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FRISC: The Faculty Research Interests Science Comparator
Zhijian (James) Chen, Ph.D.
Assistant Professor of Molecular Biology
Genetics and
Development
Office: (214) 648-1145
FAX: (214) 648-1196
Building: NA, Room: 8.202
Email: jchen@hamon.swmed.edu
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Results - FULL MEDLINE:
TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
C Wang ... Z J Chen
Nature 2001 Jul; 412(6844)346-51.
Score: 0.974
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.
L Deng ... Z J Chen
Cell 2000 Oct; 103(2)351-61.
Score: 0.786
The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling.
M Karin ... M Delhase
Semin Immunol 2000 Feb; 12(1)85-98.
Score: 0.667
TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.
Chee-Kwee Ea ... Zhijian J Chen
Proc Natl Acad Sci U S A 2004 Oct; 101(43)15318-23.
Score: 0.650
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
J A DiDonato ... M Karin
Nature 1997 Aug; 388(6642)548-54.
Score: 0.631
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
M Delhase ... M Karin
Science 1999 Apr; 284(5412)309-13.
Score: 0.613
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
Hisaaki Shinohara ... Tomohiro Kurosaki
J Exp Med 2005 Nov; 202(10)1423-31.
Score: 0.610
NAK is an IkappaB kinase-activating kinase.
Y Tojima ... M Nakanishi
Nature 2000 Apr; 404(6779)778-82.
Score: 0.609
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
D M Rothwarf ... M Karin
Nature 1998 Sep; 395(6699)297-300.
Score: 0.608
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.
Satoshi Kishida ... Jun Ninomiya-Tsuji
Genes Cells 2005 May; 10(5)447-54.
Score: 0.607
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.
Chee-Kwee Ea ... Zhijian J Chen
Mol Cell 2006 Apr; 22(2)245-57.
Score: 0.604
Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.
De-Xue Fu ... Chou-Zen Giam
J Biol Chem 2003 Jan; 278(3)1487-93.
Score: 0.602
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.
Lijun Sun ... Zhijian J Chen
Mol Cell 2004 May; 14(3)289-301.
Score: 0.588
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.
Zhao-Hui Wu ... Shigeki Miyamoto
Science 2006 Feb; 311(5764)1141-6.
Score: 0.586
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
M Karin ... Y Ben-Neriah
Annu Rev Immunol 2000 ; 18()621-63.
Score: 0.578
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex.
M Karin
Oncogene 1999 Nov; 18(49)6867-74.
Score: 0.576
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
Alain Chariot ... Ulrich Siebenlist
J Biol Chem 2002 Oct; 277(40)37029-36.
Score: 0.574
The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus.
D M Rothwarf ... M Karin
Sci STKE 1999 Oct; 1999(5)RE1.
Score: 0.571
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
S Nemoto ... A Lin
Mol Cell Biol 1998 Dec; 18(12)7336-43.
Score: 0.566
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.
B S Miller ... E Zandi
J Biol Chem 2001 Sep; 276(39)36320-6.
Score: 0.559
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
F Mercurio ... A Rao
Science 1997 Oct; 278(5339)860-6.
Score: 0.558
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.
Z J Chen ... T Maniatis
Cell 1996 Mar; 84(6)853-62.
Score: 0.551
The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.
D Krappmann ... C Scheidereit
J Biol Chem 2000 Sep; 275(38)29779-87.
Score: 0.551
Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase.
S H Korn ... Y M Janssen-Heininger
J Biol Chem 2001 Sep; 276(38)35693-700.
Score: 0.547
[Human pathologies associated with NF-kappaB defects]
Gilles Courtois ... Alain Israël
J Soc Biol 2004 ; 198(2)93-6.
Score: 0.545
Measurement of IKK activity in primary rat T cells: rapid activation and inactivation.
René Kupfer ... Robert I Scheinman
J Immunol Methods 2002 Aug; 266(1-2)155-64.
Score: 0.544
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]
Chuan-Jin Wu ... Jonathan D Ashwell
Nat Cell Biol 2006 Apr; 8(4)398-406.
Score: 0.543
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.
Atsuhiro Kanayama ... Zhijian J Chen
Mol Cell 2004 Aug; 15(4)535-48.
Score: 0.538
IKK alpha on center stage.
J A DiDonato
Sci STKE 2001 Aug; 2001(97)PE1.
Score: 0.537
Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.
G Xiao ... S C Sun
J Biol Chem 2000 Nov; 275(44)34060-7.
Score: 0.535
Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.
E Spencer ... Z J Chen
Genes Dev 1999 Feb; 13(3)284-94.
Score: 0.535
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
Zhanguo Gao ... Jianping Ye
J Biol Chem 2002 Dec; 277(50)48115-21.
Score: 0.529
The essential role of MEKK3 in TNF-induced NF-kappaB activation.
J Yang ... B Su
Nat Immunol 2001 Jul; 2(7)620-4.
