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FRISC: The Faculty Research Interests Science Comparator
Alfred G. Gilman, M.D., Ph.D.
Professor of Pharmacology
Cell Regulation
Office: (214) 648-2370
FAX: (214) 648-8812
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Results - FULL MEDLINE:
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits.
W J Tang ... A G Gilman
Science 1991 Dec; 254(5037)1500-3.
Score: 1.028
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits.
A D Federman ... H R Bourne
Nature 1992 Mar; 356(6365)159-61.
Score: 0.977
Inhibition of adenylyl cyclase by Gi alpha.
R Taussig ... A G Gilman
Science 1993 Jul; 261(5118)218-21.
Score: 0.919
A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits.
J Chen ... R H Stoffel
Science 1995 May; 268(5214)1166-9.
Score: 0.855
Reconstitution of muscarinic receptor-mediated inhibition of adenylyl cyclase.
M R Tota ... M I Schimerlik
Mol Pharmacol 1990 Jun; 37(6)950-7.
Score: 0.853
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
R Taussig ... A G Gilman
J Biol Chem 1994 Feb; 269(8)6093-100.
Score: 0.826
Beta subunit copurifies with GppNHp-activated adenylyl cyclase.
I Marbach ... A Levitzki
J Biol Chem 1990 Jun; 265(17)9999-10004.
Score: 0.775
The adenylyl cyclase family.
J Krupinski
Mol Cell Biochem 1991 May 29-Jun 12; 104(1-2)73-9.
Score: 0.770
The GppNHp-activated adenylyl cyclase complex from turkey erythrocyte membranes can be isolated with its beta gamma subunits.
A Bar-Sinai ... A Levitzki
Eur J Biochem 1992 Jul; 207(2)703-8.
Score: 0.767
Adenylyl cyclase assay for beta gamma subunits of G proteins.
J Chen ... R Iyengar
Methods Enzymol 1994 ; 237()451-6.
Score: 0.756
Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z.
T Kozasa ... A G Gilman
J Biol Chem 1995 Jan; 270(4)1734-41.
Score: 0.750
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.
M E Linder ... A G Gilman
J Biol Chem 1990 May; 265(14)8243-51.
Score: 0.740
Adenylyl cyclase, G proteins, and guanylyl cyclase.
Methods Enzymol 1991 ; 195()1-474.
Score: 0.739
Complexity and diversity of mammalian adenylyl cyclases.
R K Sunahara ... A G Gilman
Annu Rev Pharmacol Toxicol 1996 ; 36()461-80.
Score: 0.730
Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma.
J D Hildebrandt ... R E Kohnken
J Biol Chem 1990 Jun; 265(17)9825-30.
Score: 0.729
Identification of functional domains of adenylyl cyclase using in vivo chimeras.
L R Levin ... R R Reed
J Biol Chem 1995 Mar; 270(13)7573-9.
Score: 0.726
The NH2-terminal alpha subunit attenuator domain confers regulation of G protein activation by beta gamma complexes.
N Dhanasekaran ... G L Johnson
J Cell Biochem 1991 Dec; 47(4)352-8.
Score: 0.725
Dual regulation of human syncytial adenylyl cyclase.
M M Jacobs ... N P Illsley
Placenta 1992 Mar-Apr; 13(2)123-33.
Score: 0.722
mu-Opioid receptors inhibit dopamine-stimulated activity of type V adenylyl cyclase but enhance dopamine-stimulated activity of type VII adenylyl cyclase.
M Yoshimura ... B Tabakoff
Mol Pharmacol 1996 Jul; 50(1)43-51.
Score: 0.710
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein.
M P Graziano ... A G Gilman
J Biol Chem 1989 Jan; 264(1)409-18.
Score: 0.704
G Protein beta subunit types differentially interact with a muscarinic receptor but not adenylyl cyclase type II or phospholipase C-beta 2/3.
Y Hou ... N Gautam
J Biol Chem 2001 Jun; 276(23)19982-8.
Score: 0.699
Regulation of adenylyl cyclase by noradrenaline and tumour necrosis factor alpha in rat cardiomyocytes.
C Reithmann ... K Werdan
Eur Heart J 1991 Dec; 12 Suppl F()139-42.
Score: 0.698
Regional distribution of guanine nucleotide binding proteins (Gs and Gi alpha) in human brain: correlation with adenylyl cyclase activity.
