci U S A 1999 Sep; 96(20)11041-8.
Score: 0.744
Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis.
Ruth McPherson ... Andre Gauthier
Biochem Cell Biol 2004 Feb; 82(1)201-11.
Score: 0.739
Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins.
Adam B Castoreno ... Axel Nohturfft
Proc Natl Acad Sci U S A 2005 Sep; 102(37)13129-34.
Score: 0.722
Sterol and fatty acid regulatory pathways in a Giardia lamblia-derived promoter: evidence for SREBP as an ancient transcription factor.
Tilla S Worgall ... Richard J Deckelbaum
J Lipid Res 2004 May; 45(5)981-8.
Score: 0.704
The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport.
J Sakai ... R B Rawson
Curr Opin Lipidol 2001 Jun; 12(3)261-6.
Score: 0.695
Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake.
M S Brown ... J L Goldstein
Nutr Rev 1998 Feb; 56(2 Pt 2)S1-3; discussion S54-75.
Score: 0.693
Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins.
M M Magaña ... T F Osborne
J Lipid Res 1997 Aug; 38(8)1630-8.
Score: 0.675
Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins.
D P Thewke ... M Sinensky
J Biol Chem 1998 Aug; 273(33)21402-7.
Score: 0.672
Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis.
Y Sakakura ... K Inoue
Biochem Biophys Res Commun 2001 Aug; 286(1)176-83.
Score: 0.666
Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins.
Lutz-W Weber ... Andreas Stampfl
World J Gastroenterol 2004 Nov; 10(21)3081-7.
Score: 0.660
Molecular aspects in feedback regulation of gene expression by cholesterol in mammalian cells.
T F Osborne ... V J LaMorte
Methods 1998 Sep; 16(1)42-8.
Score: 0.660
Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1.
S Scheek ... J L Goldstein
Proc Natl Acad Sci U S A 1997 Oct; 94(21)11179-83.
Score: 0.652
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).
B S Korn ... M S Brown
J Clin Invest 1998 Dec; 102(12)2050-60.
Score: 0.643
Sterol regulatory element-binding proteins (SREBPs) as regulators of lipid metabolism: polyunsaturated fatty acids oppose cholesterol-mediated induction of SREBP-1 maturation.
Hyoun-Ju Kim ... James M Ntambi
Ann N Y Acad Sci 2002 Jun; 967()34-42.
Score: 0.638
Dietary polyunsaturated fatty acids and regulation of gene transcription.
Donald B Jump
Curr Opin Lipidol 2002 Apr; 13(2)155-64.
Score: 0.630
SREBP transcription factors: master regulators of lipid homeostasis.
Delphine Eberlé ... Fabienne Foufelle
Biochimie 2004 Nov; 86(11)839-48.
Score: 0.629
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
Jay D Horton ... Joseph L Goldstein
Proc Natl Acad Sci U S A 2003 Oct; 100(21)12027-32.
Score: 0.629
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.
Z Sheng ... J L Goldstein
Proc Natl Acad Sci U S A 1995 Feb; 92(4)935-8.
Score: 0.625
The SREBP pathway--insights from Insigs and insects.
Robert B Rawson
Nat Rev Mol Cell Biol 2003 Aug; 4(8)631-40.
Score: 0.625
Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis.
I R Harris ... K R Feingold
J Lipid Res 1998 Feb; 39(2)412-22.
Score: 0.625
The SREBP pathway in Drosophila: regulation by palmitate, not sterols.
Adam C Seegmiller ... Robert B Rawson
Dev Cell 2002 Feb; 2(2)229-38.
Score: 0.624
Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver.
I Shimomura ... J D Horton
J Biol Chem 1998 Dec; 273(52)35299-306.
Score: 0.624
Low-temperature effect on the sterol-dependent processing of SREBPs and transcription of related genes in HepG2 cells.
Ishaiahu Shechter ... Guimin Guan
J Lipid Res 2003 Aug; 44(8)1581-90.
