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FRISC: The Faculty Research Interests Science Comparator |
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Assistant Professor, Center for Basic Neuroscience
Office: 214-648-5133
FAX: 214-648-1801
Building: NB, Room: 4.108
Email: jay.gibson@utsouthwestern.edu
I am interested in the neuronal circuitry of sensory
neocortex. Ultimately, I want to understand how neocortical circuitry
mediates normal processes such as perception, attention, and learning. In
addition, I would like to understand how problems in neocortical circuitry
contribute to some pathological conditions such as epilepsy. In my lab,
electrophysiological techniques, both in vivo and in the brain slice, are used
to address these issues.
Currently, I am focusing on a particular class of
neocortical neuron - the inhibitory interneuron. There are different
subtypes of inhibitory neurons, and very little is known about the function of
each. I am interested in describing their cellular, synaptic, and network
properties to better understand their role in cortical processing. If
possible, I would like to study their activity in the intact animal. This
would include the measurement of responses to sensory stimuli. Rats and
mice are used to answer these questions because of the many experimental
techniques available and because of their similarity to the human brain.
Selected Publications:
Gibson, J. R. and Connors, B. W. Properties of
electrical coupling between layer 4 inhibitory interneurons in sensory cortex. In
preparation .
Beierlein, M., Gibson, J. R., and Connors, B. W. (2000)
An electrically coupled network of interneurons drives synchronized inhibition
in neocortex. Nature Neuroscience ,
3(9): 904-910.
Gibson, J. R., Beierlein, M., Connors, B. W. (1999)
Two electrically coupled inhibitory networks. Nature
402(4): 75-79.
Varela, J. A., Sen, K., Gibson, J., Fost, J., Abbot, L. F.,
Nelson, S. B. (1997) A quantitative description of short-term plasticity
at excitatory synapses in layer 2/3 of rat primary visual cortex. J.
Neuroscience 17(20): 7926-7940.
Gibson, J. R. and Maunsell, J. H. R. (1997) Sensory
modality specificity of neural activity related to memory in visual cortex.
J. Neurophysiol. 78(3): 1263-1275.
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted keyword count
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Database: Medline abstracts (1967 - Present)
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Sort by: Score
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Show: Top 100 hits
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Results computed on: 6/9/2006