FRISC: The Faculty Research Interests Science Comparator

Jef K. De Brabander, Ph.D.
Assistant Professor of Biochemistry
Biological Chemistry
Office: (214) 648-7808
FAX: (214) 648-6455
Email: jdebra@biochem.swmed.edu

New This Month | New This Year | Abstract | Selected Publications | FRISC Statistics Results - FULL MEDLINE:

Total synthesis and initial structure-function analysis of the potent V-ATPase inhibitors salicylihalamide A and related compounds.
Yusheng Wu ... Jef K De Brabander
J Am Chem Soc 2002 Apr; 124(13)3245-53.
Score: 0.716
The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C.
K A Hood ... J H Miller
Anticancer Drug Des 2001 Apr-Jun; 16(2-3)155-66.
Score: 0.577
Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity.
Kylie A Hood ... John H Miller
Cancer Res 2002 Jun; 62(12)3356-60.
Score: 0.573
Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp.
L M West ... C N Battershill
J Org Chem 2000 Jan; 65(2)445-9.
Score: 0.519
Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines.
Thomas N Gaitanos ... John H Miller
Cancer Res 2004 Aug; 64(15)5063-7.
Score: 0.506
Peloruside A enhances apoptosis in H-ras-transformed cells and is cytotoxic to proliferating T cells.
J H Miller ... P T Northcote
Apoptosis 2004 Nov; 9(6)785-96.
Score: 0.440
Novel marine and microbial natural product inhibitors of vacuolar ATPase.
John A Beutler ... Tawnya C McKee
Curr Med Chem 2003 May; 10(9)787-96.
Score: 0.439
Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties.
B Kunze ... H Reichenbach
J Antibiot (Tokyo) 1998 Dec; 51(12)1075-80.
Score: 0.438
Developments in marine natural products. Receptor-specific bioactive compounds.
T F Molinski
J Nat Prod 1993 Jan; 56(1)1-8.
Score: 0.411
Novel antitumor agents: marine sponge alkaloids, their synthetic analogs and derivatives.
Valery M Dembitsky ... Vladimir V Poroikov
Mini Rev Med Chem 2005 Mar; 5(3)319-36.
Score: 0.404
Small-molecule natural products: new structures, new activities.
Dwight D Baker ... Khisal A Alvi
Curr Opin Biotechnol 2004 Dec; 15(6)576-83.
Score: 0.399
Toward the total synthesis of natural peloruside a: stereoselective synthesis of the backbone of the core.
Bo Liu ... Wei-Shan Zhou
Org Lett 2004 Jan; 6(1)71-4.
Score: 0.396
Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A.
Xibin Liao ... Jef K De Brabander
Angew Chem Int Ed Engl 2003 Apr; 42(14)1648-52.
Score: 0.394
Actin-binding marine macrolides: total synthesis and biological importance.
Kap-Sun Yeung ... Ian Paterson
Angew Chem Int Ed Engl 2002 Dec; 41(24)4632-53.
Score: 0.393
Cytotoxic anticancer candidates from natural resources.
Jinwoong Kim ... Eun Jung Park
Curr Med Chem Anticancer Agents 2002 Jul; 2(4)485-537.
Score: 0.392
Drugs from the deep: marine natural products as drug candidates.
Burkhard Haefner
Drug Discov Today 2003 Jun; 8(12)536-44.
Score: 0.388
Toward a total synthesis of peloruside A: enantioselective preparation of the C8-C19 region.
Richard E Taylor ... Meizhong Jin
Org Lett 2003 Dec; 5(26)4959-61.
Score: 0.387
Development of new synthetic methods and its application to total synthesis of nitrogen-containing bioactive natural products.
Chihiro Kibayashi
Chem Pharm Bull (Tokyo) 2005 Nov; 53(11)1375-86.
Score: 0.387
Natural products from marine organisms and their associated microbes.
Gabriele M König ... Daniela Müller
Chembiochem 2006 Feb; 7(2)229-38.
Score: 0.386
Chemistry and biology of salicylihalamide a and related compounds.
Larry Yet
Chem Rev 2003 Nov; 103(11)4283-306.
Score: 0.385
Marine natural products as a source of novel pharmacological agents.
B K Carté
Curr Opin Biotechnol 1993 Jun; 4(3)275-9.
Score: 0.381
Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery.
Christine E Salomon ... David H Sherman
Nat Prod Rep 2004 Feb; 21(1)105-21.
Score: 0.375
[Anti-tumor natural products isolated from marine organisms]
I Kitagawa ... M Kobayashi
Gan To Kagaku Ryoho 1989 Jan; 16(1)1-8.
Score: 0.370
Marine actinomycete diversity and natural product discovery.
Paul R Jensen ... William Fenical
Antonie Van Leeuwenhoek 2005 Jan; 87(1)43-8.
Score: 0.369
Enhancing marine natural product structural diversity and bioactivity through semisynthesis and biocatalysis.
Mark T Hamann
Curr Pharm Des 2003 ; 9(11)879-89.
Score: 0.367
Toward the synthesis of peloruside a: fragment synthesis and coupling studies.
Ian Paterson ... Toralf Kühn
Org Lett 2003 Feb; 5(4)599-602.
Score: 0.358
A new isoquinoline alkaloid from the marine sponge Haliclona species.
M A Rashid ... M R Boyd
J Nat Prod 2001 Sep; 64(9)1249-50.
Score: 0.358
Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases.
M R Boyd ... E J Bowman
J Pharmacol Exp Ther 2001 Apr; 297(1)114-20.
Score: 0.356
Total synthesis and biological evaluation of (-)apicularen A and analogues thereof.
K C Nicolaou ... Paraskevi Giannakakou
Chemistry 2003 Dec; 9(24)6177-91.
Score: 0.353
Strategies for the discovery of secondary metabolites from marine bacteria: ecological perspectives.
P R Jensen ... W Fenical
Annu Rev Microbiol 1994 ; 48()559-84.