Score: 0.617
Identification of mutations in the gene encoding sterol regulatory element binding protein (SREBP)-2 in hypercholesterolaemic subjects.
P Y Muller ... A R Miserez
J Med Genet 2002 Apr; 39(4)271-5.
Score: 0.613
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
M Matsuda ... I Shimomura
Genes Dev 2001 May; 15(10)1206-16.
Score: 0.613
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Daisuke Yabe ... Joseph L Goldstein
Proc Natl Acad Sci U S A 2002 Oct; 99(20)12753-8.
Score: 0.611
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis.
J D Horton
Biochem Soc Trans 2002 Nov; 30(Pt 6)1091-5.
Score: 0.611
Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway.
Yuko Hirano ... Ryuichiro Sato
J Biol Chem 2003 May; 278(19)16809-19.
Score: 0.610
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins.
J T Pai ... J L Goldstein
J Biol Chem 1998 Oct; 273(40)26138-48.
Score: 0.610
Membrane topology of human insig-1, a protein regulator of lipid synthesis.
Jamison D Feramisco ... Michael S Brown
J Biol Chem 2004 Feb; 279(9)8487-96.
Score: 0.607
Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.
R A DeBose-Boyd ... P J Espenshade
Cell 1999 Dec; 99(7)703-12.
Score: 0.605
Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway.
H Heemers ... J V Swinnen
Mol Endocrinol 2001 Oct; 15(10)1817-28.
Score: 0.603
Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.
A Nohturfft ... J L Goldstein
Proc Natl Acad Sci U S A 1998 Oct; 95(22)12848-53.
Score: 0.598
[Regulation of gene expression by cholesterol and macrophage scavenger receptor]
Y Kawabe ... T Kodama
Nippon Rinsho 1994 Dec; 52(12)3191-6.
Score: 0.598
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
H Shimano ... J L Goldstein
J Clin Invest 1996 Oct; 98(7)1575-84.
Score: 0.597
HLH106, a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph.
J M Rosenfeld ... T F Osborne
J Biol Chem 1998 Jun; 273(26)16112-21.
Score: 0.595
Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.
J M Lopez ... T E Osborne
Proc Natl Acad Sci U S A 1996 Feb; 93(3)1049-53.
Score: 0.592
[Mechanism of action of sterol regulatory element binding proteins (SREBPs) in cholesterol and fatty-acid biosynthesis]
Natalia Manzano León ... Armando R Tovar
Rev Invest Clin 2002 Mar-Apr; 54(2)145-53.
Score: 0.592
Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins.
Y A Moon ... J D Horton
J Biol Chem 2001 Nov; 276(48)45358-66.
Score: 0.591
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.
Thomas Porstmann ... Almut Schulze
Oncogene 2005 Sep; 24(43)6465-81.
Score: 0.591
Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs).
Robert B Rawson
Biochem Soc Symp 2003 ; (70)221-31.
Score: 0.589
Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways.
M K Bennett ... T F Osborne
J Biol Chem 1995 Oct; 270(43)25578-83.
Score: 0.589
A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter.
K A Dooley ... T F Osborne
J Biol Chem 1999 Feb; 274(9)5285-91.
Score: 0.588
Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y.
K A Dooley ... T F Osborne
J Biol Chem 1998 Jan; 273(3)1349-56.
Score: 0.587
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
Luke J Engelking ... Guosheng Liang
J Clin Invest 2004 Apr; 113(8)1168-75.
Score: 0.586
Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter.
M M Magaña ... T F Osborne
J Biol Chem 1996 Dec; 271(51)32689-94.
Score: 0.585
Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
X Hua ... J L Goldstein
J Biol Chem 1996 Apr; 271(17)10379-84.
Score: 0.582
Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor.
Noriyuki Inoue ... Nobuhiro Yamada
Mol Cell Biol 2005 Oct; 25(20)8938-47.
Score: 0.581
Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein.
T S Worgall ... R J Deckelbaum
J Biol Chem 1998 Oct; 273(40)25537-40.
Score: 0.574
Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.
