FRISC > Faculty Profiles > Elizabeth J. Goldsmith, Ph.D.

FRISC: The Faculty Research Interests Science Comparator

Elizabeth J. Goldsmith, Ph.D.
Professor of Biochemistry
Biological Chemistry
Molecular Biophysics
Office: (214) 648-5009
FAX: (214) 648-8954
Email: betsy@chop.swmed.edu
Home Page: Goldsmith Lab

New This Month | New This Year | Abstract | Selected Publications | FRISC Statistics Results - FULL MEDLINE:

	The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. K P Wilson ... M S Su Chem Biol 1997 Jun; 4(6)423-31.	Score: 0.500
	p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Sanjay Kumar ... John C Lee Nat Rev Drug Discov 2003 Sep; 2(9)717-26.	Score: 0.451
	Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. H Enslen ... R J Davis J Biol Chem 1998 Jan; 273(3)1741-8.	Score: 0.451
	Inhibition of p38 MAP kinase as a therapeutic strategy. J C Lee ... J L Adams Immunopharmacology 2000 May; 47(2-3)185-201.	Score: 0.448
	Serpins and other covalent protease inhibitors. S Ye ... E J Goldsmith Curr Opin Struct Biol 2001 Dec; 11(6)740-5.	Score: 0.448
	The serpins: nature's molecular mousetraps. J A Huntington ... R W Carrell Sci Prog 2001 ; 84(Pt 2)125-36.	Score: 0.445
	Structural basis of latency in plasminogen activator inhibitor-1. J Mottonen ... E J Goldsmith Nature 1992 Jan; 355(6357)270-3.	Score: 0.441
	Phosphorylation of MAP kinases by MAP/ERK involves multiple regions of MAP kinases. J L Wilsbacher ... M H Cobb J Biol Chem 1999 Jun; 274(24)16988-94.	Score: 0.435
	The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Z Wang ... E J Goldsmith Proc Natl Acad Sci U S A 1997 Mar; 94(6)2327-32.	Score: 0.429
	The length of the reactive center loop modulates the latency transition of plasminogen activator inhibitor-1. Yu-Ran Na ... Hana Im Protein Sci 2005 Jan; 14(1)55-63.	Score: 0.428
	The role of conformational change in serpin structure and function. P Gettins ... M Schapira Bioessays 1993 Jul; 15(7)461-7.	Score: 0.426
	Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches. A J Whitmarsh ... R J Davis Sci STKE 1999 Sep; 1999(1)PE1.	Score: 0.426
	Competitive inhibition of MAP kinase activation by a peptide representing the alpha C helix of ERK. K Y Horiuchi ... R A Copeland Biochemistry 1998 Jun; 37(25)8879-85.	Score: 0.424
	Structural basis of inhibitor selectivity in MAP kinases. Z Wang ... E J Goldsmith Structure 1998 Sep; 6(9)1117-28.	Score: 0.422
	Conformational diversity of catalytic cores of protein kinases. J M Sowadski ... R Karlsson Pharmacol Ther 1999 May-Jun; 82(2-3)157-64.	Score: 0.421
	Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. G Pearson ... M H Cobb Endocr Rev 2001 Apr; 22(2)153-83.	Score: 0.421
	Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1. K Aertgeerts ... P J Declerck Nat Struct Biol 1995 Oct; 2(10)891-7.	Score: 0.418
	Structural basis for selective inhibition of Src family kinases by PP1. Y Liu ... K M Shokat Chem Biol 1999 Sep; 6(9)671-8.	Score: 0.417
	Inhibitors of serine/threonine kinases. J C Lee ... J L Adams Curr Opin Biotechnol 1995 Dec; 6(6)657-61.	Score: 0.414
	Serpins: finely balanced conformational traps. Robert N Pike ... James C Whisstock IUBMB Life 2002 Jul; 54(1)1-7.	Score: 0.410
	Mitogen-activated protein kinase signaling. Svetlana V Kyosseva Int Rev Neurobiol 2004 ; 59()201-20.	Score: 0.409
	Molecular basis for p38 protein kinase inhibitor specificity. J Lisnock ... P LoGrasso Biochemistry 1998 Nov; 37(47)16573-81.	Score: 0.408
	Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases. Thomas Kietzmann ... Agnes Görlach Thromb Haemost 2003 Apr; 89(4)666-73.	Score: 0.405
	Production, characterization, and use of serpin antibodies. J Alain Kummer ... C Erik Hack Methods 2004 Feb; 32(2)141-9.	Score: 0.404
	Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide. Y Xue ... J Deinum Structure 1998 May; 6(5)627-36.	Score: 0.403
	Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3. Sijiu Liu ... Zhong-Yin Zhang Proc Natl Acad Sci U S A 2006 Apr; 103(14)5326-31.	Score: 0.403
	Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. Anja P Einholm ... Peter A Andreasen Biochem J 2003 Aug; 373(Pt 3)723-32.	Score: 0.401
	Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. B Dérijard ... R J Davis Science 1995 Feb; 267(5198)682-5.	Score: 0.401
	Identification of a conformationally distinct form of plasminogen activator inhibitor-1, acting as a noninhibitory substrate for tissue-type plasminogen activator. P J Declerck ... D Collen J Biol Chem 1992 Jun; 267(17)11693-6.	Score: 0.401
	A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. L Tong ... C A Pargellis Nat Struct Biol 1997 Apr; 4(4)311-6.	Score: 0.398
	Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns. D J Loskutoff ... H Pannekoek Biochemistry 1987 Jun; 26(13)3763-8.	Score: 0.397
	The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition. Kate F Fulton ... James C Whisstock J Biol Chem 2005 Mar; 280(9)8435-42.	Score: 0.396
	The growing family of MAP kinases: regulation and specificity. M Kortenjann ... P E Shaw Crit Rev Oncog 1995 ; 6(2)99-115.	Score: 0.396
	Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. A J Whitmarsh ... R J Davis J Mol Med 1996 Oct; 74(10)589-607.	Score: 0.395
	MAP kinases and vascular smooth muscle function. E Takahashi ... B C Berk Acta Physiol Scand 1998 Dec; 164(4)611-21.	Score: 0.394
	Crystal structure of ovalbumin as a model for the reactive centre of serpins. P E Stein ... R W Carrell Nature 1990 Sep; 347(6288)99-102.	Score: 0.393
	The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses. M Rincón ... R A Davis Free Radic Biol Med 2000 May; 28(9)1328-37.	Score: 0.392
	MAP kinases: universal multi-purpose signaling tools. C Jonak ... H Hirt Plant Mol Biol 1994 Feb; 24(3)407-16.	Score: 0.391
	The structure of active serpin 1K from Manduca sexta. J Li ... E J Goldsmith Structure 1999 Jan; 7(1)103-9.	Score: 0.390
	How serpins change their fold for better and for worse. Robin W Carrell ... James A Huntington Biochem Soc Symp 2003 ; (70)163-78.	Score: 0.389
	Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. M Wysk ... R J Davis Proc Natl Acad Sci U S A 1999 Mar; 96(7)3763-8.	Score: 0.388
	Plasminogen activator inhibitors: hormonally regulated serpins. P A Andreasen ... S N Stacey Mol Cell Endocrinol 1990 Jan; 68(1)1-19.	Score: 0.388
	The p38 MAP kinase pathway and its biological function. L New ... J Han Trends Cardiovasc Med 1998 Jul; 8(5)220-8.	Score: 0.387
	Physiological functions of protein kinase inhibitors. J J Turchi ... M Ho EXS 2000 ; 89()109-21.	Score: 0.386
	Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia. Fatih M Uckun ... Chen Mao Curr Pharm Des 2004 ; 10(10)1083-91.	Score: 0.385
	Modulation of protein kinase signaling by protein phosphatases and inhibitors. Zhong-Yin Zhang ... Laiping Xie Pharmacol Ther 2002 Feb-Mar; 93(2-3)307-17.	Score: 0.385
	The dynamics of cyclin dependent kinase structure. D O Morgan Curr Opin Cell Biol 1996 Dec; 8(6)767-72.	Score: 0.385
	MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. C J Marshall Curr Opin Genet Dev 1994 Feb; 4(1)82-9.	Score: 0.384
	Acquisition of inhibitor-sensitive protein kinases through protein design. A C Bishop ... K M Shokat Pharmacol Ther 1999 May-Jun; 82(2-3)337-46.	Score: 0.384
	MAP kinase pathways. M H Cobb Prog Biophys Mol Biol 1999 ; 71(3-4)479-500.	Score: 0.382
	Molecular evolution of plasminogen activator inhibitor-1 functional stability. M B Berkenpas ... D Ginsburg EMBO J 1995 Jul; 14(13)2969-77.	Score: 0.381