Score: 0.351
Anticancer activity of synthetic analogues of the phorboxazoles.
F M Uckun ... C J Forsyth
Bioorg Med Chem Lett 2001 May; 11(9)1181-3.
Score: 0.350
Marine peptides and related compounds in clinical trial.
Diwan S Rawat ... Himanshu Atheaya
Anticancer Agents Med Chem 2006 Jan; 6(1)33-40.
Score: 0.346
Spatial and temporal variability of cytotoxic metabolites in populations of the New Zealand sponge Mycale hentscheli.
M Page ... M Kelly
J Chem Ecol 2005 May; 31(5)1161-74.
Score: 0.344
A new calyculin derivative from the sponge Theonella swinhoei is a novel and potent inhibitor of tumor cell proliferation.
K G Steube ... H G Drexler
Anticancer Res 1998 Jan-Feb; 18(1A)129-37.
Score: 0.344
Marine natural products.
John W Blunt ... Michèle R Prinsep
Nat Prod Rep 2004 Feb; 21(1)1-49.
Score: 0.343
Marine natural products.
John W Blunt ... Michele R Prinsep
Nat Prod Rep 2005 Feb; 22(1)15-61.
Score: 0.342
Natural products with anti-HIV activity from marine organisms.
Leto-A Tziveleka ... Vassilios Roussis
Curr Top Med Chem 2003 ; 3(13)1512-35.
Score: 0.340
Additional cytotoxic polyacetylenes from the marine sponge Petrosia species.
Y J Lim ... J H Jung
J Nat Prod 2001 Jan; 64(1)46-53.
Score: 0.338
[Development of novel synthetic organic reactions: synthesis of antitumor natural products and leading compounds for new pharmaceuticals]
Yasuyuki Kita
Yakugaku Zasshi 2002 Dec; 122(12)1011-35.
Score: 0.337
Marine natural products.
John W Blunt ... Michèle R Prinsep
Nat Prod Rep 2003 Feb; 20(1)1-48.
Score: 0.335
Synthesis and cytostatic properties of structure-simplified analogs of dolastatin 15.
M K Hu ... W S Huang
J Pept Res 1999 Dec; 54(6)460-7.
Score: 0.334
Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1.
Xiao-Song Xie ... Jef K De Brabander
J Biol Chem 2004 May; 279(19)19755-63.
Score: 0.333
Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge Discodermia species.
Gopal K Paul ... Shirley A Pomponi
J Nat Prod 2002 Jan; 65(1)59-61.
Score: 0.333
The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products.
Alison Butler ... Jayme N Carter-Franklin
Nat Prod Rep 2004 Feb; 21(1)180-8.
Score: 0.329
Highlights of marine natural products chemistry (1972-1999).
D J Faulkner
Nat Prod Rep 2000 Feb; 17(1)1-6.
Score: 0.328
Marine pharmacology in 1999: antitumor and cytotoxic compounds.
A M Mayer ... V K Lehmann
Anticancer Res 2001 Jul-Aug; 21(4A)2489-500.
Score: 0.327
A marine natural product database.
Jing Lei ... Jiaju Zhou
J Chem Inf Comput Sci 2002 May-Jun; 42(3)742-8.
Score: 0.326
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.
Kyoko Nakagawa-Goto ... Kuo-Hsiung Lee
Bioorg Med Chem Lett 2005 Jun; 15(12)3016-9.
Score: 0.325
Stereoselective synthesis of the C(1)-C(11) fragment of peloruside A.
Robert M Owen ... William R Roush
Org Lett 2005 Sep; 7(18)3941-4.
Score: 0.324
Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx.
S H Sennett ... A E Wright
J Nat Prod 1992 Oct; 55(10)1421-9.
Score: 0.324
Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products.
Daniel V Labarbera ... Edward B Skibo
Bioorg Med Chem 2005 Jan; 13(2)387-95.
Score: 0.322
Total synthesis and chemical biology of the sarcodictyins.
K C Nicolaou ... T Li
Chem Pharm Bull (Tokyo) 1999 Sep; 47(9)1199-213.
Score: 0.321
Natural products as probes of cell biology: 20 years of didemnin research.
Matthew D Vera ... Madeleine M Joullié
Med Res Rev 2002 Mar; 22(2)102-45.
Score: 0.321
Improved total synthesis and structure-activity relationship of arenastatin A, a potent cytotoxic spongean depsipeptide.
M Kobayashi ... I Kitagawa
Chem Pharm Bull (Tokyo) 1995 Sep; 43(9)1598-600.
Score: 0.320
HIV reverse transcriptase inhibitors of natural origin.
G Matthée ... G M König
Planta Med 1999 Aug; 65(6)493-506.
Score: 0.319
A clinical armamentarium of marine-derived anti-cancer compounds.
José M Jimeno
Anticancer Drugs 2002 May; 13 Suppl 1()S15-9.
Score: 0.317
Formal total synthesis of salicylihalamides A and B.
Georgina A Holloway ... Mark A Rizzacasa
J Org Chem 2003 Mar; 68(6)2200-4.
Score: 0.317
Challenges and rewards of research in marine natural products chemistry in Brazil.
Roberto G S Berlinck ... Paulo R R Minarini
J Nat Prod 2004 Mar; 67(3)510-22.
Score: 0.316
Mechanism targeted discovery of antitumor marine natural products.
Dale G Nagle ... Yong-Pil Kim
Curr Med Chem 2004 Jul; 11(13)1725-56.
Score: 0.315
Marine natural products as anticancer drugs.
T Luke Simmons ... William H Gerwick
Mol Cancer Ther 2005 Feb; 4(2)333-42.
Score: 0.315
Advances in marine natural products of the indole and annelated indole series: chemical and biological aspects.
U Pindur ... T Lemster
Curr Med Chem 2001 Nov; 8(13)1681-98.
Score: 0.315
Marine pharmacology in 2000: antitumor and cytotoxic compounds.
Alejandro M S Mayer ... Kirk R Gustafson
Int J Cancer 2003 Jun; 105(3)291-9.
