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FRISC: The Faculty Research Interests Science Comparator |
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Assistant Professor of Internal Medicine
Immunology
Office: (214) 648-2201
FAX: (214) 648-7995
Email: ldavi2@mednet.swmed.edu
The focus of our research is directed at
understanding human CD4+ T cell activation and cytokine production. Recent studies are
focused on dissecting the mechanisms involved in the development of T helper-1 (Th-1)
proinflammatory effector cells that secrete interferon-gamma and Th-2 effector cells that
secrete cytokines such as IL-4 that downregulate inflammatory responses. Another goal is
to identify T cell surface markers that correlate with each stage of post-thymic
differentiation. Information gained from these studies is applied to investigations of
chronic inflammatory diseases such as rheumatoid arthritis. These studies should lead to
the generation of more specific and effective treatments for autoimmune diseases.
Selected Publications:
Davis, L.S., H. Schulze-Koops, P.E.
Lipsky. (1999) Human CD4+ T cell differentiation and effector function: implications
for autoimmunity. Immuno. Res . 19:25-34
Lipsky, P.E. and L.S. Davis. (1998)
The central involvement of T cells in rheumatoid arthritis. The Immunologist
6:121-128
Davis, L.S. and P.E. Lipsky. (1998)
Disordered differentiation of memory T cells in rheumatoid arthritis. Rev. Rhum .
65:291-296
Schulze-Koops, H., P.E. Lipsky, and L.S.
Davis. (1998) Differentiation of human memory T cells into Th2-like effector cells is
dependent on IL-4 and CD28 stimulation and inhibited by T cell receptor ligation. Eur.
J. Immunol . 28:2517-2529
Schulze-Koops, H., L.S. Davis, T.P.
Haverty, M.C. Wacholtz, and P.E. Lipsky. (1998) Reduction of Th1 cell activity in the
peripheral circulation of patients with rheumatoid arthritis after treatment with a
non-depleting humanized monoclonal antibody to CD4. J. Rheumatol . 25:2065-2076
Schulze-Koops, H., L.S. Davis, A.F.
Kavanaugh, and P.E. Lipsky. (1997) Elevated cytokine messenger RNA levels in the
peripheral blood of patients with rheumatoid arthritis suggest different degrees of
myeloid cell activation. Arthritis Rheum . 40:639-647
Kavanaugh, A.F., L.S. Davis, R.I. Jain,
L.A. Nichols, S.H. Norris, and P.E. Lipsky. (1996) A phase I/II open label study of
the safety and efficacy of an anti-ICAM-1 (intercellular adhesion molecule-1; CD54)
monoclonal antibody in early rheumatoid arthritis. J. Rheumatol . 23:1338-1344
Davis, L.S., A.F. Kavanaugh, L.A. Nichols,
and P.E. Lipsky. (1995) Induction of persistent T cell hyporesponsiveness in vivo by
monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis . J. Immunol .
154:3525-3537
Thomas, R., L.S. Davis, and P.E. Lipsky.
(1994) Rheumatoid synovium is enriched in mature antigen- presenting dendritic
cells. J. Immunol . 152:2613-2623
Davis, L.S. and P.E. Lipsky. (1993)
Tolerance induction of human CD4+ T cells: Markedly enhanced sensitivity of memory versus
naive T cells to peripheral anergy. Cell. Immunol . 146:351-361
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Last updated: 17 Nov 2000
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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