F Jeffrey Field ... Satya N Mathur
Biochem J 2002 Dec; 368(Pt 3)855-64.
Score: 0.574
Cholesterol homeostasis: clipping out a slippery regulator.
T F Osborne
Curr Biol 1997 Mar; 7(3)R172-4.
Score: 0.573
Proteolytic activation of SREBPs during adipocyte differentiation.
J Inoue ... R Sato
Biochem Biophys Res Commun 2001 May; 283(5)1157-61.
Score: 0.566
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.
A Nohturfft ... J L Goldstein
Proc Natl Acad Sci U S A 1996 Nov; 93(24)13709-14.
Score: 0.566
Lipogenic enzymes fatty acid synthase and acetyl-coenzyme A carboxylase are coexpressed with sterol regulatory element binding protein and Ki-67 in fetal tissues.
R E Wilentz ... E S Pizer
Pediatr Dev Pathol 2000 Nov-Dec; 3(6)525-31.
Score: 0.560
Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis.
Hang Wang ... Daniel L Kilpatrick
Mol Cell Biol 2002 Dec; 22(24)8478-90.
Score: 0.558
Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.
R B Rawson ... M S Brown
J Biol Chem 1999 Oct; 274(40)28549-56.
Score: 0.558
[THE METABOLISM OF UNSATURATED FATTY ACIDS. I. ON THE BIOSYNTHESIS OF HIGHLY UNSATURATED FATTY ACIDS.]
W STOFFEL
Hoppe Seylers Z Physiol Chem 1963 ; 333()71-88.
Score: 0.557
The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter.
Y A Moon ... K S Kim
J Biol Chem 2000 Sep; 275(39)30280-6.
Score: 0.556
Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Navdar Sever ... Russell A Debose-Boyd
J Biol Chem 2004 Oct; 279(41)43136-47.
Score: 0.555
Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.
J Sakai ... M S Brown
J Biol Chem 1998 Mar; 273(10)5785-93.
Score: 0.554
Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.
A Nohturfft ... M S Brown
Proc Natl Acad Sci U S A 1999 Sep; 96(20)11235-40.
Score: 0.554
Sterol regulatory element binding proteins: relationship of adipose tissue gene expression with obesity in humans.
Hannes Oberkofler ... Wolfgang Patsch
Biochim Biophys Acta 2002 May; 1575(1-3)75-81.
Score: 0.554
Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms.
Neale D Ridgway ... Thomas A Lagace
Biochem J 2003 Jun; 372(Pt 3)811-9.
Score: 0.553
Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein.
M K Bennett ... T F Osborne
J Biol Chem 1999 May; 274(19)13025-32.
Score: 0.553
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
A Luong ... J L Goldstein
J Biol Chem 2000 Aug; 275(34)26458-66.
Score: 0.551
Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein.
J N Athanikar ... T F Osborne
Proc Natl Acad Sci U S A 1998 Apr; 95(9)4935-40.
Score: 0.549
Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells.
Eimear Mullen ... Neil F Shay
J Nutr 2004 Nov; 134(11)2942-7.
Score: 0.547
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
X Hua ... X Wang
Proc Natl Acad Sci U S A 1993 Dec; 90(24)11603-7.
Score: 0.546
The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells.
Y Kawabe ... T Kodama
Biochem Biophys Res Commun 1995 Mar; 208(1)405-11.
Score: 0.545
Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism.
Tilla S Worgall ... Richard J Deckelbaum
J Biol Chem 2002 Feb; 277(6)3878-85.
Score: 0.540
Fatty acids: links between genes involved in fatty acid and cholesterol metabolism.
T S Worgall ... R J Deckelbaum
Curr Opin Clin Nutr Metab Care 1999 Mar; 2(2)127-33.
Score: 0.539
Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.
E A Duncan ... J Sakai
J Biol Chem 1997 May; 272(19)12778-85.
Score: 0.537
The physiological role of sterol regulatory element-binding protein-2 in cultured human cells.
