FRISC: The Faculty Research Interests Science Comparator

J. David Farrar, Ph.D.
Assistant Professor, Center for Immunology
Immunology
Office: (214) 648-7315
Lab: 214-648-7316
Fax: 214-648-7331
Email: david.farrar@utsouthwestern.edu

New This Month | New This Year | Abstract | Selected Publications | FRISC Statistics Results - FULL MEDLINE:

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 Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.
J D Farrar ... K M Murphy
Nat Immunol 2000 Jul; 1(1)65-9.
Score: 0.591
A role for CD4 in peripheral T cell differentiation.
D R Brown ... S L Reiner
J Exp Med 1997 Jul; 186(1)101-7.
Score: 0.547
Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection.
Ashraful Haque ... Gregory J Bancroft
J Infect Dis 2006 Feb; 193(3)370-9.
Score: 0.505
What it takes to become an effector T cell: the process, the cells involved, and the mechanisms.
M A Santana ... Y Rosenstein
J Cell Physiol 2003 Jun; 195(3)392-401.
Score: 0.484
Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells.
Yoichi Maekawa ... Koji Yasutomo
Immunity 2003 Oct; 19(4)549-59.
Score: 0.483
Cytokines in parasitic diseases: the example of cutaneous leishmaniasis.
P Launois ... J A Louis
Int Rev Immunol 1998 ; 17(1-4)157-80.
Score: 0.468
IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88.
Stephanie C Eisenbarth ... Kim Bottomly
J Immunol 2004 Apr; 172(7)4527-34.
Score: 0.465
The development of CD4+ T effector cells during the type 2 immune response.
W C Gause ... J F Urban
Immunol Res 1999 ; 20(1)55-65.
Score: 0.465
Type I interferons and the Th1/Th2 paradigm.
F Sinigaglia ... L Rogge
Dev Comp Immunol 1999 Oct-Dec; 23(7-8)657-63.
Score: 0.459
Toll-like receptor signaling and regulation of cytokine gene expression in the immune system.
Keiko Ozato ... Tomohiko Tamura
Biotechniques 2002 Oct; Suppl()66-8, 70, 72 passim.
Score: 0.449
Notch signaling is an important regulator of type 2 immunity.
Lili Tu ... Warren S Pear
J Exp Med 2005 Oct; 202(8)1037-42.
Score: 0.448
Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production.
Nathalie Bendriss-Vermare ... Francine Brière
J Leukoc Biol 2005 Oct; 78(4)954-66.
Score: 0.447
IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene.
Meredith E Persky ... J David Farrar
J Immunol 2005 Jan; 174(1)294-301.
Score: 0.445
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
N G Jacobson ... K M Murphy
J Exp Med 1995 May; 181(5)1755-62.
Score: 0.441
A multiple transgenic mouse model with a partially humanized activation pathway for helper T cell responses.
R Laub ... F Emmrich
J Immunol Methods 2000 Dec; 246(1-2)37-50.
Score: 0.439
Interferon activation and innate immunity.
C Le Page ... J Hiscott
Rev Immunogenet 2000 ; 2(3)374-86.
Score: 0.439
Natural interferon alpha/beta-producing cells link innate and adaptive immunity.
N Kadowaki ... Y J Liu
J Exp Med 2000 Jul; 192(2)219-26.
Score: 0.437
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.
D D Yang ... R A Flavell
Immunity 1998 Oct; 9(4)575-85.
Score: 0.437
Dendritic cells prime in vivo alloreactive CD4 T lymphocytes toward type 2 cytokine- and TGF-beta-producing cells in the absence of CD8 T cell activation.
G Foucras ... J C Guéry
J Immunol 2000 Nov; 165(9)4994-5003.
Score: 0.435
Polarized development of memory cell-like IFN-gamma-producing cells in the absence of TCR zeta-chain.
Ludmila Krymskaya ... Chih-Pin Liu
J Immunol 2005 Feb; 174(3)1188-95.