L T Young ... J J Warsh
Neurochem Int 1993 Mar; 22(3)285-91.
Score: 0.689
Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin.
W J Tang ... A G Gilman
Science 1995 Jun; 268(5218)1769-72.
Score: 0.689
Regulation of adenylyl cyclase by G proteins.
A G Gilman
Adv Second Messenger Phosphoprotein Res 1990 ; 24()51-7.
Score: 0.684
Gi alpha 1 selectively couples somatostatin receptors to adenylyl cyclase in pituitary-derived AtT-20 cells.
M Tallent ... T Reisine
Mol Pharmacol 1992 Mar; 41(3)452-5.
Score: 0.678
A domain on the G protein beta subunit interacts with both adenylyl cyclase 2 and the muscarinic atrial potassium channel.
K Yan ... N Gautam
J Biol Chem 1996 Jul; 271(30)17597-600.
Score: 0.674
Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase.
Shui-Zhong Yan ... Wei-Jen Tang
Methods Enzymol 2002 ; 345()231-41.
Score: 0.670
Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases.
Mark E Hatley ... Roger K Sunahara
Methods Enzymol 2002 ; 345()127-40.
Score: 0.670
Effects of dexamethasone on G protein levels and adenylyl cyclase activity in rat vascular smooth muscle cells.
A R McLellan ... C J Kenyon
J Mol Endocrinol 1992 Dec; 9(3)237-44.
Score: 0.669
Regulation of mammalian adenylyl cyclases by G-protein alpha and beta gamma subunits.
W J Tang ... A G Gilman
Cold Spring Harb Symp Quant Biol 1992 ; 57()135-44.
Score: 0.666
Isoform-specific sensitization of adenylyl cyclase activity by prior activation of inhibitory receptors: role of beta gamma subunits in transducing enhanced activity of the type VI isoform.
J M Thomas ... B B Hoffman
Mol Pharmacol 1996 May; 49(5)907-14.
Score: 0.664
Characterization of GTP-binding proteins coupled to inhibition of adenylyl cyclase in guinea pig tracheal epithelial cells.
J Yang ... M A Levine
Am J Respir Cell Mol Biol 1994 Jun; 10(6)665-72.
Score: 0.664
Activating mutations in the NH2- and COOH-terminal moieties of the Gs alpha subunit have dominant phenotypes and distinguishable kinetics of adenylyl cyclase stimulation.
S K Gupta ... G L Johnson
J Cell Biochem 1991 Dec; 47(4)359-68.
Score: 0.663
Cloning and expression of a widely distributed (type IV) adenylyl cyclase.
B N Gao ... A G Gilman
Proc Natl Acad Sci U S A 1991 Nov; 88(22)10178-82.
Score: 0.661
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
J J Tesmer ... S R Sprang
Science 1997 Dec; 278(5345)1907-16.
Score: 0.660
Stimulation and inhibition of adenylyl cyclase.
C Reithmann ... K H Jakobs
Symp Soc Exp Biol 1990 ; 44()207-24.
Score: 0.659
The inhibition of adenylyl cyclase activity in isolated lung membranes by muscarinic and alpha-adrenoceptor agonists: role of G-protein alpha and beta gamma sub-units.
P A Stevens ... N J Pyne
Cell Signal 1995 Feb; 7(2)157-63.
Score: 0.658
Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins.
J S Chan ... Y H Wong
J Neurochem 1995 Dec; 65(6)2682-9.
Score: 0.658
The adenylyl and guanylyl cyclase superfamily.
J H Hurley
Curr Opin Struct Biol 1998 Dec; 8(6)770-7.
Score: 0.654
Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni.
J D Hildebrandt ... L Birnbaumer
J Biol Chem 1984 Feb; 259(4)2039-42.
Score: 0.654
Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase.
Y Li ... T Kozasa
J Biol Chem 1998 Jun; 273(26)16265-72.
Score: 0.653
Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase.
S B Masters ... H R Bourne
Science 1988 Jul; 241(4864)448-51.
Score: 0.651
Guanine nucleotide dependent and independent reconstitution of G-proteins with adenylate cyclase: stimulation or attenuation of the enzyme by Gi alpha subunits.
D L Newton ... W A Klee
FEBS Lett 1990 Oct; 271(1-2)207-10.