Score: 0.313
Secondary metabolites from marine organisms.
K L Rinehart
Ciba Found Symp 1992 ; 171()236-49; discussion 249-54.
Score: 0.313
Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles.
Jenny Chan ... Jerry Pelletier
RNA 2004 Mar; 10(3)528-43.
Score: 0.313
Chemistry of renieramycins. Part 4.synthesis of a simple natural marine product, 6-hydroxy-7-methoxyisoquinolinemethanol.
Naoki Saito ... Akinori Kubo
Chem Pharm Bull (Tokyo) 2004 Feb; 52(2)282-6.
Score: 0.312
Chemistry and biology of new marine alkaloids from the indole and annelated indole series.
Alparslan Aygün ... Ulf Pindur
Curr Med Chem 2003 Jul; 10(13)1113-27.
Score: 0.312
Marine natural products: synthetic aspects.
Gillian M Nicholas ... Andrew J Phillips
Nat Prod Rep 2005 Apr; 22(2)144-61.
Score: 0.311
Marine natural products research: current directions and future potential.
G M König ... A D Wright
Planta Med 1996 Jun; 62(3)193-211.
Score: 0.311
The discovery and development of marine compounds with pharmaceutical potential.
M H Munro ... A R Duckworth
J Biotechnol 1999 Apr; 70(1-3)15-25.
Score: 0.311
Compounds with anti-HIV activity from plants.
P J Houghton
Trans R Soc Trop Med Hyg 1996 Nov-Dec; 90(6)601-4.
Score: 0.311
The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula.
Lik Tong Tan ... William H Gerwick
J Nat Prod 2003 Jun; 66(6)764-71.
Score: 0.311
Biosynthetic engineering of natural products for lead optimization and development.
Barrie Wilkinson ... Steven J Moss
Curr Opin Drug Discov Devel 2005 Nov; 8(6)748-56.
Score: 0.305
Empirical antibacterial drug discovery--foundation in natural products.
Sheo B Singh ... John F Barrett
Biochem Pharmacol 2006 Mar; 71(7)1006-15.
Score: 0.305
Asymmetric total synthesis of complex marine natural products.
Jorma Hassfeld ... Mathias Christmann
Adv Biochem Eng Biotechnol 2005 ; 97()133-203.
Score: 0.305
Naturally occurring peroxides with biological activities.
Mankil Jung ... Moonsoo Park
Mini Rev Med Chem 2003 Mar; 3(2)159-65.
Score: 0.305
Marine natural products.
D J Faulkner
Nat Prod Rep 1991 Apr; 8(2)97-147.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 1990 Aug; 7(4)269-309.
Score: 0.304
Developmental therapeutics program at the NCI: molecular target and drug discovery process.
M Monga ... E A Sausville
Leukemia 2002 Apr; 16(4)520-6.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 1993 Oct; 10(5)497-539.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 1986 Feb; 3(1)1-33.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 2001 Feb; 18(1)1-49.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 1988 Dec; 5(6)613-63.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 1987 Oct; 4(5)539-76.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 1998 Apr; 15(2)113-58.
Score: 0.304
A rapid mechanism-based screen to detect potential anti-cancer agents.
D S Swaffar ... L R Barrows
Anticancer Drugs 1994 Feb; 5(1)15-23.
Score: 0.304
Three new cyclic peroxides from the marine sponge Plakortis aff simplex.
Amira Rudi ... Yoel Kashman
J Nat Prod 2003 May; 66(5)682-5.
Score: 0.304
Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases.
Waseem Gul ... Mark T Hamann
Life Sci 2005 Dec; 78(5)442-53.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 1996 Apr; 13(2)75-125.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 2000 Feb; 17(1)7-55.
Score: 0.304
Marine natural products.
D J Faulkner
Nat Prod Rep 1994 Aug; 11(4)355-94.
Score: 0.304
A profile of the in vitro antitumor activity of lissoclinolide.
Adam D Richardson ... Chris M Ireland
Toxicol Appl Pharmacol 2004 Feb; 195(1)55-61.
Score: 0.303
Marine natural products.
John W Blunt ... Michèle R Prinsep
Nat Prod Rep 2006 Feb; 23(1)26-78.
Score: 0.303
Bioactive natural products from marine invertebrates and associated fungi.
P Proksch ... K Steube
Prog Mol Subcell Biol 2003 ; 37()117-42.
Score: 0.302
Induction of apoptosis by apicularen A in human promyelocytic leukemia cell line HL-60.
Jangja Hong ... Kazuo Ohuchi
Planta Med 2005 Apr; 71(4)306-12.
Score: 0.302
FR901464: total synthesis, proof of structure, and evaluation of synthetic analogues.
C F Thompson ... E N Jacobsen
J Am Chem Soc 2001 Oct; 123(41)9974-83.
Score: 0.301
[Studies on discovery and synthesis of bioactive marine organic molecules]
Yasuji Yamada
Yakugaku Zasshi 2002 Oct; 122(10)727-43.
Score: 0.301
Will natural products remain an important source of drug research for the future?
L J Nisbet ... M Moore
Curr Opin Biotechnol 1997 Dec; 8(6)708-12.
Score: 0.301
Mycalamides C and D, cytotoxic compounds from the marine sponge Stylinos n. species.
J S Simpson ... J N Hooper
J Nat Prod 2000 May; 63(5)704-6.
Score: 0.301
Natural Products in Drug Discovery and Development. 27-28 June 2005, London, UK.
A Harvey
IDrugs 2005 Sep; 8(9)719-21.
Score: 0.301
Cytotoxic polyacetylenic alcohols from the marine sponge Petrosia species.
Y J Lim ... J H Jung
J Nat Prod 2001 Dec; 64(12)1565-7.
Score: 0.300
Marine natural products: synthetic aspects.
Gillian M Nicholas ... Andrew J Phillips
Nat Prod Rep 2006 Feb; 23(1)79-99.
Score: 0.300
(+)-discodermolide: a marine natural product against cancer.