Score: 0.435
Signaling through the T1/ST2 molecule is not necessary for Th2 differentiation but is important for the regulation of type 1 responses in nonhealing Leishmania major infection.
P Kropf ... I Müller
Infect Immun 2003 Apr; 71(4)1961-71.
Score: 0.435
Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation.
Natallia Mikhalkevich ... Wei-ping Zheng
J Immunol 2006 Feb; 176(3)1553-60.
Score: 0.432
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.
F Powrie ... R L Coffman
J Exp Med 1996 Jun; 183(6)2669-74.
Score: 0.428
[The Th1/Th2 concept--its importance for regulation of IgE]
H Haas ... M Schlaak
Immun Infekt 1994 Jun; 22(3)88-93.
Score: 0.424
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.
S Constant ... K Bottomly
J Exp Med 1995 Nov; 182(5)1591-6.
Score: 0.422
Notch1 expression on T cells is not required for CD4+ T helper differentiation.
Fabienne Tacchini-Cottier ... Freddy Radtke
Eur J Immunol 2004 Jun; 34(6)1588-96.
Score: 0.422
Stat5a regulates T helper cell differentiation by several distinct mechanisms.
S Kagami ... I Iwamoto
Blood 2001 Apr; 97(8)2358-65.
Score: 0.421
Development of Th1-type immune responses requires the type I cytokine receptor TCCR.
Q Chen ... F J de Sauvage
Nature 2000 Oct; 407(6806)916-20.
Score: 0.421
Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1.
S Diehl ... M Rincón
Immunity 2000 Dec; 13(6)805-15.
Score: 0.420
Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.
M C Nawijn ... R W Hendriks
J Immunol 2001 Jul; 167(2)724-32.
Score: 0.420
Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo.
Phyllis-Jean Linton ... Linda M Bradley
J Exp Med 2003 Apr; 197(7)875-83.
Score: 0.419
[Cytokines and immune response]
L Pelletier ... P Druet
Rev Prat 1993 Mar; 43(5)536-46.
Score: 0.418
Signal transduction in T helper cells: CD4 coreceptors exert complex regulatory effects on T cell activation and function.
Rolf König ... Wenhong Zhou
Curr Issues Mol Biol 2004 Jan; 6(1)1-15.
Score: 0.417
Massive production of Th2 cytokines by human CD4+ effector T cells transiently expressing the natural killer cell marker CD57/HNK1.
V Brinkmann ... C Kristofic
Immunology 1997 Aug; 91(4)541-7.
Score: 0.416
T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling.
R Nishikomori ... W Strober
J Exp Med 2000 Mar; 191(5)847-58.
Score: 0.415
Mechanisms of Type I interferon cell signaling and STAT-mediated transcriptional responses.
Joe F Lau ... Curt M Horvath
Mt Sinai J Med 2002 May; 69(3)156-68.
Score: 0.414
The function of the CD4 coreceptor in the development of T cells.
N Killeen ... D R Littman
Int Rev Immunol 1995 ; 13(1)15-27.
Score: 0.414
The two faces of IL-6 on Th1/Th2 differentiation.
Sean Diehl ... Mercedes Rincón
Mol Immunol 2002 Dec; 39(9)531-6.
Score: 0.414
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Yoh-Ichi Seki ... Masato Kubo
Proc Natl Acad Sci U S A 2002 Oct; 99(20)13003-8.
Score: 0.413
Chromatin remodeling and T helper subset differentiation.
S Miyatake ... K Arai
IUBMB Life 2000 Jun; 49(6)473-8.
Score: 0.413
Protection against the early acute phase of Cryptosporidium parvum infection conferred by interleukin-4-induced expression of T helper 1 cytokines.
Stuart A C McDonald ... Vincent McDonald
J Infect Dis 2004 Sep; 190(5)1019-25.