Score: 0.650
Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat.
A Chaudhry ... J G Granneman
Am J Physiol 1991 Aug; 261(2 Pt 2)R403-11.
Score: 0.649
Regulation of adenylyl cyclase from Blastocladiella emersonii by guanine nucleotides.
H Terenzi ... J C Maia
FEBS Lett 1993 Nov; 334(1)9-12.
Score: 0.644
Voltage-sensitive adenylyl cyclase activity in cultured neurons. A calcium-independent phenomenon.
R Reddy ... D R Storm
J Biol Chem 1995 Jun; 270(24)14340-6.
Score: 0.643
Mechanism of inhibition of transducin guanosine triphosphatase activity by vanadate.
Y Kanaho ... M Vaughan
J Biol Chem 1988 Nov; 263(33)17584-9.
Score: 0.641
Identification of a Gialpha binding site on type V adenylyl cyclase.
C W Dessauer ... A G Gilman
J Biol Chem 1998 Oct; 273(40)25831-9.
Score: 0.640
Guanyl nucleotide regulation of hormonally-responsive adenylyl cyclases.
J Abramowitz ... L Birnbaumer
Mol Cell Endocrinol 1979 Dec; 16(3)129-46.
Score: 0.638
Mechanism and properties of inhibition of purified rat brain adenylate cyclase by G protein beta gamma-subunits.
K Enomoto ... T Asakawa
Jpn J Pharmacol 1995 Nov; 69(3)239-50.
Score: 0.636
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
N Ueda ... A G Gilman
J Biol Chem 1994 Feb; 269(6)4388-95.
Score: 0.634
A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: crossover from G protein-coupled inhibition to stimulation.
A H Dittman ... D R Storm
Biochemistry 1994 Feb; 33(4)943-51.
Score: 0.633
Defective guanyl nucleotide-binding protein beta gamma subunits in a forskolin-resistant mutant of the Y1 adrenocortical cell line.
J Mitchell ... B P Schimmer
Proc Natl Acad Sci U S A 1992 Oct; 89(19)8933-7.
Score: 0.632
[Structure of adenylate cyclase and the coupling with the receptor-G protein system]
T Asakawa ... M Takano
Nippon Yakurigaku Zasshi 1993 Feb; 101(2)59-68.
Score: 0.632
Gs alpha meets its target--shedding light on a key signal transduction event.
J J Dumas ... D G Lambright
Structure 1998 Apr; 6(4)407-11.
Score: 0.630
Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha.
M P Graziano ... A G Gilman
J Biol Chem 1989 Sep; 264(26)15475-82.
Score: 0.630
Activated Gs alpha but not Gi alpha prevents the thermal inactivation of adenylyl cyclase in plasma membranes derived from S49 lymphoma cells.
P Kvapil ... L A Ransnäs
FEBS Lett 1994 May; 343(3)208-12.
Score: 0.629
Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels.
R Mattera ... A M Brown
Science 1989 Feb; 243(4892)804-7.
Score: 0.629
Interaction of somatostatin receptors with G proteins and cellular effector systems.
T Reisine ... S Law
Ciba Found Symp 1995 ; 190()160-7; discussion 167-70.
Score: 0.626
The regulation of adenylyl cyclase by receptor-operated G proteins.
A Levitzki ... A Bar-Sinai
Pharmacol Ther 1991 ; 50(3)271-83.
Score: 0.625
Inhibition of hormonally regulated adenylate cyclase by the beta gamma subunit of transducin.
J Bockaert ... M Chabre
EMBO J 1985 Jun; 4(6)1413-7.
Score: 0.625
Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.
S F Law ... T Reisine
Mol Pharmacol 1994 Apr; 45(4)587-90.
Score: 0.623
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.
P J Casey ... A G Gilman
Biochemistry 1989 Jan; 28(2)611-6.
Score: 0.623
G protein beta gamma subunits.
D E Clapham ... E J Neer
Annu Rev Pharmacol Toxicol 1997 ; 37()167-203.
Score: 0.623
A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein.
S Behrends ... D Koesling
J Biol Chem 1995 Sep; 270(36)21109-13.
Score: 0.621
Simultaneous stimulation of GABA and beta adrenergic receptors stabilizes isotypes of activated adenylyl cyclase heterocomplex.
Alain Robichon ... Franck Pelletier
BMC Cell Biol 2004 Jun; 5()25.
