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FRISC: The Faculty Research Interests Science Comparator |
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Professor, Eugene McDermott Center for Human Growth and Development and
Departments of Biochemistry and Internal Medicine
Biological Chemistry
Molecular Biophysics
Office: (214) 648-1600
FAX: (214) 648-1666
Email: garner@utsw.swmed.edu
Home Page: Garner Lab
Center
for Biomedical Inventions and the Eugene McDermott Center
for Human Growth and Development
Scientists and students focus on developing new
technologies - instrumentation, methods and software - to exploit the massive amount of
emerging sequence from the Human Genome Project the Cancer Genome Anatomy Project, and
other private ventures.
In our laboratories in the Center for Biomedical Inventions
and the Eugene McDermott Center for Human Growth and Development at UTSW, we have been working on the
following projects: 1) Genomic Analysis software executing on a HP Exemplar superparallel
computer, 2) Digital Optical Chemistry - a new method to produce oligonucleotide arrays
photolithographically, 3) Spotted array technology including a new spotter robot and a
hyperspectral imaging slide reader, 4) A very high performance hyperspectral imaging
microscope, 5) Biochips of various types (electronic hybridization, surface plasmon
resonance), 6) Advances in sequencing technology including a very high throughput DNA
sequencer and a capillary sequencer (with Beckman Instruments), and 7) MerMade - a high
throughput DNA synthesizer.
With the software and instrumentation developed in our lab
we work collaboratively with other faculty at UTSW and researchers off-campus to identify
new cancer genes, investigate gene networks in yeast, develop new vaccines, sequence small
virus/pathogen genomes, study cardiac damage and repair, biological pattern formation,
early and sensitive detection of pathogen contamination and improve cytogenetic analysis.
Our work and available computational tools are available on
the www at http://pompous.swmed.edu/
Selected Publications:
J. W. Fondon III, G. M. Mele, D. Cummings, A. Pande, J.
Wren, K. M. O'Brien, K. C. Kupfer, M. Lerman, J. D. Minna and H.R. Garner (1998)
Computationally Assisted Polymorphic Marker Identification: Identification and
Verification of Multiple New 3p21.3 Polymorphic Markers , Proc. Nat. Acad. Scie. ,
95:7514-7519
K. M. O'Brien, J. J. Schageman, T. H. Major, G. A. Evans
and H.R. Garner (1998) Improving Read Lengths by Recomputing the Matrics of
Model 377 DNA Sequencers, BioTechniques , Vol. 24, No. 6, 1014-1016
S. Rayner, S. Brignac, R. Bumeister, Y. Belodludtsev, T.
Ward, O. Grant, K. O'Brien, G.A. Evans and H.R. Garner (1998) MerMade: A 2 x 96-Well
Plate Oligo Synthesizer For High Throughput Production , Genome Research ,
Vol. 8, 741-747
P. Li, K. Kupfer, C. Davies, D. Burbee, G. A. Evans, and H.
R. Garner, (1997) PRIMO: A Primer Design Program that Applies Base Quality
Statistics for Automated Large-Scale DNA Sequencing, Genomics 40, 476-485
H.R. Garner (1997) Custom Hardware and Software for
Genome Center Operations: From Robotic Control to Databases, included in Automated
Technologies for Genome Characterization , edited by Dr. Tony J. Beugelsdijk
H.R. Garner (1994) Automating the PCR Process,
Chapter 16 in The Polymerase Chain Reaction , K. Mullis, F. Ferre, R. Gibbs
editors
Page maintained by Stephanie
Robertson
Last updated: 17 Nov 2000
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted keyword count
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Database: Medline abstracts (1967 - Present)
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Sort by: Score
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Show: Top 100 hits
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Results computed on: 6/9/2006