Score: 0.413
IL-4-mediated inhibition of IFN-gamma production by CD4+ T cells proceeds by several developmentally regulated mechanisms.
Olivier Wurtz ... Sylvie Guerder
Int Immunol 2004 Mar; 16(3)501-8.
Score: 0.412
Subsets of CD4 T cells and B cell activation.
K Bottomly
Semin Immunol 1989 Sep; 1(1)21-31.
Score: 0.412
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.
Davide Agnello ... David M Frucht
J Clin Immunol 2003 May; 23(3)147-61.
Score: 0.412
Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.
B P Mahon ... K H Mills
J Exp Med 1995 Apr; 181(4)1285-92.
Score: 0.412
Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.
T Sornasse ... H Yssel
J Exp Med 1996 Aug; 184(2)473-83.
Score: 0.411
Crossregulation between Th1 and Th2 cells.
P A Morel ... T B Oriss
Crit Rev Immunol 1998 ; 18(4)275-303.
Score: 0.411
Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.
S J Szabo ... K M Murphy
Immunity 1995 Jun; 2(6)665-75.
Score: 0.410
ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling.
Masashi Watanabe ... Ryo Abe
J Immunol 2005 Feb; 174(4)1989-96.
Score: 0.409
The biology of IL-12: coordinating innate and adaptive immune responses.
Wendy T Watford ... John J O'Shea
Cytokine Growth Factor Rev 2003 Oct; 14(5)361-8.
Score: 0.408
Regulation of CD4 T cell reactivity to self and non-self.
D Lo ... L Burkly
Int Rev Immunol 1995 ; 13(2)147-60.
Score: 0.407
Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells.
Karim Dabbagh ... David B Lewis
J Immunol 2002 May; 168(9)4524-30.
Score: 0.407
Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy.
A A Ashkar ... B A Croy
Semin Immunol 2001 Aug; 13(4)235-41.
Score: 0.407
Endogenous IL-4 and IFN-gamma are essential for expression of Th2, but not Th1 cytokine message during the early differentiation of human CD4+ T helper cells.
Karen C L Torres ... Kenneth J Gollob
Hum Immunol 2004 Nov; 65(11)1328-35.
Score: 0.407
The function of type I interferons in antimicrobial immunity.
C Bogdan
Curr Opin Immunol 2000 Aug; 12(4)419-24.
Score: 0.404
Regulation of T helper cell differentiation by STAT molecules.
M H Kaplan ... M J Grusby
J Leukoc Biol 1998 Jul; 64(1)2-5.
Score: 0.404
Signaling and cell death in lymphocytes.
R A Flavell ... R J Davis
Inflamm Res 2002 Feb; 51(2)80-2.
Score: 0.404
A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells.
M Whelan ... K P Rigley
J Immunol 2000 Jun; 164(12)6453-60.
Score: 0.403
Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation.
N Noben-Trauth ... W E Paul
J Immunol 2000 Oct; 165(7)3620-5.
Score: 0.402
Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.
S L Constant ... K Bottomly
Annu Rev Immunol 1997 ; 15()297-322.
Score: 0.401
Cooperation between CD4+ and CD8+ T cells: when, where, and how.
Flora Castellino ... Ronald N Germain
Annu Rev Immunol 2006 ; 24()519-40.
Score: 0.401
Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease.
S Romagnani
Int J Clin Lab Res 1991 ; 21(2)152-8.
Score: 0.401
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity.
Jennifer E Fenner ... Paul J Hertzog
Nat Immunol 2006 Jan; 7(1)33-9.
Score: 0.400
Combination of HIV-1-specific CD4 Th1 cell responses and IgG2 antibodies is the best predictor for persistence of long-term nonprogression.
Valérie Martinez ... Brigitte Autran
J Infect Dis 2005 Jun; 191(12)2053-63.
Score: 0.400
Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major.
P Launois ... J A Louis
Parasite Immunol 1998 May; 20(5)223-30.
Score: 0.400
CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR.