Score: 0.529
Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.
Jeanette L Ducut Sigala ... Inder M Verma
Science 2004 Jun; 304(5679)1963-7.
Score: 0.525
Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants.
C Le Page ... J Hiscott
Virology 2001 Aug; 286(2)422-33.
Score: 0.523
Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts.
B Baumgartner ... K Brand
Leukemia 2002 Oct; 16(10)2062-71.
Score: 0.522
The role of ubiquitination in Drosophila innate immunity.
Rui Zhou ... Tom Maniatis
J Biol Chem 2005 Oct; 280(40)34048-55.
Score: 0.519
Activation and regulation of the IkappaB kinase in human B cells by CD40 signaling.
Y Kosaka ... R J Noelle
Eur J Immunol 1999 Apr; 29(4)1353-62.
Score: 0.519
Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.
A Khoshnan ... A E Nel
J Immunol 1999 Nov; 163(10)5444-52.
Score: 0.518
Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.
Peter Storz ... Alex Toker
Mol Pharmacol 2004 Oct; 66(4)870-9.
Score: 0.517
Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma.
S C Sun ... L Good
AIDS Res Hum Retroviruses 2000 Nov; 16(16)1591-6.
Score: 0.517
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation.
Ki-Young Lee ... Sankar Ghosh
Science 2005 Apr; 308(5718)114-8.
Score: 0.515
Ubiquitin signalling in the NF-kappaB pathway.
Zhijian J Chen
Nat Cell Biol 2005 Aug; 7(8)758-65.
Score: 0.515
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
E Zandi ... M Karin
Cell 1997 Oct; 91(2)243-52.
Score: 0.514
Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway.
Ping Zhang ... Wen-Ming Chu
EMBO Rep 2005 Jun; 6(6)531-7.
Score: 0.512
BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.
Estefania Claudio ... Ulrich Siebenlist
Nat Immunol 2002 Oct; 3(10)958-65.
Score: 0.508
Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase.
K I Jeon ... D M Jue
J Immunol 2000 Jun; 164(11)5981-9.
Score: 0.508
Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation.
H Sakurai ... T Sugita
J Biol Chem 1999 Apr; 274(15)10641-8.
Score: 0.506
Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.
William Reiley ... Shao-Cong Sun
Mol Cell Biol 2005 May; 25(10)3886-95.
Score: 0.506
G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling.
Andrew M F Liu ... Yung H Wong
J Biol Chem 2004 Dec; 279(51)53196-204.
Score: 0.505
Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.
V Heissmeyer ... C Scheidereit
Mol Cell Biol 2001 Feb; 21(4)1024-35.
Score: 0.505
The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex.
X H Li ... R B Gaynor
J Biol Chem 1999 Nov; 274(48)34417-24.
Score: 0.504
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.
Junko Mizukami ... Naoki Sakurai
Mol Cell Biol 2002 Feb; 22(4)992-1000.
Score: 0.502
Persistent activation of NF-kappa B by the tax transforming protein involves chronic phosphorylation of IkappaB kinase subunits IKKbeta and IKKgamma.
R S Carter ... D W Ballard
J Biol Chem 2001 Jul; 276(27)24445-8.
Score: 0.500
TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.
Aurore Morlon ... Asma Smahi
Hum Mol Genet 2005 Dec; 14(23)3751-7.
Score: 0.500
Constitutive nuclear expression of the I kappa B kinase complex and its activation in human neutrophils.
Thornin Ear ... Patrick P McDonald
J Immunol 2005 Aug; 175(3)1834-42.
Score: 0.500
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.
H Sakurai ... W Toriumi
J Biol Chem 1999 Oct; 274(43)30353-6.
Score: 0.499
Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha.
J Li ... S Jakes
J Biol Chem 1998 Nov; 273(46)30736-41.
Score: 0.498
IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide.
Fan Yang ... Cun-Yu Wang
J Immunol 2003 Jun; 170(11)5630-5.
Score: 0.497
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha.
Eric D Tang ... Kun-Liang Guan
J Biol Chem 2003 Sep; 278(39)37297-305.
Score: 0.495
Novel IKK inhibitors: beta-carbolines.
Alfredo C Castro ... Julian Adams
Bioorg Med Chem Lett 2003 Jul; 13(14)2419-22.
Score: 0.495
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.
Z W Li ... M Karin
J Exp Med 1999 Jun; 189(11)1839-45.
Score: 0.493
IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein.
E W Harhaj ... S C Sun
J Biol Chem 1999 Aug; 274(33)22911-4.
Score: 0.492
CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.
A Leonardi ... U Siebenlist
Proc Natl Acad Sci U S A 2000 Sep; 97(19)10494-9.
Score: 0.492
Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement.
Enza Piccolella ... Loretta Tuosto
J Immunol 2003 Mar; 170(6)2895-903.
Score: 0.490
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.