Marcus Vinícius Nora De Souza
ScientificWorldJournal 2004 Jun; 4()415-36.
Score: 0.299
Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products.
J L Fortman ... David H Sherman
Chembiochem 2005 Jun; 6(6)960-78.
Score: 0.299
New pharmaceuticals from marine organisms.
W Fenical
Trends Biotechnol 1997 Sep; 15(9)339-41.
Score: 0.299
The discovery of marine natural products with therapeutic potential.
O J McConnell ... F E Koehn
Biotechnology 1994 ; 26()109-74.
Score: 0.298
Marine natural products and their potential applications as anti-infective agents.
Marwa Donia ... Mark T Hamann
Lancet Infect Dis 2003 Jun; 3(6)338-48.
Score: 0.298
Assignment of absolute stereochemistry and total synthesis of (-)-spongidepsin.
Arun K Ghosh ... Xiaoming Xu
Org Lett 2004 Jun; 6(12)2055-8.
Score: 0.298
Total synthesis of marine natural products driven by novel structure, potent biological activity, and/or synthetic methodology.
D Romo ... M M Cox
Ernst Schering Res Found Workshop 2000 ; (32)103-48.
Score: 0.297
Cytotoxic furanosesterterpenes from a marine sponge Psammocinia sp.
Kyutaek Choi ... Jee H Jung
J Nat Prod 2004 Jul; 67(7)1186-9.
Score: 0.297
Total synthesis of a stereoisomer of bistramide C and assignment of configuration of the natural product.
Peter Wipf ... Seiji Yoshimura
Chemistry 2002 Apr; 8(7)1670-81.
Score: 0.297
Diabetes and hypertension, the deadly duet: importance, therapeutic strategy, and selection of drug therapy.
Prakash C Deedwania
Cardiol Clin 2005 May; 23(2)139-52.
Score: 0.296
Psammaplysin C: a new cytotoxic dibromotyrosine-derived metabolite from the marine sponge Druinella (= Psammaplysilla) purpurea.
B R Copp ... L R Barrows
J Nat Prod 1992 Jun; 55(6)822-3.
Score: 0.296
Predictive statistics and artificial intelligence in the U.S. National Cancer Institute's Drug Discovery Program for Cancer and AIDS.
J N Weinstein ... A D Koutsoukos
Stem Cells 1994 Jan; 12(1)13-22.
Score: 0.295
Biological basis for cancer treatment.
B A Chabner
Ann Intern Med 1993 Apr; 118(8)633-7.
Score: 0.295
Marine pharmacology in 2001-2: antitumour and cytotoxic compounds.
Alejandro M S Mayer ... Kirk R Gustafson
Eur J Cancer 2004 Dec; 40(18)2676-704.
Score: 0.295
Highly efficient biomimetic total synthesis and structural verification of bistratamides E and J from Lissoclinum bistratum.
Shu-Li You ... Jeffery W Kelly
Chemistry 2004 Jan; 10(1)71-5.
Score: 0.295
[Development of marine-derived anti-cancer compounds]
Tetsuo Taguchi
Gan To Kagaku Ryoho 2003 May; 30(5)579-88.
Score: 0.295
Cytotoxic natural products from Formosan plants and marine organisms.
Shoei-Sheng Lee ... Wen-Liang Chang
Curr Med Chem 2004 Jun; 11(11)1461-77.
Score: 0.294
Some marine ecological phenomena: chemical basis and biomedical potential.
P J Scheuer
Science 1990 Apr; 248(4952)173-7.
Score: 0.294
Induction of apoptosis of RAW 264.7 cells by the cytostatic macrolide apicularen A.
JangJa Hong ... Kazuo Ohuchi
J Pharm Pharmacol 2003 Sep; 55(9)1299-306.
Score: 0.294
[Some results and prospects of studies in the area of marine biochemistry and biotechnology]
G B Eliakov ... V V Mikhaĭlov
Bioorg Khim 1992 Oct-Nov; 18(10-11)1424-40.
Score: 0.294
Chemical diversity of bioactive marine natural products: an illustrative case study.
Valeria Costantino ... Orazio Taglialatela-Scafati
Curr Med Chem 2004 Jul; 11(13)1671-92.
Score: 0.294
Molecular mechanism of herbs in human lung cancer cells.
Tanawan Kummalue
J Med Assoc Thai 2005 Nov; 88(11)1725-34.
Score: 0.293
New cytotoxic polyacetylenes from the marine sponge Petrosia.
Y J Lim ... D k Kim
J Nat Prod 1999 Sep; 62(9)1215-7.
Score: 0.292
New sesquiterpene hydroquinones from a Taiwanese marine sponge Polyfibrospongia australis.
Y C Shen ... P W Hsieh
J Nat Prod 1997 Feb; 60(2)93-7.
Score: 0.292
Mining the microbial metabolome: a new frontier for natural product lead discovery.
Natasa Perić-Concha ... Paul F Long
Drug Discov Today 2003 Dec; 8(23)1078-84.
Score: 0.292
Cytotoxic isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.
Mostafa Fouad ... Peter Proksch
J Nat Prod 2006 Feb; 69(2)211-8.
Score: 0.291
[Application of chemical ecology in controlling marine fouling organisms]
Fang Fang ... Qing Liu
Ying Yong Sheng Tai Xue Bao 2005 Oct; 16(10)1997-2002.
Score: 0.291
Integrated approach to explore the potential of marine microorganisms for the production of bioactive metabolites.
Irene Wagner-Döbler ... Hartmut Laatsch
Adv Biochem Eng Biotechnol 2002 ; 74()207-38.
Score: 0.291
Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase.
Gillian M Nicholas ... Carole A Bewley
Bioorg Med Chem Lett 2002 Sep; 12(17)2487-90.
Score: 0.291
Discovery of short, 3'-cholesterol-modified DNA duplexes with unique antitumor cell activity.
J H Zhou ... Y C Cheng
Cancer Res 1994 Nov; 54(22)5783-7.