	Structure-activity relationships of p38 mitogen-activated protein kinase inhibitors. Jordi Bolós Mini Rev Med Chem 2005 Sep; 5(9)857-68.	Score: 0.381
	Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential. L Prade ... D Bossemeyer Structure 1997 Dec; 5(12)1627-37.	Score: 0.380
	MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. J Raingeaud ... R J Davis Mol Cell Biol 1996 Mar; 16(3)1247-55.	Score: 0.379
	Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase. M W Kieran ... B J Mayer Oncogene 1999 Nov; 18(48)6647-57.	Score: 0.379
	Kinase selectivity profiling by inhibitor affinity chromatography. Barbara Valsasina ... Antonella Isacchi Expert Rev Proteomics 2004 Oct; 1(3)303-15.	Score: 0.378
	The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases. P M Fischer Curr Med Chem 2004 Jun; 11(12)1563-83.	Score: 0.377
	Distortion of the active site of chymotrypsin complexed with a serpin. M I Plotnick ... H Rubin Biochemistry 1996 Jun; 35(23)7586-90.	Score: 0.377
	Structural aspects of protein kinase control-role of conformational flexibility. Richard A Engh ... Dirk Bossemeyer Pharmacol Ther 2002 Feb-Mar; 93(2-3)99-111.	Score: 0.376
	Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. A Khokhlatchev ... M H Cobb J Biol Chem 1997 Apr; 272(17)11057-62.	Score: 0.376
	Elk-1 proteins are phosphoproteins and activators of mitogen-activated protein kinase. V N Rao ... E S Reddy Cancer Res 1993 Aug; 53(15)3449-54.	Score: 0.375
	Inhibitors of p38 MAP kinase: therapeutic intervention in cytokine-mediated diseases. F G Salituro ... M S Su Curr Med Chem 1999 Sep; 6(9)807-23.	Score: 0.374
	Coupling of M(2) muscarinic receptors to ERK MAP kinases and caldesmon phosphorylation in colonic smooth muscle. A K Cook ... W T Gerthoffer Am J Physiol Gastrointest Liver Physiol 2000 Mar; 278(3)G429-37.	Score: 0.374
	Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. F Zhang ... E J Goldsmith Nature 1994 Feb; 367(6465)704-11.	Score: 0.374
	The organization of the human-plasminogen-activator-inhibitor-1 gene. Implications on the evolution of the serine-protease inhibitor family. L Strandberg ... T Ny Eur J Biochem 1988 Oct; 176(3)609-16.	Score: 0.374
	Strategies for the design of potent and selective kinase inhibitors. Campbell McInnes ... Peter M Fischer Curr Pharm Des 2005 ; 11(14)1845-63.	Score: 0.374
	Identification and characterization of a nerve growth factor-stimulated mitogen-activated protein kinase activator in PC12 cells. R K Jaiswal ... G E Landreth J Biol Chem 1993 Apr; 268(10)7055-63.	Score: 0.372
	Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. J A Frost ... M H Cobb Mol Cell Biol 1996 Jul; 16(7)3707-13.	Score: 0.372
	MAP kinase phosphatases. Aspasia Theodosiou ... Alan Ashworth Genome Biol 2002 Jun; 3(7)REVIEWS3009.	Score: 0.372
	Map kinase signaling pathways and hematologic malignancies. Leonidas C Platanias Blood 2003 Jun; 101(12)4667-79.	Score: 0.371
	Protein kinase signaling in the modulation of microvascular permeability. Sarah Y Yuan Vascul Pharmacol 2002 Nov; 39(4-5)213-23.	Score: 0.370
	Rational design of complex formation between plasminogen activator inhibitor-1 and its target proteinases. K Aertgeerts ... P J Declerck J Struct Biol 1997 Apr; 118(3)236-42.	Score: 0.370
	Regulation of the MAP kinase cascade. M H Cobb ... D J Robbins Cell Mol Biol Res 1994 ; 40(3)253-6.	Score: 0.369
	Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. Jason T Yustein ... Hsing-Jien Kung Oncogene 2003 Sep; 22(40)6129-41.	Score: 0.369
	Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation. H Kosako ... E Nishida EMBO J 1992 Aug; 11(8)2903-8.	Score: 0.368
	Interactions causing the kinetic trap in serpin protein folding. Hana Im ... Myeong-Hee Yu J Biol Chem 2002 Nov; 277(48)46347-54.	Score: 0.368