Marcello Arsura ... Gail E Sonenshein
Oncogene 2003 Jan; 22(3)412-25.
Score: 0.488
PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.
M C Bonnet ... E F Meurs
Mol Cell Biol 2000 Jul; 20(13)4532-42.
Score: 0.488
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex.
Megumi Funakoshi-Tago ... Tadashi Kasahara
J Biochem (Tokyo) 2005 Feb; 137(2)189-97.
Score: 0.488
Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected].
Eric D Tang ... Kun-Liang Guan
J Biol Chem 2003 Oct; 278(40)38566-70.
Score: 0.488
Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism.
N H Purcell ... A Lin
Am J Physiol Gastrointest Liver Physiol 2001 Apr; 280(4)G669-77.
Score: 0.487
IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex.
F Mercurio ... A M Manning
Mol Cell Biol 1999 Feb; 19(2)1526-38.
Score: 0.487
An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation.
Tao Hai ... Allan R Brasier
J Virol 2006 May; 80(9)4227-41.
Score: 0.487
Inhibition of IkappaB kinase activity by sodium salicylate in vitro does not reflect its inhibitory mechanism in intact cells.
D Alpert ... J Vilcek
J Biol Chem 2000 Apr; 275(15)10925-9.
Score: 0.487
Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.
Megumi Masaki ... Toshisuke Kawasaki
Eur J Biochem 2003 Jan; 270(1)76-83.
Score: 0.487
A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways.
Daniel Krappmann ... Claus Scheidereit
EMBO Rep 2005 Apr; 6(4)321-6.
Score: 0.486
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90.
Guoqing Chen ... David V Goeddel
Mol Cell 2002 Feb; 9(2)401-10.
Score: 0.486
NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.
Wen-Hui Hu ... John R Bethea
J Biol Chem 2005 Aug; 280(32)29233-41.
Score: 0.485
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
Andrew Kovalenko ... Gilles Courtois
Nature 2003 Aug; 424(6950)801-5.
Score: 0.484
The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF.
A Devin ... Liu Zg
Mol Cell Biol 2001 Jun; 21(12)3986-94.
Score: 0.482
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.
Y Hu ... M Karin
Science 1999 Apr; 284(5412)316-20.
Score: 0.482
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation.
A Devin ... Z Liu
Immunity 2000 Apr; 12(4)419-29.
Score: 0.482
IkappaB kinase is an essential component of the Tpl2 signaling pathway.
Michael Waterfield ... Shao-Cong Sun
Mol Cell Biol 2004 Jul; 24(13)6040-8.
Score: 0.481
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.
K Kishimoto ... J Ninomiya-Tsuji
J Biol Chem 2000 Mar; 275(10)7359-64.
Score: 0.478
Carbachol activates IkappaB kinase in isolated canine gastric parietal cells.
A Todisco ... K Tacey
Biochem Biophys Res Commun 1999 Aug; 261(3)877-84.
Score: 0.478
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.
H Nakano ... K Okumura
Proc Natl Acad Sci U S A 1998 Mar; 95(7)3537-42.
Score: 0.477
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Andreas Panopoulos ... Ebrahim Zandi
J Biol Chem 2005 Jan; 280(4)2912-23.
Score: 0.477
Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
S Hatakeyama ... R A Good
Proc Natl Acad Sci U S A 1999 Mar; 96(7)3859-63.
Score: 0.477
Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops.
Hideaki Kamata ... Hajime Hirata
FEBS Lett 2002 May; 519(1-3)231-7.
Score: 0.476
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.
Arlene E Kray ... Brian E Wadzinski
J Biol Chem 2005 Oct; 280(43)35974-82.
Score: 0.474
Mu-opioid receptor-mediated phosphorylation of IkappaB kinase in human neuroblastoma SH-SY5Y cells.
Andrew M F Liu ... Yung H Wong
Neurosignals 2005 ; 14(3)136-42.
Score: 0.474
Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
Yasunari Takada ... Bharat B Aggarwal
J Immunol 2006 Mar; 176(5)3127-40.
Score: 0.473
Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90.
Jean-Francois Pittet ... William J Welch
J Immunol 2005 Jan; 174(1)384-94.
Score: 0.472
Detection and purification of a multiprotein kinase complex from mammalian cells. IKK signalsome.
F Mercurio ... A M Manning
Methods Mol Biol 2000 ; 99()109-25.
Score: 0.472
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
Jae-Hyuck Shim ... Sankar Ghosh
Genes Dev 2005 Nov; 19(22)2668-81.
Score: 0.470
Distinct IkappaB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells.
Hideyasu Miura ... Shoji Yamaoka
Exp Cell Res 2005 Aug; 308(1)29-40.
Score: 0.470
The heat-shock-induced suppression of the IkappaB/NF-kappaB cascade is due to inactivation of upstream regulators of IkappaBalpha through insolubilization.