D Leitenberg ... K Bottomly
J Immunol 1998 Aug; 161(3)1194-203.
Score: 0.400
A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells.
M H Kaplan ... M J Grusby
J Exp Med 1998 Sep; 188(6)1191-6.
Score: 0.400
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.
M H Kaplan ... M J Grusby
Nature 1996 Jul; 382(6587)174-7.
Score: 0.399
Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production.
T Yoshimoto ... W E Paul
Science 1995 Dec; 270(5243)1845-7.
Score: 0.399
Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment.
Takanori So ... Michael Croft
Proc Natl Acad Sci U S A 2006 Mar; 103(10)3740-5.
Score: 0.399
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.
Z E Wang ... R M Locksley
J Exp Med 1994 Apr; 179(4)1367-71.
Score: 0.398
Stability and commitment in T helper cell development.
H Asnagli ... K M Murphy
Curr Opin Immunol 2001 Apr; 13(2)242-7.
Score: 0.397
Early interactions between blood-stage plasmodium parasites and the immune system.
B C Urban ... M M Stevenson
Curr Top Microbiol Immunol 2005 ; 297()25-70.
Score: 0.397
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.
W Zheng ... R A Flavell
Cell 1997 May; 89(4)587-96.
Score: 0.396
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
R M Locksley ... N Killeen
Science 1993 Sep; 261(5127)1448-51.
Score: 0.396
CD4 T cell responses to influenza infection.
Deborah M Brown ... Susan L Swain
Semin Immunol 2004 Jun; 16(3)171-7.
Score: 0.396
The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.
Toshiki Tamura ... Kiyoshi Takatsu
Int Immunol 2004 Dec; 16(12)1691-9.
Score: 0.395
Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation.
Ronald B Smeltz ... Ethan M Shevach
Immunology 2005 Apr; 114(4)484-92.
Score: 0.395
Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets.
E A Bach ... R D Schreiber
Science 1995 Nov; 270(5239)1215-8.
Score: 0.395
Interferon gamma signaling alters the function of T helper type 1 cells.
G Z Tau ... P B Rothman
J Exp Med 2000 Oct; 192(7)977-86.
Score: 0.395
A potential pathway of Th2 development during primary immune response. IL-10 pretreated dendritic cells can prime naive CD4+ T cells to secrete IL-4.
L Liu ... H L Weiner
Adv Exp Med Biol 1997 ; 417()375-81.
Score: 0.394
Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.
A E Wakil ... R M Locksley
J Exp Med 1998 Nov; 188(9)1651-6.
Score: 0.394
IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background.
D Xu ... F Y Liew
Eur J Immunol 2000 Nov; 30(11)3147-56.
Score: 0.394
Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4.
S Zhang ... M H Kaplan
J Immunol 2000 Jul; 165(1)10-4.
Score: 0.393
IL-4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation.
Nancy Noben-Trauth ... William E Paul
Eur J Immunol 2002 May; 32(5)1428-33.
Score: 0.393
[Importance of the different T lymphocytes subsets in immunity of mice against an intracellular protozoan parasite: Leishmania major]
J A Louis
Pathol Biol (Paris) 1993 Oct; 41(8 Pt 2)812-6.
Score: 0.393
Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.
L M Webb ... M Feldmann
Eur J Immunol 1997 Mar; 27(3)633-40.
Score: 0.392
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.
D H Zhang ... A Ray
J Biol Chem 1997 Aug; 272(34)21597-603.
Score: 0.392
Monoclonal antibody against IFN-gamma inhibits Moloney murine sarcoma virus-specific cytotoxic T lymphocyte differentiation.
P Zanovello ... D Collavo
J Immunol 1988 Feb; 140(4)1341-4.
Score: 0.392
Endogenous interleukin 4 is required for development of protective CD4+ T helper type 1 cell responses to Candida albicans.
A Mencacci ... L Romani
J Exp Med 1998 Feb; 187(3)307-17.