	Plasminogen activator inhibitors--a review. E K Kruithof Enzyme 1988 ; 40(2-3)113-21.	Score: 0.368
	Structural insights into AGC kinase inhibition. Christine Breitenlechner ... Dirk Bossemeyer Oncol Res 2004 ; 14(6)267-78.	Score: 0.368
	Distortion of the catalytic domain of tissue-type plasminogen activator by plasminogen activator inhibitor-1 coincides with the formation of stable serpin-proteinase complexes. Michel J Perron ... Joseph D Shore J Biol Chem 2003 Nov; 278(48)48197-203.	Score: 0.367
	The MAP kinase cascade is essential for diverse signal transduction pathways. E Nishida ... Y Gotoh Trends Biochem Sci 1993 Apr; 18(4)128-31.	Score: 0.367
	Recent kinase and kinase inhibitor X-ray structures: mechanisms of inhibition and selectivity insights. M Cherry ... D H Williams Curr Med Chem 2004 Mar; 11(6)663-73.	Score: 0.367
	Epitope mapping for four monoclonal antibodies against human plasminogen activator inhibitor type-1: implications for antibody-mediated PAI-1-neutralization and vitronectin-binding. T Wind ... P A Andreasen Eur J Biochem 2001 Feb; 268(4)1095-106.	Score: 0.367
	Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). Y Jiang ... J Han J Biol Chem 1996 Jul; 271(30)17920-6.	Score: 0.366
	Regulation of mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle cells. D Bokemeyer ... H J Kramer Hypertension 1998 Oct; 32(4)661-7.	Score: 0.366
	Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity. Catherine E Fitzgerald ... Giovanna Scapin Nat Struct Biol 2003 Sep; 10(9)764-9.	Score: 0.366
	The p38 mitogen-activated protein kinase pathway in interferon signal transduction. Efstratios Katsoulidis ... Leonidas C Platanias J Interferon Cytokine Res 2005 Dec; 25(12)749-56.	Score: 0.366
	Protein phosphatases and the regulation of MAP kinase activity. S M Keyse Semin Cell Dev Biol 1998 Apr; 9(2)143-52.	Score: 0.366
	Structure of a serpin-protease complex shows inhibition by deformation. J A Huntington ... R W Carrell Nature 2000 Oct; 407(6806)923-6.	Score: 0.365
	elk-1 proteins interact with MAP kinases. V N Rao ... E S Reddy Oncogene 1994 Jul; 9(7)1855-60.	Score: 0.365
	Protein kinase cascades activated by stress and inflammatory cytokines. J M Kyriakis ... J Avruch Bioessays 1996 Jul; 18(7)567-77.	Score: 0.365
	Insulin activates p38 mitogen-activated protein (MAP) kinase via a MAP kinase kinase (MKK) 3/MKK 6 pathway in vascular smooth muscle cells. M Igarashi ... T Kato Eur J Clin Invest 2000 Aug; 30(8)668-77.	Score: 0.365
	Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J A Nick ... G S Worthen J Immunol 1996 Jun; 156(12)4867-75.	Score: 0.364
	Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. N Narayana ... S S Taylor Biochemistry 1999 Feb; 38(8)2367-76.	Score: 0.364
	Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway. I A Yamboliev ... W T Gerthoffer Am J Physiol Heart Circ Physiol 2000 Jun; 278(6)H1899-907.	Score: 0.364
	Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Christopher Pargellis ... John Regan Nat Struct Biol 2002 Apr; 9(4)268-72.	Score: 0.363
	Serpins 2005 - fun between the beta-sheets. Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia). James C Whisstock ... Paul Coughlin FEBS J 2005 Oct; 272(19)4868-73.	Score: 0.363
	Signaling by dual specificity kinases. N Dhanasekaran ... E Premkumar Reddy Oncogene 1998 Sep; 17(11 Reviews)1447-55.	Score: 0.363
	Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. L A Groom ... S M Keyse EMBO J 1996 Jul; 15(14)3621-32.	Score: 0.362
	HOG on the promoter: regulation of the osmotic stress response. S P Chellappan Sci STKE 2001 Jul; 2001(93)PE1.	Score: 0.362
	The status of plasminogen activator inhibitor-1 as a therapeutic target. P Charlton Expert Opin Investig Drugs 1997 May; 6(5)539-54.	Score: 0.362