Kyoung-Hee Lee ... Chul-Gyu Yoo
Exp Cell Res 2004 Sep; 299(1)49-56.
Score: 0.470
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.
G Takaesu ... K Matsumoto
Mol Cell Biol 2001 Apr; 21(7)2475-84.
Score: 0.470
Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein.
G Xiao ... S C Sun
Oncogene 2000 Oct; 19(45)5198-203.
Score: 0.467
NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase.
M Zamanian-Daryoush ... B R Williams
Mol Cell Biol 2000 Feb; 20(4)1278-90.
Score: 0.466
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
J L Poyet ... E S Alnemri
J Biol Chem 2000 Dec; 275(48)37966-77.
Score: 0.466
Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression.
Udit N Verma ... Richard B Gaynor
J Biol Chem 2004 Jan; 279(5)3509-15.
Score: 0.466
Inhibition of JNK activation through NF-kappaB target genes.
G Tang ... A Lin
Nature 2001 Nov; 414(6861)313-7.
Score: 0.465
Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation.
Kyu-Jin Park ... Youn Tae Kwak
J Biol Chem 2003 Sep; 278(37)35272-8.
Score: 0.465
Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes.
S A Trushin ... C V Paya
J Biol Chem 1999 Aug; 274(33)22923-31.
Score: 0.465
Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation.
Shashi Prajapati ... Richard B Gaynor
J Biol Chem 2002 Jul; 277(27)24331-9.
Score: 0.465
Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.
Pattama Singhirunnusorn ... Hiroaki Sakurai
J Biol Chem 2005 Feb; 280(8)7359-68.
Score: 0.465
In vivo and in vitro recruitment of an IkappaBalpha-ubiquitin ligase to IkappaBalpha phosphorylated by IKK, leading to ubiquitination.
H Suzuki ... K Tanaka
Biochem Biophys Res Commun 1999 Mar; 256(1)121-6.
Score: 0.463
The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation.
Daniel Brian Nichols ... Joanna L Shisler
J Virol 2006 Jan; 80(2)578-86.
Score: 0.463
Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases.
Chun Wu ... Sankar Ghosh
J Biol Chem 2003 Aug; 278(34)31980-7.
Score: 0.462
Role of Drosophila IKK gamma in a toll-independent antibacterial immune response.
S Rutschmann ... D Ferrandon
Nat Immunol 2000 Oct; 1(4)342-7.
Score: 0.460
Calmodulin-dependent kinase II mediates T cell receptor/CD3- and phorbol ester-induced activation of IkappaB kinase.
K Hughes ... T Grundström
J Biol Chem 2001 Sep; 276(38)36008-13.
Score: 0.460
T cell receptor-induced lipid raft recruitment of the I kappa B kinase complex is necessary and sufficient for NF-kappa B activation occurring in the cytosol.
Andrea Sebald ... M Lienhard Schmitz
Eur J Immunol 2005 Jan; 35(1)318-25.
Score: 0.459
PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation.
B C Chen ... W W Lin
Br J Pharmacol 2001 Nov; 134(5)1055-65.
Score: 0.459
IkappaB kinase activation is involved in regulation of paclitaxel-induced apoptosis in human tumor cell lines.
Yi Huang ... Weimin Fan
Mol Pharmacol 2002 Jan; 61(1)105-13.
Score: 0.459
Host and parasite-derived IKK activities direct distinct temporal phases of NF-kappaB activation and target gene expression following Toxoplasma gondii infection.
Robert E Molestina ... Anthony P Sinai
J Cell Sci 2005 Dec; 118(Pt 24)5785-96.
Score: 0.457
NEMO trimerizes through its coiled-coil C-terminal domain.
Fabrice Agou ... Michel Véron
J Biol Chem 2002 May; 277(20)17464-75.
Score: 0.457
Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.
Holger Buss ... Michael Kracht
J Biol Chem 2004 Dec; 279(53)55633-43.
Score: 0.457
The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop.
Fan Yang ... Cun-Yu Wang
J Immunol 2004 Feb; 172(4)2446-52.
Score: 0.455
TRAF2: a double-edged sword?
Zong-Ping Xia ... Zhijian J Chen
Sci STKE 2005 Feb; 2005(272)pe7.
Score: 0.455
SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.
P Strack ... M Rolfe
Oncogene 2000 Jul; 19(31)3529-36.
Score: 0.454
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.
S P Hehner ... M L Schmitz
J Immunol 1999 Nov; 163(10)5617-23.
Score: 0.453
TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.
Marzenna Blonska ... Xin Lin
J Biol Chem 2005 Dec; 280(52)43056-63.
Score: 0.453
Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.
T Ishii ... A E Koromilas
Oncogene 2001 Apr; 20(15)1900-12.
Score: 0.453
Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IkappaB kinase and ribosomal kinase.
Liping Zhang ... Jie Du
Circ Res 2005 Nov; 97(10)975-82.
Score: 0.451
Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.