Score: 0.392
Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells.
P A Knolle ... A W Lohse
Gastroenterology 1999 Jun; 116(6)1428-40.
Score: 0.391
Interferon research: a brief history.
Myriam S Kunzi ... Paula M Pitha
Methods Mol Med 2005 ; 116()25-35.
Score: 0.391
Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.
M B Graham ... T J Braciale
J Exp Med 1994 Oct; 180(4)1273-82.
Score: 0.391
Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells.
L L Carter ... K M Murphy
J Exp Med 1999 Apr; 189(8)1355-60.
Score: 0.391
Selective differentiation of CD4+ T helper cell subsets.
P Scott
Curr Opin Immunol 1993 Jun; 5(3)391-7.
Score: 0.391
CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells.
Christophe Filippi ... Sophie Ugolini
J Exp Med 2003 Jul; 198(2)201-9.
Score: 0.390
Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus.
Dipak R Patel ... Cheong-Hee Chang
Cell Immunol 2005 Jan; 233(1)30-40.
Score: 0.390
Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2.
J D Farrar ... K M Murphy
J Biol Chem 2000 Jan; 275(4)2693-7.
Score: 0.390
Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice.
Sara R Fagerlie ... Grover C Bagby
J Immunol 2004 Sep; 173(6)3863-70.
Score: 0.390
Th cells and Th2 responses can develop in the absence of MHC class II-CD4 interactions.
A Wack ... D Kioussis
J Immunol 1999 Aug; 163(3)1162-9.
Score: 0.390
Plasmacytoid dendritic cells: in search of their niche in immune responses.
Winfried Barchet ... Marco Colonna
Immunol Res 2005 ; 32(1-3)75-83.
Score: 0.389
Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4+ populations. Evidence that clones secreting IL-2 and IL-4 give rise to clones which secrete only IL-4.
B E Torbett ... A L Glasebrook
Immunol Lett 1990 Jan; 23(3)227-33.
Score: 0.389
Impaired Th2 subset development in the absence of CD4.
D J Fowell ... R M Locksley
Immunity 1997 May; 6(5)559-69.
Score: 0.389
Disruption of the murine IL-4 gene blocks Th2 cytokine responses.
M Kopf ... G Köhler
Nature 1993 Mar; 362(6417)245-8.
Score: 0.388
CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice.
Damo Xu ... Foo Y Liew
J Immunol 2003 Jan; 170(1)394-9.
Score: 0.388
Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells.
Anagha A Divekar ... Tim R Mosmann
J Immunol 2006 Feb; 176(3)1465-73.
Score: 0.388
Multistage regulation of Th1-type immune responses by the transcription factor IRF-1.
S Taki ... Y Asano
Immunity 1997 Jun; 6(6)673-9.
Score: 0.388
[Immunology of tuberculosis and cytokines]
I Tsuyuguchi
Kekkaku 1995 May; 70(5)335-46.
Score: 0.388
Insights into the ontogeny and activation of T cells.
T W Mak
Clin Chem 1994 Nov; 40(11 Pt 2)2128-31.
Score: 0.387
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.
A Rahemtulla ... R M Zinkernagel
Nature 1991 Sep; 353(6340)180-4.
Score: 0.387
CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity.
Maria P Lemos ... Terri M Laufer
J Immunol 2003 Nov; 171(10)5077-84.
Score: 0.387
The Th1/Th2 balance in autoimmunity.
B Charlton ... K J Lafferty
Curr Opin Immunol 1995 Dec; 7(6)793-8.
Score: 0.387
Immunoregulatory confluence: T cells, Fc receptors and cytokines for IgA immune responses.
H Kiyono ... J R McGhee
Int Rev Immunol 1990 ; 6(4)263-73.
Score: 0.386
From naive to memory. Development and regulation of CD4+ T cell responses.
L L Carter ... S L Swain
Immunol Res 1998 Aug; 18(1)1-13.