Score: 0.618
G proteins: out of the cytoskeletal closet.
M Rodbell
Mt Sinai J Med 1996 Oct-Nov; 63(5-6)381-6.
Score: 0.618
Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes.
M H Rhee ... Z Vogel
J Neurochem 1998 Oct; 71(4)1525-34.
Score: 0.618
Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha.
John J G Tesmer ... Stephen R Sprang
Methods Enzymol 2002 ; 345()198-206.
Score: 0.617
Differential coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G(o)alpha subunits.
J C Migeon ... N M Nathanson
J Biol Chem 1995 Jul; 270(27)16070-4.
Score: 0.617
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.
T Katada ... A G Gilman
J Biol Chem 1984 Mar; 259(6)3586-95.
Score: 0.616
Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae.
J Field ... J Colicelli
Science 1990 Jan; 247(4941)464-7.
Score: 0.615
Pertussis toxin-catalyzed ADP-ribosylation of adenylate cyclase. Effects of guanyl nucleotides and rhodopsin.
J Moss ... M Vaughan
Dev Biol Stand 1985 ; 61()43-9.
Score: 0.615
G proteins in rat liver proliferation during cholestasis.
N Rodriguez-Henche ... J C Prieto
Hepatology 1994 Oct; 20(4 Pt 1)1041-7.
Score: 0.613
The 70-kilodalton adenylyl cyclase-associated protein is not essential for interaction of Saccharomyces cerevisiae adenylyl cyclase with RAS proteins.
J Wang ... T Kataoka
Mol Cell Biol 1992 Nov; 12(11)4937-45.
Score: 0.612
CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.
R Insall ... P Devreotes
J Cell Biol 1994 Sep; 126(6)1537-45.
Score: 0.612
Characterization of the adenylate cyclase of the rat corpus luteum during luteolysis induced by a prostaglandin F2 alpha analogue.
P A Torjesen ... A Aakvaag
Mol Cell Endocrinol 1986 Mar; 44(3)237-42.
Score: 0.611
Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.
R A Cerione ... R J Lefkowitz
J Biol Chem 1986 Jul; 261(20)9514-20.
Score: 0.610
Hormonal regulation of Gi alpha level and adenylyl cyclase responsiveness.
C Reithmann ... K H Jakobs
Br J Clin Pharmacol 1990 ; 30 Suppl 1()118S-120S.
Score: 0.610
Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.
M Pupillo ... P N Devreotes
Mol Biol Cell 1992 Nov; 3(11)1229-34.
Score: 0.609
Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C.
A Katz ... M I Simon
Nature 1992 Dec; 360(6405)686-9.
Score: 0.609
Effect of deletion of the major brain G-protein alpha subunit (alpha(o)) on coordination of G-protein subunits and on adenylyl cyclase activity.
U Mende ... E J Neer
J Neurosci Res 1998 Oct; 54(2)263-72.
Score: 0.604
Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.
R M Huff ... E J Neer
J Biol Chem 1985 Sep; 260(19)10864-71.
Score: 0.602
The structure, catalytic mechanism and regulation of adenylyl cyclase.
J J Tesmer ... S R Sprang
Curr Opin Struct Biol 1998 Dec; 8(6)713-9.
Score: 0.602
Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase.
M E Hatley ... R K Sunahara
J Biol Chem 2000 Dec; 275(49)38626-32.
Score: 0.601
Beta gamma-mediated enhancement of corticotropin-releasing hormone-stimulated adenylyl cyclase activity by activation of gamma-aminobutyric acid(B) receptors in membranes of rat frontal cortex.
P Onali ... M C Olianas
Biochem Pharmacol 2001 Jul; 62(2)183-90.
Score: 0.599
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
J Inglese ... R J Lefkowitz
Proc Natl Acad Sci U S A 1994 Apr; 91(9)3637-41.
Score: 0.598
Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein.
R A Cerione ... M G Caron
Biochemistry 1987 Mar; 26(5)1485-91.
Score: 0.598
Regulation of forskolin interactions with type I, II, V, and VI adenylyl cyclases by Gs alpha.
E M Sutkowski ... K B Seamon
Biochemistry 1994 Nov; 33(43)12852-9.
Score: 0.597
Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and betagamma subunits.
G Zimmermann ... R Taussig
J Biol Chem 1996 Oct; 271(43)27161-6.