Meike Broemer ... Claus Scheidereit
Oncogene 2004 Jul; 23(31)5378-86.
Score: 0.451
IKK mediates ischemia-induced neuronal death.
Oliver Herrmann ... Markus Schwaninger
Nat Med 2005 Dec; 11(12)1322-9.
Score: 0.450
Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.
Sebastian Tegethoff ... Claus Scheidereit
Mol Cell Biol 2003 Mar; 23(6)2029-41.
Score: 0.449
Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.
A Salmerón ... S C Ley
J Biol Chem 2001 Jun; 276(25)22215-22.
Score: 0.447
IKK beta is required for Bcl-2-mediated NF-kappa B activation in ventricular myocytes.
Kelly M Regula ... Lorrie A Kirshenbaum
J Biol Chem 2002 Oct; 277(41)38676-82.
Score: 0.447
Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.
Shashi Prajapati ... Richard B Gaynor
J Biol Chem 2004 Jan; 279(3)1739-46.
Score: 0.442
The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-kappaB activation.
J Gil ... M Esteban
Oncogene 2001 Jan; 20(3)385-94.
Score: 0.442
IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal.
C Ji ... L J Marnett
J Biol Chem 2001 May; 276(21)18223-8.
Score: 0.441
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
Ray-Chang Wu ... Bert W O'Malley
Mol Cell Biol 2002 May; 22(10)3549-61.
Score: 0.441
The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase.
Y Lin ... Z G Liu
Mol Cell Biol 2000 Sep; 20(18)6638-45.
Score: 0.441
3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.
Hiroshi Tanaka ... Takashi Tsuruo
J Biol Chem 2005 Dec; 280(49)40965-73.
Score: 0.440
Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein.
E W Harhaj ... S C Sun
Oncogene 2000 Mar; 19(11)1448-56.
Score: 0.438
The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation.
M Karin
J Biol Chem 1999 Sep; 274(39)27339-42.
Score: 0.438
Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.
S Van Huffel ... R Beyaert
J Biol Chem 2001 Aug; 276(32)30216-23.
Score: 0.437
Role of IkappaB kinase in tumorigenesis.
Mickey C-T Hu ... M C Hung
Future Oncol 2005 Feb; 1(1)67-78.
Score: 0.437
CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response.
Tomohisa Kato ... Michael Karin
Mol Cell 2003 Oct; 12(4)829-39.
Score: 0.435
IKAP is a scaffold protein of the IkappaB kinase complex.
L Cohen ... P A Baeuerle
Nature 1998 Sep; 395(6699)292-6.
Score: 0.434
Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.
H Sakurai ... T Sugita
FEBS Lett 2000 Jun; 474(2-3)141-5.
Score: 0.433
The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors.
Tony T Huang ... Shigeki Miyamoto
Mol Cell Biol 2002 Aug; 22(16)5813-25.
Score: 0.431
Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester.
Akihiro Muto ... Naohiro Inohara
J Biol Chem 2002 Aug; 277(35)31871-6.
Score: 0.431
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
Sergey A Trushin ... Carlos V Paya
Mol Cell Biol 2003 Oct; 23(19)7068-81.
Score: 0.431
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.
Dora C Dias ... Zhen-Qiang Pan
Proc Natl Acad Sci U S A 2002 Dec; 99(26)16601-6.
Score: 0.431
Stimulus specificity of gene expression programs determined by temporal control of IKK activity.
Shannon L Werner ... Alexander Hoffmann
Science 2005 Sep; 309(5742)1857-61.
Score: 0.430
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
Zhanguo Gao ... Jianping Ye
Mol Endocrinol 2004 Aug; 18(8)2024-34.
Score: 0.429
Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress.
Tony T Huang ... Shigeki Miyamoto
Cell 2003 Nov; 115(5)565-76.
Score: 0.428
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta.
Z L Chu ... D W Ballard
J Biol Chem 1998 Jun; 273(26)15891-4.
Score: 0.427
IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.
Y Qian ... X Li
J Biol Chem 2001 Nov; 276(45)41661-7.
Score: 0.427
Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB.
V S Spiegelman ... S Y Fuchs
J Biol Chem 2001 Jul; 276(29)27152-8.
Score: 0.426
Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells.
A C Vertegaal ... A Zantema
Cell Signal 2000 Dec; 12(11-12)759-68.
Score: 0.425
Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.
Isabelle Lamsoul ... Françoise Bex
Mol Cell Biol 2005 Dec; 25(23)10391-406.
Score: 0.425
Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle.
Richard C Ho ... Laurie J Goodyear
Am J Physiol Cell Physiol 2005 Oct; 289(4)C794-801.
Score: 0.425
KSHV vFLIP binds to IKK-gamma to activate IKK.
Nigel Field ... Mary Collins
J Cell Sci 2003 Sep; 116(Pt 18)3721-8.