Score: 0.386
Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.
N Killeen ... D R Littman
EMBO J 1993 Apr; 12(4)1547-53.
Score: 0.386
Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.
Y Maekawa ... N Katunuma
J Immunol 1998 Sep; 161(5)2120-7.
Score: 0.385
IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils.
Luqiu Chen ... Hua Huang
J Immunol 2004 Feb; 172(4)2059-66.
Score: 0.385
1,25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells.
Teodora P Staeva-Vieira ... Leonard P Freedman
J Immunol 2002 Feb; 168(3)1181-9.
Score: 0.385
Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene.
P Choi ... B J Morley
Genes Immun 2005 Jun; 6(4)290-7.
Score: 0.384
Treatment of allergic airway inflammation and hyperresponsiveness by imiquimod modulating transcription factors T-bet and GATA-3.
Tao Bian ... Wei De
Chin Med J (Engl) 2006 Apr; 119(8)640-8.
Score: 0.384
Stat6 regulation of in vivo IL-4 responses.
F D Finkelman ... J F Urban
J Immunol 2000 Mar; 164(5)2303-10.
Score: 0.384
Induction and regulation of CD4+ T cell subsets.
F Y Liew
Ciba Found Symp 1994 ; 187()170-5; discussion 176-8.
Score: 0.384
Functional characterization of EBV-encoded nuclear antigen 1-specific CD4+ helper and regulatory T cells elicited by in vitro peptide stimulation.
Kui Shin Voo ... Rong-Fu Wang
Cancer Res 2005 Feb; 65(4)1577-86.
Score: 0.384
Role of B7 signaling in the differentiation of naive CD4+ T cells to effector interleukin-4-producing T helper cells.
W C Gause ... P Lu
Immunol Res 1995 ; 14(3)176-88.
Score: 0.384
Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent.
S E Macatonia ... A O'Garra
Int Immunol 1993 Sep; 5(9)1119-28.
Score: 0.383
Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function.
R M Locksley ... P Scott
Immunol Today 1991 Mar; 12(3)A58-61.
Score: 0.383
Immunosuppression by anti-CD4 treatment in vivo. Cellular and humoral responses to alloantigens.
C M Weyand ... C G Fathman
Transplantation 1989 Jun; 47(6)1039-42.
Score: 0.383
Th2-dependent B cell responses in the absence of CD40-CD40 ligand interactions.
N Chirmule ... J M Wilson
J Immunol 2000 Jan; 164(1)248-55.
Score: 0.383
Cutting edge: early IFN-gamma signaling directly enhances primary antiviral CD4+ T cell responses.
Jason K Whitmire ... J Lindsay Whitton
J Immunol 2005 Nov; 175(9)5624-8.
Score: 0.383
Human recombinant interferon-beta influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors.
B L McRae ... G A van Seventer
Eur J Immunol 1997 Oct; 27(10)2650-6.
Score: 0.383
IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.
T Biedermann ... M Röcken
Nat Immunol 2001 Nov; 2(11)1054-60.
Score: 0.383
Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis.
J Anguita ... E Fikrig
J Infect Dis 1998 Nov; 178(5)1512-5.
Score: 0.382
Airway inflammation driven by antigen-specific resident lung CD4(+) T cells in alphabeta-T cell receptor transgenic mice.
P G Knott ... C P Bertrand
Am J Respir Crit Care Med 2000 Apr; 161(4 Pt 1)1340-8.
Score: 0.382
Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis.
S L Reiner ... R M Locksley
J Cell Biochem 1993 Dec; 53(4)323-8.
Score: 0.382
Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.
M Desmedt ... J Grooten
J Immunol 1998 Jun; 160(11)5300-8.
Score: 0.382
Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2.
J M Blander ... C A Janeway
J Exp Med 2000 Jun; 191(12)2065-74.
Score: 0.382
CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling.
D Jankovic ... A Sher
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