Score: 0.596
Plastic adenylyl cyclase.
S B Liggett
Am J Respir Cell Mol Biol 1999 Nov; 21(5)564-6.
Score: 0.595
Pseudomonas exotoxin A prevents beta-adrenoceptor-induced upregulation of Gi protein alpha-subunits and adenylyl cyclase desensitization in rat heart muscle cells.
C Reithmann ... K H Jakobs
Mol Pharmacol 1990 May; 37(5)631-8.
Score: 0.595
The alpha subunit of the GTP binding protein Gk opens atrial potassium channels.
J Codina ... L Birnbaumer
Science 1987 Apr; 236(4800)442-5.
Score: 0.594
Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.
K Okaichi ... R A Firtel
Mol Biol Cell 1992 Jul; 3(7)735-47.
Score: 0.594
Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.
R T Premont ... R Iyengar
Proc Natl Acad Sci U S A 1992 Oct; 89(20)9809-13.
Score: 0.593
Gbetagamma activation site in adenylyl cyclase type II. Adenylyl cyclase type III is inhibited by Gbetagamma.
Susanne Diel ... Christiane Kleuss
J Biol Chem 2006 Jan; 281(1)288-94.
Score: 0.593
Regulation of signal transfer from beta 1-adrenoceptor to adenylate cyclase by beta gamma subunits in a reconstituted system.
M Hekman ... E J Helmreich
Eur J Biochem 1987 Dec; 169(2)431-9.
Score: 0.593
Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase.
Y Kanaho ... M Vaughan
J Biol Chem 1984 Jun; 259(12)7378-81.
Score: 0.593
G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions.
S Osawa ... G L Johnson
Cell 1990 Nov; 63(4)697-706.
Score: 0.593
Nobel Lecture. G proteins and regulation of adenylyl cyclase.
A G Gilman
Biosci Rep 1995 Apr; 15(2)65-97.
Score: 0.592
Genetic and structural analysis of G protein alpha subunit regulatory domains.
G L Johnson ... A E Ruoho
J Cell Biochem 1991 Oct; 47(2)136-46.
Score: 0.591
Characteristics of the alpha 2/beta 2-adrenergic receptor-coupled adenylyl cyclase system in rat myometrium during pregnancy.
S Mhaouty ... C Legrand
J Biol Chem 1995 May; 270(18)11012-6.
Score: 0.591
Truncation and alanine-scanning mutants of type I adenylyl cyclase.
W J Tang ... A G Gilman
Biochemistry 1995 Nov; 34(44)14563-72.
Score: 0.590
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
G D Kim ... G Milligan
Eur J Biochem 1994 Jan; 219(1-2)135-43.
Score: 0.589
Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation.
Mousumi Ghosh ... Alan V Smrcka
J Biol Chem 2003 Sep; 278(37)34747-50.
Score: 0.589
Structure of the adenylyl cyclase catalytic core.
G Zhang ... J H Hurley
Nature 1997 Mar; 386(6622)247-53.
Score: 0.589
Mediation by G protein betagamma subunits of the opioid stimulation of adenylyl cyclase activity in rat olfactory bulb.
M C Olianas ... P Onali
Biochem Pharmacol 1999 Mar; 57(6)649-52.
Score: 0.589
Role of G protein betagamma subunits in muscarinic receptor-induced stimulation and inhibition of adenylyl cyclase activity in rat olfactory bulb.
M C Olianas ... P Onali
J Neurochem 1998 Jun; 70(6)2620-7.
Score: 0.589
Isoform-targeted regulation of cardiac adenylyl cyclase.
Yoshihiro Ishikawa
J Cardiovasc Pharmacol 2003 Jan; 41 Suppl 1()S1-4.
Score: 0.589
Effect of endurance physical training on rat liver adenylyl cyclase system.
J L Nieto ... A Haro
Cell Signal 1996 Jun; 8(4)317-22.
Score: 0.589
Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.
M K Ho ... Y H Wong
J Neurochem 1997 Jun; 68(6)2514-22.
Score: 0.589
Involvement of the beta gamma subunits of inhibitory GTP-binding protein in chemoattractant receptor-mediated potentiation of cyclic AMP formation in guinea pig neutrophils.
T Suzuki ... T Katada
Biochim Biophys Acta 1996 Aug; 1313(1)72-8.