Score: 0.424
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
Valerie Lang ... Steven C Ley
Mol Cell Biol 2003 Jan; 23(1)402-13.
Score: 0.423
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
Philippe Soubeyran ... Ivan Dikic
Biochem J 2003 Feb; 370(Pt 1)29-34.
Score: 0.423
A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha.
L Vuillard ... R T Hay
FEBS Lett 1999 Jul; 455(3)311-4.
Score: 0.422
The IKK complex: an integrator of all signals that activate NF-kappaB?
A Israël
Trends Cell Biol 2000 Apr; 10(4)129-33.
Score: 0.422
IkappaB kinase signaling is essential for maintenance of mature B cells.
Manolis Pasparakis ... Klaus Rajewsky
J Exp Med 2002 Sep; 196(6)743-52.
Score: 0.420
Pheromone-dependent ubiquitination of the mitogen-activated protein kinase kinase Ste7.
Yuqi Wang ... Henrik G Dohlman
J Biol Chem 2002 May; 277(18)15766-72.
Score: 0.420
The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.
Thomas H Lee ... Michelle A Kelliher
J Biol Chem 2004 Aug; 279(32)33185-91.
Score: 0.420
The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis.
Simon Dai ... Yousef Abu-Amer
J Biol Chem 2004 Sep; 279(36)37219-22.
Score: 0.419
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.
Eugene Varfolomeev ... Avi Ashkenazi
J Biol Chem 2005 Dec; 280(49)40599-608.
Score: 0.419
The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6.
F Yang ... G W Varilek
Mol Pharmacol 2001 Sep; 60(3)528-33.
Score: 0.419
Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions.
Steffen E Meiler ... Anthony Rosenzweig
J Mol Cell Cardiol 2002 Mar; 34(3)349-59.
Score: 0.418
alpha3beta1 integrin induced suppression of the Caco-2 epithelial cell IL-1 signaling pathway leading to NF-(kappa)B activation.
Gongchu Li ... Dennis W McGee
Cell Immunol 2004 Sep-Oct; 231(1-2)30-9.
Score: 0.418
A new twist on trefoils. Focus on "TFF3 modulates NF-{kappa}B and a novel regulatory molecule of NF-{kappa}B in intestinal epithelial cells via a mechanism distinct from TNF-{alpha}".
Kim E Barrett
Am J Physiol Cell Physiol 2005 Nov; 289(5)C1069-71.
Score: 0.418
Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.
A Ciechanover ... A Orian
Biochimie 2001 Mar-Apr; 83(3-4)341-9.
Score: 0.418
Multiple signaling pathways leading to the activation of interferon regulatory factor 3.
Marc J Servant ... John Hiscott
Biochem Pharmacol 2002 Sep; 64(5-6)985-92.
Score: 0.416
Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti.
C Makris ... M Karin
Mol Cell 2000 Jun; 5(6)969-79.
Score: 0.416
Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
Yasunari Takada ... Bharat B Aggarwal
J Biol Chem 2005 Apr; 280(17)17203-12.
Score: 0.416
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
Hideki Sanjo ... Shizuo Akira
Mol Cell Biol 2003 Feb; 23(4)1231-8.
Score: 0.414
Signal-dependent and -independent degradation of free and NF-kappa B-bound IkappaBalpha.
M P Pando ... I M Verma
J Biol Chem 2000 Jul; 275(28)21278-86.
Score: 0.414
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.
A Yaron ... Y Ben-Neriah
Nature 1998 Dec; 396(6711)590-4.
Score: 0.414
All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex.
R Heilker ... J Eder
Eur J Biochem 1999 Jan; 259(1-2)253-61.
Score: 0.414
Regulatory functions of ubiquitination in the immune system.
Yinon Ben-Neriah
Nat Immunol 2002 Jan; 3(1)20-6.
Score: 0.414
Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.
Ali Khoshnan ... Paul H Patterson
J Neurosci 2004 Sep; 24(37)7999-8008.
Score: 0.413
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.
M J Yin ... R B Gaynor
Nature 1998 Nov; 396(6706)77-80.
Score: 0.413
Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src.
Andrew M F Liu ... Yung H Wong
J Biol Chem 2005 Oct; 280(41)34617-25.
Score: 0.413
IKKgamma /NEMO facilitates the recruitment of the IkappaB proteins into the IkappaB kinase complex.
Y Yamamoto ... R B Gaynor
J Biol Chem 2001 Sep; 276(39)36327-36.
Score: 0.413
Signaling by the Mpl receptor involves IKK and NF-kappaB.
Ying Zhang ... Katya Ravid
J Cell Biochem 2002 ; 85(3)523-35.
Score: 0.413
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
C Jobin ... R B Sartor
J Immunol 1999 Sep; 163(6)3474-83.
Score: 0.413
Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex.
X H Li ... R B Gaynor
J Biol Chem 2001 Feb; 276(6)4494-500.
Score: 0.412
Different modes of NF-kappaB/Rel activation in pancreatic lobules.