	Molecular roles of MAP kinases and FADD phosphorylation in prostate cancer. K Shimada ... N Konishi Histol Histopathol 2006 Apr; 21(4)415-22.	Score: 0.361
	MAP kinase kinase kinases and innate immunity. Antony Symons ... Steven C Ley Trends Immunol 2006 Jan; 27(1)40-8.	Score: 0.360
	Coordinate signaling by Src and p38 kinases in the induction of cortical cataracts. Jian Zhou ... A Sue Menko Invest Ophthalmol Vis Sci 2004 Jul; 45(7)2314-23.	Score: 0.360
	Expression, activity, and regulation of MAP kinases in cultured chondrocytes. Jang-Soo Chun Methods Mol Med 2004 ; 100()291-306.	Score: 0.360
	Plasminogen activator inhibitor-1. Ann Gils ... Paul J Declerck Curr Med Chem 2004 Sep; 11(17)2323-34.	Score: 0.360
	Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. D T Denhardt Biochem J 1996 Sep; 318 ( Pt 3)()729-47.	Score: 0.360
	Mechanisms of glycosaminoglycan activation of the serpins in hemostasis. J A Huntington J Thromb Haemost 2003 Jul; 1(7)1535-49.	Score: 0.359
	A small molecule-kinase interaction map for clinical kinase inhibitors. Miles A Fabian ... David J Lockhart Nat Biotechnol 2005 Mar; 23(3)329-36.	Score: 0.359
	Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. B M Yashar ... L I Zon Mol Cell Biol 1993 Sep; 13(9)5738-48.	Score: 0.359
	The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity. Giovanna Scapin ... Philip V LoGrasso Chem Biol 2003 Aug; 10(8)705-12.	Score: 0.359
	Protein kinases 1988: a current perspective. P J Blackshear ... J F Kuo FASEB J 1988 Nov; 2(14)2957-69.	Score: 0.359
	Mechanism of p38 MAP kinase activation in vivo. Deborah Brancho ... Roger J Davis Genes Dev 2003 Aug; 17(16)1969-78.	Score: 0.358
	Phosphatidylinositol 3-kinases regulate ERK and p38 MAP kinases in canine colonic smooth muscle. I A Yamboliev ... W T Gerthoffer Am J Physiol Cell Physiol 2000 Aug; 279(2)C352-60.	Score: 0.357
	Primary structure of BMK1: a new mammalian map kinase. J D Lee ... J Han Biochem Biophys Res Commun 1995 Aug; 213(2)715-24.	Score: 0.357
	Serpins and other serine protease inhibitors. P A Patston Immunol Today 2000 Jul; 21(7)354.	Score: 0.356
	The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation. S Bellon ... K P Wilson Structure 1999 Sep; 7(9)1057-65.	Score: 0.356
	Protein kinase inhibitors: the tyrosine-specific protein kinases. D S Lawrence ... J Niu Pharmacol Ther 1998 Feb; 77(2)81-114.	Score: 0.355
	Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight. Erika De Moliner ... Roberto Battistutta J Biol Chem 2003 Jan; 278(3)1831-6.	Score: 0.355
	Expression of the ERK-specific MAP kinase phosphatase PYST1/MKP3 in mouse embryos during morphogenesis and early organogenesis. Robin J Dickinson ... Gillian M Morriss-Kay Mech Dev 2002 May; 113(2)193-6.	Score: 0.355
	Magic bullets for protein kinases. A C Bishop ... K M Shokat Trends Cell Biol 2001 Apr; 11(4)167-72.	Score: 0.355
	Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases. C Zhang ... M A Beaven J Biol Chem 1997 May; 272(20)13397-402.	Score: 0.355
	Protein kinase inhibitors--potential chemotherapeutic agents. D Shugar Acta Biochim Pol 1995 ; 42(4)405-18.	Score: 0.355
	Scaffolding and protein interactions in MAP kinase modules. M Karandikar ... M H Cobb Cell Calcium 1999 Nov; 26(5)219-26.	Score: 0.354
	The role of protein phosphatases in the regulation of mitogen and stress-activated protein kinases. S M Keyse Free Radic Res 1999 Oct; 31(4)341-9.	Score: 0.354
	Protein kinases--structure and function. D Bossemeyer FEBS Lett 1995 Aug; 369(1)57-61.	Score: 0.354
	Signal transduction. Switching off MAP kinases. P R Clarke Curr Biol 1994 Jul; 4(7)647-50.	Score: 0.354
	Networking with mitogen-activated protein kinases. S L Pelech ... J S Sanghera Mol Cell Biochem 1993 Nov; 127-128()157-69.	Score: 0.354
	Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. R Janknecht ... T Hunter EMBO J 1997 Apr; 16(7)1620-7.	Score: 0.353