Score: 0.588
Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells.
M M Cripps ... D J Bennett
Life Sci 1992 ; 50(5)PL19-24.
Score: 0.588
Quantitative changes in G proteins do not mediate ethanol-induced downregulation of adenylyl cyclase in mouse cerebral cortex.
B Tabakoff ... P L Hoffman
Alcohol Clin Exp Res 1995 Feb; 19(1)187-94.
Score: 0.587
Functional domains of delta- and mu-opioid receptors responsible for adenylyl cyclase inhibition.
G Megaritis ... Z Georgoussi
Receptors Channels 2000 ; 7(3)199-212.
Score: 0.587
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.
T Higashijima ... A G Gilman
J Biol Chem 1987 Jan; 262(2)762-6.
Score: 0.587
Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin.
E J Choi ... D R Storm
Biochemistry 1992 Jul; 31(28)6492-8.
Score: 0.586
The SH3 domain of the S. cerevisiae Cdc25p binds adenylyl cyclase and facilitates Ras regulation of cAMP signalling.
K A Mintzer ... J Field
Cell Signal 1999 Feb; 11(2)127-35.
Score: 0.586
Allosteric determinants in guanine nucleotide-binding proteins.
Mark E Hatley ... Rama Ranganathan
Proc Natl Acad Sci U S A 2003 Nov; 100(24)14445-50.
Score: 0.586
Differential regulation of ANF-R2 receptors coupled to adenylyl cyclase in cardiovascular tissues in hypertension.
M B Anand-Srivastava
Am J Hypertens 1993 Jun; 6(6 Pt 1)538-41.
Score: 0.585
Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma.
T Kozasa ... A G Gilman
J Biol Chem 1996 May; 271(21)12562-7.
Score: 0.584
Immunological relatedness between Bordetella pertussis and rat brain adenylyl cyclases.
A Monneron ... A Ullmann
Biochemistry 1988 Jan; 27(2)536-9.
Score: 0.584
Guanylyl cyclases, a growing family of signal-transducing enzymes.
D Koesling ... G Schultz
FASEB J 1991 Oct; 5(13)2785-91.
Score: 0.584
Facilitation of signal onset and termination by adenylyl cyclase.
K Scholich ... T B Patel
Science 1999 Feb; 283(5406)1328-31.
Score: 0.584
Beta-adrenergic signal transduction in the failing and hypertrophied myocardium.
M Böhm ... P Schnabel
J Mol Med 1997 Nov-Dec; 75(11-12)842-8.
Score: 0.583
Developmental expression of G proteins that differentially modulate adenylyl cyclase activity in mouse brain.
R A Rius ... W A Klee
FEBS Lett 1991 Aug; 288(1-2)51-4.
Score: 0.582
Receptor activation of G proteins.
E R Weiss ... G L Johnson
FASEB J 1988 Oct; 2(13)2841-8.
Score: 0.580
Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.
J Codina ... R D Sekura
J Biol Chem 1984 Sep; 259(18)11408-18.
Score: 0.580
A functional chimera of mammalian guanylyl and adenylyl cyclases.
S Weitmann ... C Kleuss
Biochemistry 1999 Mar; 38(11)3409-13.
Score: 0.580
Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.
T Katada ... M Ui
J Biol Chem 1986 Apr; 261(11)5215-21.
Score: 0.580
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma.
J A Iñiguez-Lluhi ... A G Gilman
J Biol Chem 1992 Nov; 267(32)23409-17.
Score: 0.580
A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes.
N F Lim ... H A Lester
J Gen Physiol 1995 Mar; 105(3)421-39.
Score: 0.579
RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III.
S Sinnarajah ... J H Kehrl
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G protein diversity is increased by associations with a variety of gamma subunits.
N Gautam ... M I Simon
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Human-Xenopus chimeras of Gs alpha reveal a new region important for its activation of adenylyl cyclase.
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Cross-regulation between G-protein-mediated pathways. Stimulation of adenylyl cyclase increases expression of the inhibitory G-protein, Gi alpha 2.
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J Biol Chem 1990 Sep; 265(25)14784-90.
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Adenylyl cyclase in lung from hypersensitive guinea pig displays increased responsiveness to guanine nucleotides and isoprenaline: the role of the G proteins Gs and Gi.