Score: 0.290
Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1).
Dale G Nagle ... Yu-Dong Zhou
Curr Drug Targets 2006 Mar; 7(3)355-69.
Score: 0.289
New cytotoxic sesterterpenes from the sponge Sarcotragus species.
Y Liu ... J H Jung
J Nat Prod 2001 Oct; 64(10)1301-4.
Score: 0.289
Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic.
Jennifer A Leeds ... Philipp Krastel
Expert Opin Investig Drugs 2006 Mar; 15(3)211-26.
Score: 0.289
Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species.
L M West ... M J Page
J Nat Prod 2000 May; 63(5)707-9.
Score: 0.289
Biotic interactions of marine algae.
Philippe Potin ... Bernard Kloareg
Curr Opin Plant Biol 2002 Aug; 5(4)308-17.
Score: 0.289
Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis.
Francis Robert ... Jerry Pelletier
RNA 2006 May; 12(5)717-25.
Score: 0.289
[Recent progress of natural product chemistry and potential application in fertility control]
C Tamm
Shengzhi Yu Biyun 1983 Feb; 3(2)13-6.
Score: 0.288
Total synthesis and revision of stereochemistry of the marine metabolite trunkamide A.
P Wipf ... Y Uto
J Org Chem 2000 Feb; 65(4)1037-49.
Score: 0.288
Identification of structural components associated with cytostatic activity in MCF-7 but not in MDA-MB-231 cells.
Albert R Cunningham ... Billy W Day
Bioorg Med Chem 2003 Nov; 11(23)5249-58.
Score: 0.288
Synthesis, structure revision, and absolute configuration of (+)-didemniserinolipid B, a serinol marine natural product from a tunicate Didemnum sp.
Hiromasa Kiyota ... Steven V Ley
Org Lett 2002 Sep; 4(19)3223-6.
Score: 0.287
Aldose reductase inhibitors from natural sources.
Jesús Angel de la Fuente ... Sonia Manzanaro
Nat Prod Rep 2003 Apr; 20(2)243-51.
Score: 0.287
The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore.
Christopher S Stevenson ... Lisa A Marshall
J Pharmacol Exp Ther 2002 Nov; 303(2)858-66.
Score: 0.287
Synthesis and biological evaluation of caulibugulones A-E.
Peter Wipf ... John S Lazo
Org Biomol Chem 2004 Aug; 2(15)2173-4.
Score: 0.286
Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents.
D L Boger ... Q Jin
J Org Chem 2000 Apr; 65(8)2479-83.
Score: 0.286
Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinones from the marine bryozoan Caulibugula intermis.
Dennis J Milanowski ... James B McMahon
J Nat Prod 2004 Jan; 67(1)70-3.
Score: 0.286
[Bioactive compounds from marine sponges and cell culture of marine sponges]
Xiao-Ying Zhang ... Wei Zhang
Sheng Wu Gong Cheng Xue Bao 2002 Jan; 18(1)10-5.
Score: 0.286
D. John Faulkner (1942-2002): marine natural products chemistry and marine chemical ecology.
William Fenical
Angew Chem Int Ed Engl 2003 Apr; 42(13)1438-9.
Score: 0.286
Synthesis of the core structure of apicularen a by transannular cyclization.
Sven M Kühnert ... Martin E Maier
Org Lett 2002 Feb; 4(4)643-6.
Score: 0.285
The total synthesis of (-)-callystatin A.
Markus Kalesse ... Thomas Scheper
Chemistry 2003 Mar; 9(5)1129-36.
Score: 0.285
Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase.
K Nicolaou ... J Casida
Chem Biol 2000 Dec; 7(12)979-92.
Score: 0.284
Marine organisms: an alternative source of potentially valuable natural products.
A Kelecom
Mem Inst Oswaldo Cruz 1991 ; 86 Suppl 2()99-106.
Score: 0.284
Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp..
Naoya Oku ... Nobuhiro Fusetani
J Nat Prod 2003 Aug; 66(8)1136-9.
Score: 0.284
Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.
S C Kuo ... E Hamel
J Med Chem 1993 Apr; 36(9)1146-56.
Score: 0.284
Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development.
G M Cragg
Med Res Rev 1998 Sep; 18(5)315-31.
Score: 0.284
Structures and cytotoxic properties of sponge-derived bisannulated acridines.
Zia Thale ... Phillip Crews
J Org Chem 2002 Dec; 67(26)9384-91.
Score: 0.284
Five new discodermolide analogues from the marine sponge Discodermia species.
Sarath P Gunasekera ... Shirley A Pomponi
J Nat Prod 2002 Nov; 65(11)1643-8.
Score: 0.283
Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
K Chen ... K H Lee
J Med Chem 1997 Jul; 40(14)2266-75.
Score: 0.283
Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity.
Cailean Clarkson ... Peter Smith
Bioorg Med Chem 2003 Oct; 11(20)4417-22.
Score: 0.282
Antimycobacterial natural products.
Brent R Copp
Nat Prod Rep 2003 Dec; 20(6)535-57.
Score: 0.282
New methods for medicinal chemistry--universal gene cloning and expression systems for production of marine bioactive metabolites.
Walter C Dunlap ... Paul F Long
Curr Med Chem 2006 ; 13(6)697-710.
Score: 0.282
The impact of bacterial genomics on natural product research.
Helge B Bode ... Rolf Müller
Angew Chem Int Ed Engl 2005 Oct; 44(42)6828-46.
Score: 0.281
Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy.
David J Newman ... Edward A Sausville
Curr Cancer Drug Targets 2002 Dec; 2(4)279-308.
Score: 0.281
Discovery and evaluation of inhibitors of human sphingosine kinase.
Kevin J French ... Charles D Smith
Cancer Res 2003 Sep; 63(18)5962-9.
Score: 0.281
Synthetic studies toward bioactive cyclic peroxides from the marine sponge Plakortis angulospiculatus.
Gang Yao ... Kosta Steliou
Org Lett 2002 Feb; 4(4)485-8.