Hana Algül ... Roland M Schmid
Am J Physiol Gastrointest Liver Physiol 2002 Aug; 283(2)G270-81.
Score: 0.412
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
D Rudolph ... T W Mak
Genes Dev 2000 Apr; 14(7)854-62.
Score: 0.412
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Emilie Vinolo ... Fabrice Agou
J Biol Chem 2006 Mar; 281(10)6334-48.
Score: 0.412
CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation.
X Hong ... H Shu
FEBS Lett 2001 Jun; 499(1-2)133-6.
Score: 0.411
Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo.
M Roff ... R T Hay
J Biol Chem 1996 Mar; 271(13)7844-50.
Score: 0.410
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway.
Peter Storz ... Alex Toker
EMBO J 2003 Jan; 22(1)109-20.
Score: 0.410
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
Shao-Cong Sun ... Shoji Yamaoka
Oncogene 2005 Sep; 24(39)5952-64.
Score: 0.410
Hijacking of host cell IKK signalosomes by the transforming parasite Theileria.
Volker T Heussler ... Dirk A E Dobbelaere
Science 2002 Nov; 298(5595)1033-6.
Score: 0.409
Targeting I kappa B kinase for the treatment of inflammatory and other disorders.
James R Burke
Curr Opin Drug Discov Devel 2003 Sep; 6(5)720-8.
Score: 0.409
Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B.
Sandeep Sinha ... Robert M O'Doherty
J Biol Chem 2004 Oct; 279(40)41294-301.
Score: 0.409
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.
Zhengfan Jiang ... Xiaoxia Li
Mol Cell Biol 2002 Oct; 22(20)7158-67.
Score: 0.409
Angiotensin II induces nuclear factor- kappa B activation in cultured neonatal rat cardiomyocytes through protein kinase C signaling pathway.
P Rouet-Benzineb ... C Lafuma
J Mol Cell Cardiol 2000 Oct; 32(10)1767-78.
Score: 0.408
Structural basis for the interaction of TAK1 kinase with its activating protein TAB1.
Kieron Brown ... Graham M T Cheetham
J Mol Biol 2005 Dec; 354(5)1013-20.
Score: 0.408
Cholecystokinin activates a variety of intracellular signal transduction mechanisms in rodent pancreatic acinar cells.
John A Williams ... Andrzej Dabrowski
Pharmacol Toxicol 2002 Dec; 91(6)297-303.
Score: 0.408
SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis.
A R Willems ... M Tyers
Philos Trans R Soc Lond B Biol Sci 1999 Sep; 354(1389)1533-50.
Score: 0.407
[NF-kappaB tumorigenesis and drug developement]
Wei-Feng Liu ... Yue-Zhong Li
Sheng Wu Gong Cheng Xue Bao 2005 Jan; 21(1)12-8.
Score: 0.407
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.
M J May ... S Ghosh
Science 2000 Sep; 289(5484)1550-4.
Score: 0.407
IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.
Robert F Schwabe ... Hiroaki Sakurai
FASEB J 2005 Oct; 19(12)1758-60.
Score: 0.407
The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.
Yungfeng Feng ... Gregory D Longmore
Mol Cell Biol 2005 May; 25(10)4010-22.
Score: 0.406
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.
S Beinke ... S C Ley
Mol Cell Biol 2004 Nov; 24(21)9658-67.
Score: 0.405
Characterization of the Ikappa B-kinase NEMO binding domain.
Michael J May ... Sankar Ghosh
J Biol Chem 2002 Nov; 277(48)45992-6000.
Score: 0.405
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway.
F S Lee ... T Maniatis
Cell 1997 Jan; 88(2)213-22.
Score: 0.405
In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase.
Robert S Carter ... Dean W Ballard
J Biol Chem 2003 May; 278(22)19642-8.
Score: 0.405
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
Noriyuki Uemura ... Jun Ninomiya-Tsuji
J Biol Chem 2006 Mar; 281(12)7863-72.
Score: 0.404
Atypical mechanism of NF-kappaB activation during reoxygenation stress in microvascular endothelium: a role for tyrosine kinases.
Ramesh Natarajan ... Alpha A Fowler
Free Radic Biol Med 2002 Oct; 33(7)962.
Score: 0.404
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
Hiroaki Sakurai ... Ikuo Saiki
J Biol Chem 2003 Sep; 278(38)36916-23.
Score: 0.404
Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.
S P Hehner ... M L Schmitz
Mol Cell Biol 2000 Apr; 20(7)2556-68.
Score: 0.404
Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation.
Jason A Gustin ... David B Donner
J Biol Chem 2004 Jan; 279(3)1615-20.
Score: 0.404
NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes.
K R Aupperle ... G S Firestein
J Immunol 1999 Jul; 163(1)427-33.
Score: 0.403
Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions.
A O'Mahony ... W C Greene
Mol Cell Biol 2000 Feb; 20(4)1170-8.