Y Kawabe ... T Kodama
Biochim Biophys Acta 1999 Jan; 1436(3)307-18.
Score: 0.535
Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins.
Anne Kasus-Jacobi ... Michael S Brown
J Biol Chem 2003 Aug; 278(34)32380-9.
Score: 0.534
Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution.
A Párraga ... S K Burley
Structure 1998 May; 6(5)661-72.
Score: 0.534
Squalene synthase: structure and regulation.
T R Tansey ... I Shechter
Prog Nucleic Acid Res Mol Biol 2001 ; 65()157-95.
Score: 0.533
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.
I Shimomura ... M S Brown
Proc Natl Acad Sci U S A 1997 Nov; 94(23)12354-9.
Score: 0.532
Regulation of phosphatidylcholine metabolism in Chinese hamster ovary cells by the sterol regulatory element-binding protein (SREBP)/SREBP cleavage-activating protein pathway.
T A Lagace ... N D Ridgway
J Biol Chem 2000 May; 275(19)14367-74.
Score: 0.529
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.
J D Horton ... H Shimano
Proc Natl Acad Sci U S A 1998 May; 95(11)5987-92.
Score: 0.528
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.
X Wang ... J L Goldstein
EMBO J 1996 Mar; 15(5)1012-20.
Score: 0.528
Characterization of two Chinese hamster ovary cell lines expressing the COOH-terminal domains of sterol regulatory element-binding protein (SREBP)-1.
Y Kawabe ... R Sato
Cell Struct Funct 1998 Aug; 23(4)187-92.
Score: 0.525
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells.
Ishaiahu Shechter ... Guimin Guan
J Lipid Res 2003 Nov; 44(11)2169-80.
Score: 0.524
Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver.
H Shimano
Trends Cardiovasc Med 2000 Oct; 10(7)275-8.
Score: 0.524
Regulation of fatty acid synthase expression by cholesterol in human cultured cells.
Y Kawabe ... T Kodama
Biochem Biophys Res Commun 1996 Feb; 219(2)515-20.
Score: 0.522
Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells.
S M Jackson ... P A Edwards
J Lipid Res 1996 Aug; 37(8)1712-21.
Score: 0.522
SREBPs: sterol-regulated transcription factors.
Peter J Espenshade
J Cell Sci 2006 Mar; 119(Pt 6)973-6.
Score: 0.522
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
Yi Gong ... Jin Ye
Cell Metab 2006 Jan; 3(1)15-24.
Score: 0.520
Fatty acid synthesis in mitochondria. Elongation of short-chain fatty acids and formation of unsaturated long-chain fatty acids.
E J Christ
Biochim Biophys Acta 1968 Jan; 152(1)50-62.
Score: 0.518
[Sterol regulatory element binding proteins (SREBPs)]
J Sakai
Nippon Naika Gakkai Zasshi 2001 Oct; 90(10)2023-32.
Score: 0.518
Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins.
J V Swinnen ... G Verhoeven
Proc Natl Acad Sci U S A 1997 Nov; 94(24)12975-80.
Score: 0.517
The biosynthesis of unsaturated fatty acids.
A T James
Biochem J 1972 Jun; 128(1)3P.
Score: 0.514
Regulation of squalene epoxidase activity by membrane fatty acid composition in yeast.
T M Buttke ... M R Lowe
Lipids 1988 Jan; 23(1)68-71.
Score: 0.514
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
Jay D Horton ... Michael S Brown
J Clin Invest 2002 May; 109(9)1125-31.
Score: 0.514
Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase.
M M Magaña ... T F Osborne
J Biol Chem 2000 Feb; 275(7)4726-33.
Score: 0.513
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.
X Wang ... J L Goldstein
Cell 1994 Apr; 77(1)53-62.
Score: 0.512
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
Luke J Engelking ... Michael S Brown
J Clin Invest 2005 Sep; 115(9)2489-98.
Score: 0.511
[Sterol regulatory element binding protein that controls cholesterol metabolism]
R Sato
Nippon Rinsho 1999 Dec; 57(12)2678-83.