	The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. C M Crews ... R L Erikson Science 1992 Oct; 258(5081)478-80.	Score: 0.352
	Protein kinases and phosphatases as therapeutic targets in cancer. Juan-José Ventura ... Angel R Nebreda Clin Transl Oncol 2006 Mar; 8(3)153-60.	Score: 0.352
	Active mutants of the human p38alpha mitogen-activated protein kinase. Ron Diskin ... Oded Livnah J Biol Chem 2004 Nov; 279(45)47040-9.	Score: 0.351
	Protein structure similarity as guiding principle for combinatorial library design. Marcus A Koch ... Herbert Waldmann Biol Chem 2003 Sep; 384(9)1265-72.	Score: 0.351
	The structure-based design of ATP-site directed protein kinase inhibitors. L M Toledo ... D Elbaum Curr Med Chem 1999 Sep; 6(9)775-805.	Score: 0.351
	Serpin-resistant mutants of human tissue-type plasminogen activator. E L Madison ... J F Sambrook Nature 1989 Jun; 339(6227)721-4.	Score: 0.351
	Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors. X Zhu ... K A Morgenstern Structure 1999 Jun; 7(6)651-61.	Score: 0.350
	A template for the protein kinase family. S S Taylor ... M J Zoller Trends Biochem Sci 1993 Mar; 18(3)84-9.	Score: 0.349
	Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway. I N Foltz ... J W Schrader J Biol Chem 1997 Feb; 272(6)3296-301.	Score: 0.349
	MAP kinase regulation--the oncogene connection. S J Leevers ... C J Marshall Trends Cell Biol 1992 Oct; 2(10)283-6.	Score: 0.349
	JNK and p38 MAP kinases in CD4+ and CD8+ T cells. Mercedes Rincón ... Gustavo Pedraza-Alva Immunol Rev 2003 Apr; 192()131-42.	Score: 0.348
	The absence of activator protein 1-dependent gene expression in THP-1 macrophages stimulated with phorbol esters is due to lack of p38 mitogen-activated protein kinase activation. A B Carter ... G W Hunninghake J Biol Chem 2001 Sep; 276(36)33826-32.	Score: 0.348
	MAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction. Sahoko Hirano ... Robert R Gilmont J Surg Res 2002 Feb; 102(2)77-84.	Score: 0.348
	The role of proofreading in signal transduction specificity. Peter S Swain ... Eric D Siggia Biophys J 2002 Jun; 82(6)2928-33.	Score: 0.348
	Molecular cloning of human p38 MAP kinase. J Han ... R J Ulevitch Biochim Biophys Acta 1995 Mar; 1265(2-3)224-7.	Score: 0.348
	The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity. J G Bode ... L Graeve J Biol Chem 1999 Oct; 274(42)30222-7.	Score: 0.347
	Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. M Mohammadi ... J Schlessinger Science 1997 May; 276(5314)955-60.	Score: 0.347
	Protein kinase inhibitors from the urea class. Jacques Dumas Curr Opin Drug Discov Devel 2002 Sep; 5(5)718-27.	Score: 0.347
	MAP kinases bite back. P M Pryciak Dev Cell 2001 Oct; 1(4)449-51.	Score: 0.346
	Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere. L Tong ... P C Anderson Structure 1995 Jan; 3(1)33-40.	Score: 0.346
	Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. S H Yang ... A D Sharrocks Mol Cell Biol 1999 Jun; 19(6)4028-38.	Score: 0.346
	NMR structure of phospho-tyrosine signaling complexes. C B Post ... M L Schneider Med Res Rev 1999 Jul; 19(4)295-305.	Score: 0.346
	Neutralization of plasminogen activator inhibitor-1 inhibitory properties: identification of two different mechanisms. S Debrock ... P J Declerck Biochim Biophys Acta 1997 Feb; 1337(2)257-66.	Score: 0.346
	p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts. Haruhiko Tokuda ... Osamu Kozawa Am J Physiol Endocrinol Metab 2003 Jun; 284(6)E1202-9.	Score: 0.346
	Activation of ERK and p38 MAP kinases in human fibroblasts during collagen matrix contraction. D J Lee ... F Grinnell Exp Cell Res 2000 May; 257(1)190-7.	Score: 0.345
	Quantitative methods for the analysis of protein phosphorylation in drug development. D Michael Olive Expert Rev Proteomics 2004 Oct; 1(3)327-41.	Score: 0.345