Score: 0.280
Haliclostanone sulfate and halistanol sulfate from an Indo-Pacific Haliclona sponge.
S Sperry ... P Crews
J Nat Prod 1997 Jan; 60(1)29-32.
Score: 0.279
Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro.
Joong Sup Shim ... Ho Jeong Kwon
Cancer Lett 2004 Jan; 203(2)163-9.
Score: 0.279
From natural products to clinically useful antifungals.
David Barrett
Biochim Biophys Acta 2002 Jul; 1587(2-3)224-33.
Score: 0.279
Novel antitumor agents from higher plants.
K H Lee
Med Res Rev 1999 Nov; 19(6)569-96.
Score: 0.279
Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine.
K A Hood ... J H Miller
Apoptosis 2001 Jun; 6(3)207-19.
Score: 0.279
Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery.
Andrew M Piggott ... Peter Karuso
Comb Chem High Throughput Screen 2004 Nov; 7(7)607-30.
Score: 0.279
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.
L Li ... K H Lee
J Med Chem 1994 Sep; 37(20)3400-7.
Score: 0.279
Marine natural products. Pigments.
C W Chang
J Chem Educ 1973 Feb; 50(2)102-6.
Score: 0.278
Bioactive marine natural products, with emphasis on handling of water-soluble compounds.
Y Shimizu
J Nat Prod 1985 Mar-Apr; 48(2)223-35.
Score: 0.278
Marine natural products and biomedicine.
P J Scheuer
Med Res Rev 1989 Oct-Dec; 9(4)535-45.
Score: 0.278
Total synthesis of the marine natural product rac-dibromophakellstatin.
Delphine E N Jacquot ... Thomas Lindel
Angew Chem Int Ed Engl 2005 Apr; 44(15)2295-8.
Score: 0.278
Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin.
Richard A Isbrucker ... Amy E Wright
Biochem Pharmacol 2003 Jul; 66(1)75-82.
Score: 0.278
Polyketide stereotetrads in natural products.
Ari M P Koskinen ... Kaisa Karisalmi
Chem Soc Rev 2005 Aug; 34(8)677-90.
Score: 0.278
Some hope from marine natural products.
M D'Incalci
Ann Oncol 1998 Sep; 9(9)937-8.
Score: 0.278
Natural products from Marine microorganisms.
Ute Hentschel
Chembiochem 2002 Nov; 3(11)1151-4.
Score: 0.278
Development and characterization of proteasome inhibitors.
Kyung Bo Kim ... Craig M Crews
Methods Enzymol 2005 ; 399()585-609.
Score: 0.277
Total syntheses and biological investigations of tamandarins A and B and tamandarin A analogs.
B Liang ... M M Joullié
J Am Chem Soc 2001 May; 123(19)4469-74.
Score: 0.276
Drugs from the sea: conotoxins as drug leads for neuropathic pain and other neurological conditions.
D Alonso ... B G Livett
Mini Rev Med Chem 2003 Nov; 3(7)785-7.
Score: 0.276
Natural product hybrids as new leads for drug discovery.
Lutz F Tietze ... Srivari Chandrasekhar
Angew Chem Int Ed Engl 2003 Sep; 42(34)3996-4028.
Score: 0.276
Advanced preclinical and clinical trials of natural products and related compounds from marine sources.
David J Newman ... Gordon M Cragg
Curr Med Chem 2004 Jul; 11(13)1693-713.
Score: 0.276
Natural products in the process of finding new drug candidates.
P Vuorelaa ... H Vuorela
Curr Med Chem 2004 Jun; 11(11)1375-89.
Score: 0.276
Natural organic compounds that affect to microtubule functions.
S Iwasaki
Yakugaku Zasshi 1998 Apr; 118(4)112-26.
Score: 0.276
Natural products research: perspectives from a major pharmaceutical company.
R P Borris
J Ethnopharmacol 1996 Apr; 51(1-3)29-38.
Score: 0.275
Archazolid and apicularen: novel specific V-ATPase inhibitors.
Markus Huss ... Helmut Wieczorek
BMC Biochem 2005 ; 6()13.
Score: 0.275
Optimization of experimental antimitotic agents: classical and combinatorial methods.
Nathanael S Gray
Prog Cell Cycle Res 2003 ; 5()135-43.
Score: 0.275
Microtubule-stabilizing agents based on designed laulimalide analogues.
Susan L Mooberry ... Paul A Wender
Proc Natl Acad Sci U S A 2004 Jun; 101(23)8803-8.
Score: 0.275
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.
K Chen ... K H Lee
J Med Chem 1997 Sep; 40(19)3049-56.
Score: 0.275
Synthesis and antitumor evaluation of symmetrical 1,5-diamidoanthraquinone derivatives as compared to their disubstituted homologues.
Hsu-Shan Huang ... In-Been Chen
Chem Pharm Bull (Tokyo) 2006 Apr; 54(4)458-64.
Score: 0.274
Halipeptins A and B: two novel potent anti-inflammatory cyclic depsipeptides from the Vanuatu marine sponge Haliclona species.
A Randazzo ... L Gomez-Paloma
J Am Chem Soc 2001 Nov; 123(44)10870-6.
Score: 0.274
Rationally designed anti-mitotic agents with pro-apoptotic activity.
F M Uckun
Curr Pharm Des 2001 Nov; 7(16)1627-39.
Score: 0.274
Cytotoxic bromoindole derivatives and terpenes from the Philippine marine sponge Smenospongia sp.
Deniz Tasdemir ... Chris M Ireland
Z Naturforsch [C] 2002 Sep-Oct; 57(9-10)914-22.
Score: 0.273
Marine natural products. XXIII. Three new cytotoxic dimeric macrolides, swinholides B and C and isoswinholide A, congeners of swinholide A, from the Okinawan marine sponge Theonella swinhoei.
M Kobayashi ... I Kitagawa
Chem Pharm Bull (Tokyo) 1990 Nov; 38(11)2960-6.