Score: 0.403
Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways.
M S Cammarano ... A Minden
J Biol Chem 2001 Jul; 276(28)25876-82.
Score: 0.403
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.
E E Patton ... M Tyers
Genes Dev 1998 Mar; 12(5)692-705.
Score: 0.402
TAB3, a new binding partner of the protein kinase TAK1.
Peter C F Cheung ... Philip Cohen
Biochem J 2004 Feb; 378(Pt 1)27-34.
Score: 0.402
Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity.
Q K Huynh ... C S Tripp
J Biol Chem 2000 Aug; 275(34)25883-91.
Score: 0.401
Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation.
Christian Schmidt ... Paul J Chiao
Mol Cell 2003 Nov; 12(5)1287-300.
Score: 0.401
Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex.
Yuqi Wang ... Henrik G Dohlman
J Biol Chem 2003 Jun; 278(25)22284-9.
Score: 0.401
Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization.
K Wu ... Z Q Pan
J Biol Chem 2000 Oct; 275(41)32317-24.
Score: 0.400
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha.
P Tan ... Z Q Pan
Mol Cell 1999 Apr; 3(4)527-33.
Score: 0.400
Oyster IKK-like protein shares structural and functional properties with its mammalian homologues.
J M Escoubas ... P Roch
FEBS Lett 1999 Jun; 453(3)293-8.
Score: 0.399
Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding.
A J Schottelius ... A S Baldwin
J Biol Chem 1999 Nov; 274(45)31868-74.
Score: 0.399
Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication.
Soizic Bourteele ... Oliver Planz
J Virol 2005 May; 79(10)6043-51.
Score: 0.398
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.
S C Sun ... D W Ballard
Oncogene 1999 Nov; 18(49)6948-58.
Score: 0.398
E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities.
R Shao ... M C Hung
J Biol Chem 1999 Jul; 274(31)21495-8.
Score: 0.398
Transient platelet interaction induces MCP-1 production by endothelial cells via I kappa B kinase complex activation.
Meinrad Gawaz ... Korbinian Brand
Thromb Haemost 2002 Aug; 88(2)307-14.
Score: 0.398
F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
D Skowyra ... J W Harper
Cell 1997 Oct; 91(2)209-19.
Score: 0.397
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.
M Kitagawa ... K Nakayama
EMBO J 1999 May; 18(9)2401-10.
Score: 0.397
The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation.
Gang Min Hur ... Zheng-gang Liu
Genes Dev 2003 Apr; 17(7)873-82.
Score: 0.396
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.
Fumitaka Fujita ... Makoto Nakanishi
Mol Cell Biol 2003 Nov; 23(21)7780-93.
Score: 0.395
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.
P Kapahi ... M Karin
J Biol Chem 2000 Nov; 275(46)36062-6.
Score: 0.394
Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).
Chong-Shan Shi ... John H Kehrl
J Biol Chem 2003 Apr; 278(17)15429-34.
Score: 0.394
Mechanisms and regulation of the degradation of cyclin B.
A Hershko
Philos Trans R Soc Lond B Biol Sci 1999 Sep; 354(1389)1571-5; discussion 1575-6.
Score: 0.394
The signal transduction pathway of CD23 (Fc epsilon RIIb) targets I kappa B kinase.
R M Ten ... C V Paya
J Immunol 1999 Oct; 163(7)3851-7.
Score: 0.393
The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex.
Li Liu ... Preet M Chaudhary
J Biol Chem 2002 Apr; 277(16)13745-51.
Score: 0.392
NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cells.
Maria Pia Russo ... Christian Jobin
Cell Signal 2004 Jun; 16(6)741-50.
Score: 0.392
The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro.
L Ghoda ... W C Greene
J Biol Chem 1997 Aug; 272(34)21281-8.
Score: 0.392
[I kappa B kinase (IKK) complex]
T Fujita ... W Suhara
Tanpakushitsu Kakusan Koso 2000 Jun; 45(9 Suppl)1546-50.
Score: 0.392
Theileria-induced leukocyte transformation.
Dirk A E Dobbelaere ... Sven Rottenberg
Curr Opin Microbiol 2003 Aug; 6(4)377-82.
Score: 0.392
CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells.
R F Schwabe ... D A Brenner
J Immunol 2001 Jun; 166(11)6812-9.
Score: 0.391
Development and comparison of two nonradioactive kinase assays for I kappa B kinase.
Tammy M Sadler ... Yixian Zhang
Anal Biochem 2004 Mar; 326(1)106-13.
Score: 0.391
Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.
Nywana Sizemore ... George R Stark
Proc Natl Acad Sci U S A 2004 May; 101(21)7994-8.
Score: 0.391
Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules.
Taeil Kim ... Young-Joon Kim
Nat Immunol 2005 Feb; 6(2)211-8.
Score: 0.390
Identifica