M Grady ... N Pyne
Biochim Biophys Acta 1993 Apr; 1176(3)313-20.
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Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors.
R C Tsu ... Y H Wong
Mol Pharmacol 1995 Apr; 47(4)835-41.
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Muscarinic receptor-mediated inhibition of GDP-activated adenylyl cyclase suggests a direct interaction of inhibitory guanine nucleotide-binding proteins and adenylyl cyclase.
F Niroomand ... B Rauch
Mol Pharmacol 1993 Jan; 43(1)90-5.
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The presence of free G protein beta/gamma subunits in human neutrophils results in suppression of adenylate cyclase activity.
G M Bokoch
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Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.
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J Biol Chem 1990 Jan; 265(1)63-9.
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Interaction between G-protein beta and gamma subunit types is selective.
A N Pronin ... N Gautam
Proc Natl Acad Sci U S A 1992 Jul; 89(13)6220-4.
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Effects of agonist exposure on the coupling of beta 1 and beta 3 adrenergic receptors to adenylyl cyclase in isolated adipocytes.
J G Granneman
J Pharmacol Exp Ther 1992 May; 261(2)638-42.
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Inhibitory GTP-binding regulatory protein Gi3 can couple angiotensin II receptors to inhibition of adenylyl cyclase in hepatocytes.
B F Pobiner ... J C Garrison
Mol Pharmacol 1991 Aug; 40(2)156-67.
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Benzyloxybenzaldehyde analogues as novel adenylyl cyclase activators.
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J M Stadel ... S T Crooke
J Recept Res 1994 Dec; 14(6-8)357-79.
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The amino terminus of G protein alpha subunits is required for interaction with beta gamma.
E J Neer ... L G Wolf
J Biol Chem 1988 Jun; 263(18)8996-70.
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Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.
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Mol Endocrinol 1996 Dec; 10(12)1708-18.
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Mol Psychiatry 1996 Dec; 1(6)470-7.
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Mol Biochem Parasitol 1999 Nov; 104(2)205-17.
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J Cardiovasc Pharmacol 1994 Feb; 23(2)188-93.
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Transmembrane signaling, G proteins, and adenylyl cyclase.
A G Gilman
Harvey Lect 1989-1990; 85()153-72.
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J Biol Chem 1998 Jun; 273(26)16332-8.
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Proc Natl Acad Sci U S A 1985 Feb; 82(3)727-31.
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Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.
J D Hildebrandt ... M W Bitensky
J Biol Chem 1985 Nov; 260(27)14867-72.
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J Hypertens 2000 Aug; 18(8)1081-90.
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J Biol Chem 2000 Apr; 275(15)11235-40.
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Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation.
Y H Wong ... H R Bourne
Nature 1991 May; 351(6321)63-5.
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Receptor-induced beta gamma release from fatty acylation-deficient mutants of G alpha z.
H I Beck ... Y H Wong
Neuroreport 1997 Mar; 8(4)937-40.
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The signal transduction between beta-receptors and adenylyl cyclase.
A Levitzki ... A Bar-Sinai
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Biochem Pharmacol 1997 Jul; 54(1)43-59.
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Subcellular distribution of adenylyl cyclase and Gs alpha in rat brown adipose tissue.
A Chaudhry ... J G Granneman
Metabolism 1991 Apr; 40(4)432-7.
Score: 0.567
Gsalpha contains an unidentified covalent modification that increases its affinity for adenylyl cyclase.
C Kleuss ... A G Gilman
Proc Natl Acad Sci U S A 1997 Jun; 94(12)6116-20.
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Cell Signal 1994 Aug; 6(6)681-94.
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Effects of the C-terminal peptide of the alphaS subunit of the G protein on the regulation of adenylyl cyclase and protein kinase A activities by biogenic amines and glucagon in mollusk and rat muscles.
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Neurosci Behav Physiol 2005 Feb; 35(2)177-86.
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Proc Natl Acad Sci U S A 1996 Jun; 93(13)6621-5.
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J Neurochem 2001 Jan; 76(1)182-90.
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L A Mangels ... M E Gnegy
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S C Tsai ... J Moss
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J Neurochem 1995 Feb; 64(2)724-32.
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Hormone signalling via G-protein: regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by Gq.
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Mol Pharmacol 1997 Sep; 52(3)508-14.
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J Clin Invest 1996 Feb; 97(4)949-56.
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Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
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