Score: 0.273
Marine invertebrates, chemical signals, and marine products.
J E McCauley
Lloydia 1969 Dec; 32(4)425-37.
Score: 0.273
Synthesis and biological evaluation of a natural ester sintenin and its synthetic analogues.
Li Hong Hu ... Yu Zhao
J Nat Prod 2005 Mar; 68(3)342-8.
Score: 0.273
Synthesis of immunomodulatory marine natural products.
S J Danishefsky ... D Trauner
Ernst Schering Res Found Workshop 2000 ; (32)1-24.
Score: 0.273
First total synthesis of a natural product containing a chiral, beta-diketone: synthesis and stereochemical reassignment of siphonarienedione and siphonarienolone.
Michael A Calter ... Wensheng Liao
J Am Chem Soc 2002 Nov; 124(44)13127-9.
Score: 0.273
Cytotoxic pyrrolo- and furanoterpenoids from the sponge sarcotragus species.
Yonghong Liu ... Jee H Jung
J Nat Prod 2002 Sep; 65(9)1307-14.
Score: 0.272
Bioactive agents from natural sources: trends in discovery and application.
S Grabley ... R Thiericke
Adv Biochem Eng Biotechnol 1999 ; 64()101-54.
Score: 0.272
Anti-inflammatory metabolites from marine sponges.
Robert A Keyzers ... Michael T Davies-Coleman
Chem Soc Rev 2005 Apr; 34(4)355-65.
Score: 0.272
Marine microorganisms as a source of new natural products.
V S Bernan ... W M Maiese
Adv Appl Microbiol 1997 ; 43()57-90.
Score: 0.272
Total syntheses of colchicine in comparison: a journey through 50 years of synthetic organic chemistry.
Timm Graening ... Hans-Günther Schmalz
Angew Chem Int Ed Engl 2004 Jun; 43(25)3230-56.
Score: 0.271
Three more cyclotheonamides, C, D, and E, potent thrombin inhibitors from the marine sponge Theonella swinhoei.
Y Nakao ... N Fusetani
Bioorg Med Chem 1995 Aug; 3(8)1115-22.
Score: 0.271
In vitro assays for anticancer drug discovery--a novel approach based on engineered mammalian cell lines.
Valeria Gonzalez-Nicolini ... Martin Fussenegger
Anticancer Drugs 2005 Mar; 16(3)223-8.
Score: 0.271
New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde.
M A Rashid ... M R Boyd
J Nat Prod 2001 Nov; 64(11)1454-6.
Score: 0.271
Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis.
S P Gunasekera ... R E Longley
J Nat Prod 1989 Jul-Aug; 52(4)757-61.
Score: 0.270
Cytotoxic effect (on tumor cells) and in vitro antiviral activity against herpes simplex virus of synthetic spongiane diterpenes.
Liliana Betancur-Galvis ... Ramón J Zaragozá
J Nat Prod 2002 Feb; 65(2)189-92.
Score: 0.270
Natural cytotoxicity in humans: susceptibility of freshly isolatd tumor cells to lysis.
B M Vose ... M Moore
J Natl Cancer Inst 1980 Aug; 65(2)257-63.
Score: 0.270
Synthesis and properties of allenic natural products and pharmaceuticals.
Anja Hoffmann-Röder ... Norbert Krause
Angew Chem Int Ed Engl 2004 Feb; 43(10)1196-216.
Score: 0.270
Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine.
Christine Brahic ... Evelyne Delfourne
Bioorg Med Chem 2002 Sep; 10(9)2845-53.
Score: 0.270
Subcellular metabolite profiles of the parent CCRF-CEM and the derived CEM/C2 cell lines after treatment with doxorubicin.
Adrian B Anderson ... Edgar A Arriaga
J Chromatogr B Analyt Technol Biomed Life Sci 2004 Sep; 808(2)295-302.
Score: 0.269
Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp.
C Y Chen ... C Y Duh
J Nat Prod 1999 Apr; 62(4)573-6.
Score: 0.269
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
S X Zhang ... K H Lee
J Med Chem 1999 Oct; 42(20)4081-7.
Score: 0.269
Sphingolipids in anticancer therapy.
José M Padrón
Curr Med Chem 2006 ; 13(7)755-70.
Score: 0.269
The in vitro biological activities of synthetic 18-O-methyl mycalamide B, 10-epi-18-O-methyl mycalamide B and pederin.
A Richter ... D E Davies
Anticancer Drug Des 1997 Apr; 12(3)217-27.
Score: 0.269
Cytotoxic activity of synthetic aza alkyl lysophospholipids against drug sensitive and drug resistant human tumor cell lines.
H Morimoto ... B Bonavida
Anticancer Res 1991 Nov-Dec; 11(6)2223-9.
Score: 0.268
Cytotoxic polyacetylenes from the marine sponge Petrosia sp.
J S Kim ... H Lee
J Nat Prod 1999 Apr; 62(4)554-9.
Score: 0.268
Biological effects of tolytoxin (6-hydroxy-7-O-methyl-scytophycin b), a potent bioactive metabolite from cyanobacteria.
G M Patterson ... S Carmeli
Arch Microbiol 1992 ; 157(5)406-10.
Score: 0.268
Natural product source material use in the pharmaceutical industry: the Glaxo experience.
D M Turner
J Ethnopharmacol 1996 Apr; 51(1-3)39-43; discussion 44.
Score: 0.268
Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent.
W W Li ... J R Bertino
Clin Cancer Res 2001 Sep; 7(9)2908-11.
Score: 0.267
Chemistry and biological activity of natural and synthetic prenyloxycoumarins.
Massimo Curini ... Giovanni Giannone
Curr Med Chem 2006 ; 13(2)199-222.
Score: 0.267
Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides.
B Veronesi ... M Ehrich
Toxicol Appl Pharmacol 1993 Jun; 120(2)240-6.
Score: 0.267
Marine natural products and related compounds in clinical and advanced preclinical trials.
David J Newman ... Gordon M Cragg
J Nat Prod 2004 Aug; 67(8)1216-38.