Score: 0.511
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1.
Joon No Lee ... Jin Ye
J Biol Chem 2004 Oct; 279(43)45257-65.
Score: 0.511
[Passive absorption of unsaturated fatty acids by cells. Fatty acids transporting proteins in cell cytosol]
V N Titov
Klin Lab Diagn 2003 Aug; (8)3-10.
Score: 0.510
Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action.
T F Osborne
J Biol Chem 2000 Oct; 275(42)32379-82.
Score: 0.509
Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription.
R Sato ... M Maeda
J Biol Chem 1999 Aug; 274(35)24714-20.
Score: 0.507
Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
Peter C W Lee ... Russell A Debose-Boyd
J Biol Chem 2005 Jul; 280(26)25242-9.
Score: 0.502
The biosynthesis of unsaturated fatty acids by bacilli. II. Temperature-dependent biosynthesis of polyunsaturated fatty acids.
A J Fulco
J Biol Chem 1970 Jun; 245(11)2985-90.
Score: 0.501
Cholesterol regulates ABCD2 expression: implications for the therapy of X-linked adrenoleukodystrophy.
Isabelle Weinhofer ... Johannes Berger
Hum Mol Genet 2002 Oct; 11(22)2701-8.
Score: 0.501
Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.
J Ou ... M S Brown
Proc Natl Acad Sci U S A 2001 May; 98(11)6027-32.
Score: 0.500
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.
R B Rawson ... J L Goldstein
Mol Cell 1997 Dec; 1(1)47-57.
Score: 0.498
Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis.
Rui-Hai Zhou ... John Y-J Shyy
Circ Res 2004 Sep; 95(5)471-8.
Score: 0.497
Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer.
Aikaterini Zoumi ... Vickie J Lamorte
Mol Cell Biol 2005 Apr; 25(8)2946-56.
Score: 0.495
Effects of unsaturated fatty acids on the morphogenesis of an unsaturated fatty acid auxotroph of Escherichia coli.
Y Kuriki
J Bacteriol 1981 Sep; 147(3)1121-4.
Score: 0.495
Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins.
Tong Lin ... John Y-J Shyy
Circ Res 2003 Jun; 92(12)1296-304.
Score: 0.494
Effect of unsaturated fatty acids on the development of respiration and on protein synthesis in an unsaturated fatty acid mutant of Saccharomyces cerevisiae.
P A Gordon ... P R Stewart
J Bacteriol 1972 May; 110(2)511-5.
Score: 0.493
Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.
Daisuke Yabe ... Michael S Brown
Proc Natl Acad Sci U S A 2003 Mar; 100(6)3155-60.
Score: 0.492
Oxidation of unsaturated fatty acids.
Nutr Rev 1970 Jun; 28(6)165-7.
Score: 0.492
Unsaturated fatty acids.
L O Simpson
N Z Med J 1988 Apr; 101(843)180.
Score: 0.492
Unsaturated fatty acids.
J Birkbeck
N Z Med J 1988 Mar; 101(841)124-5.
Score: 0.492
Polyunsaturated fatty acid regulation of gene expression.
J M Ntambi ... H Bené
J Mol Neurosci 2001 Apr-Jun; 16(2-3)273-8; discussion 279-84.
Score: 0.491
Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.
Daisuke Yabe ... Robert B Rawson
Proc Natl Acad Sci U S A 2002 Dec; 99(26)16672-7.
Score: 0.490
Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.
R B Rawson ... J L Goldstein
J Biol Chem 1998 Oct; 273(43)28261-9.
Score: 0.490
[Metabolism of cholesterol and fatty acids in nephrotic syndrome and its regulation by sterol regulatory element binding proteins (SREBP's). Effect of soy protein consumption]
Armando Tovar ... Nimbe Torres
Gac Med Mex 2005 Sep-Oct; 141(5)407-15.
Score: 0.490
SREBPs suppress IRS-2-mediated insulin signalling in the liver.
Tomohiro Ide ... Nobuhiro Yamada
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