Score: 0.267
Aquaculture of "non-food organisms" for natural substance production.
Gerd Liebezeit
Adv Biochem Eng Biotechnol 2005 ; 97()1-28.
Score: 0.267
Enzyme inhibitors of marine microbial origin with pharmaceutical importance.
Chiaki Imada
Mar Biotechnol (NY) 2004 May-Jun; 6(3)193-8.
Score: 0.267
Antibiotic resistance versus small molecules, the chemical evolution.
V J Lee ... S J Hecker
Med Res Rev 1999 Nov; 19(6)521-42.
Score: 0.266
(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities.
Anders Vik ... Lars Bohlin
J Nat Prod 2006 Mar; 69(3)381-6.
Score: 0.266
Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity.
Jeffrey D Neighbors ... David F Wiemer
Bioorg Med Chem 2006 Mar; 14(6)1771-84.
Score: 0.265
Biomimicry as a basis for drug discovery.
V M Kolb
Prog Drug Res 1998 ; 51()185-217.
Score: 0.265
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
Y T Chang ... P G Schultz
Chem Biol 1999 Jun; 6(6)361-75.
Score: 0.265
Biological evaluation of cryptophycin 52 fragment A analogues: effect of the multidrug resistance ATP binding cassette transporters on antitumor activity.
Rima S Al-Awar ... Daniel C Williams
Mol Cancer Ther 2004 Sep; 3(9)1061-7.
Score: 0.265
Antitumor properties of podophyllotoxin and related compounds.
M Gordaliza ... A S Feliciano
Curr Pharm Des 2000 Dec; 6(18)1811-39.
Score: 0.265
Synthesis and biological activity of new class of dioxygenated anticancer agents.
Maria Dolors Pujol ... Isabel Sánchez
Curr Med Chem Anticancer Agents 2005 May; 5(3)215-37.
Score: 0.265
New lysophosphatidylcholines and monoglycerides from the marine sponge Stelletta sp.
Qingchun Zhao ... Jee H Jung
J Nat Prod 2003 May; 66(5)725-8.
Score: 0.265
Synthesis of the core structure of salicylihalamide A by intramolecular Suzuki reaction.
Matthias Bauer ... Martin E Maier
Org Lett 2002 Jun; 4(13)2205-8.
Score: 0.265
Combretastatin A-4 analogues as antimitotic antitumor agents.
Nguyen-Hai Nam
Curr Med Chem 2003 Sep; 10(17)1697-722.
Score: 0.265
Synthesis of nonracemic 3-deoxyschweinfurthin B.
Jeffrey D Neighbors ... David F Wiemer
J Org Chem 2005 Feb; 70(3)925-31.
Score: 0.264
Antibacterial activity against resistant bacteria and cytotoxicity of four alkaloid toxins isolated from the marine sponge Arenosclera brasiliensis.
Yohandra R Torres ... Manoel O de Moraes
Toxicon 2002 Jul; 40(7)885-91.
Score: 0.264
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
R E Longley ... D Harmody
J Nat Prod 1993 Jun; 56(6)915-20.
Score: 0.264
Microbial symbionts of marine invertebrates: opportunities for microbial biotechnology.
M G Haygood ... D J Faulkner
J Mol Microbiol Biotechnol 1999 Aug; 1(1)33-43.
Score: 0.264
5,6:8,9-diepoxy and other cytotoxic sterols from the marine sponge Homaxinella sp.
Tayyab A Mansoor ... Jee H Jung
J Nat Prod 2006 Jan; 69(1)131-4.
Score: 0.264
Structural revision of sulfated polysaccharide B-1 isolated from a marine Pseudomonas species and its cytotoxic activity against human cancer cell lines.
Masahiro Matsuda ... Koichi Okutani
Mar Biotechnol (NY) 2003 Jan-Feb; 5(1)13-9.
Score: 0.264
Drugs from the seas - current status and microbiological implications.
P Proksch ... R Ebel
Appl Microbiol Biotechnol 2002 Jul; 59(2-3)125-34.
Score: 0.264
A marine natural product inhibitor of kinesin motors.
R Sakowicz ... L S Goldstein
Science 1998 Apr; 280(5361)292-5.
Score: 0.264
Total synthesis of hectochlorin.
Jeannie R P Cetusic ... M Paige Oliver
Org Lett 2002 Apr; 4(8)1307-10.
Score: 0.264
Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells.
C Arnaudeau ... T Helleday
Mutat Res 2000 Nov; 461(3)221-8.
Score: 0.264
Small-molecule inhibitors of the cell cycle: an overview.
Craig M Crews ... J Brad Shotwell
Prog Cell Cycle Res 2003 ; 5()125-33.
Score: 0.263
Furano pyrimidines as novel potent and selective anti-VZV agents.
C McGuigan ... J Balzarini
Antivir Chem Chemother 2001 Mar; 12(2)77-89.
Score: 0.263
Sesquiterpenes: natural products that decrease cancer growth.
Aneta Modzelewska ... Saeed R Khan
Curr Med Chem Anticancer Agents 2005 Sep; 5(5)477-99.
Score: 0.263
Thorectandrols A and B, new cytotoxic sesterterpenes from the marine sponge Thorectandra species.
R D Charan ... M R Boyd
J Nat Prod 2001 May; 64(5)661-3.
Score: 0.263
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
J Guan ... K H Lee
J Med Chem 1998 May; 41(11)1956-61.
Score: 0.263
Large-scale production of pharmaceuticals by marine sponges: sea, cell, or synthesis?
Detmer Sipkema ... René H Wijffels
Biotechnol Bioeng 2005 Apr; 90(2)201-22.
Score: 0.263
Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers.
Carmen Sanmartín ... Juan Antonio Palop
Bioorg Med Chem 2005 Mar; 13(6)2031-44.
Score: 0.263
Antimutagenic agents from natural products of terrestrial and marine origin.
M E Wall ... M C Wani
Basic Life Sci 1993 ; 6