	Importance of the amino-acid composition of the shutter region of plasminogen activator inhibitor-1 for its transitions to latent and substrate forms. M Hansen ... P A Andreasen Eur J Biochem 2001 Dec; 268(23)6274-83.	Score: 0.345
	Recombinant plasminogen activator inhibitor type 1: a review of structural, functional, and biological aspects. T M Reilly ... A L Racanelli Blood Coagul Fibrinolysis 1994 Feb; 5(1)73-81.	Score: 0.345
	The serpins: evolution and adaptation in a family of protease inhibitors. R W Carrell ... D R Boswell Cold Spring Harb Symp Quant Biol 1987 ; 52()527-35.	Score: 0.345
	Specificity and mechanism of action of some commonly used protein kinase inhibitors. S P Davies ... P Cohen Biochem J 2000 Oct; 351(Pt 1)95-105.	Score: 0.345
	Mapping of the epitope of a monoclonal antibody protecting plasminogen activator inhibitor-1 against inactivating agents. Julie S Bødker ... Peter A Andreasen Eur J Biochem 2003 Apr; 270(8)1672-9.	Score: 0.345
	Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. X Lu ... A Lin J Biol Chem 1997 Oct; 272(40)24751-4.	Score: 0.345
	p38 MAP kinase negatively regulates cyclin D1 expression in airway smooth muscle cells. K Page ... M B Hershenson Am J Physiol Lung Cell Mol Physiol 2001 May; 280(5)L955-64.	Score: 0.345
	Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors. D M Daigle ... G D Wright J Biol Chem 1997 Oct; 272(40)24755-8.	Score: 0.345
	The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function. S J Harrop ... P M Curmi Structure 1999 Jan; 7(1)43-54.	Score: 0.345
	Ste5: a meeting place for MAP kinases and their associates. E A Elion Trends Cell Biol 1995 Aug; 5(8)322-7.	Score: 0.344
	The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines. Chafiq Hamdouchi ... Harold B Brooks Mol Cancer Ther 2004 Jan; 3(1)1-9.	Score: 0.344
	The intracellular serpin family. R Korpula-Mastalerz ... A Dubin Acta Biochim Pol 1996 ; 43(3)419-29.	Score: 0.344
	Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. Albrecht Messerschmidt ... Michael Blaesse J Mol Biol 2005 Sep; 352(4)918-31.	Score: 0.344
	Differential mechanisms of plasminogen activator inhibitor-1 gene activation by transforming growth factor-beta and tumor necrosis factor-alpha in endothelial cells. Y Q Chen ... J Tseng-Crank Thromb Haemost 2001 Dec; 86(6)1563-72.	Score: 0.344
	Serpins: structure, function and molecular evolution. Diana van Gent ... Noor Kalsheker Int J Biochem Cell Biol 2003 Nov; 35(11)1536-47.	Score: 0.343
	The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. M Muda ... S Arkinstall J Biol Chem 1996 Nov; 271(44)27205-8.	Score: 0.343
	MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor. Y Yu ... J D Sato J Cell Physiol 1999 Feb; 178(2)235-46.	Score: 0.343
	Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. B J Canagarajah ... E J Goldsmith Cell 1997 Sep; 90(5)859-69.	Score: 0.343
	Production of active recombinant mitogen-activated protein kinases through transient transfection of 293T cells. Qun Zhao ... Yusen Liu Protein Expr Purif 2006 Apr; 46(2)468-74.	Score: 0.343
	Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. G J Feng ... F Y Liew J Immunol 1999 Dec; 163(12)6403-12.	Score: 0.342
	Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. M Frödin ... S Gammeltoft Mol Cell Endocrinol 1999 May; 151(1-2)65-77.	Score: 0.342
	MAP kinase kinase: a node connecting multiple pathways. G Mordret Biol Cell 1993 ; 79(3)193-207.	Score: 0.342
	Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. P A Eyers ... M Goedert Chem Biol 1998 Jun; 5(6)321-8.	Score: 0.342
	Localization of protein kinases by anchoring proteins: a theme in signal transduction. D Mochly-Rosen Science 1995 Apr; 268(5208)247-51.	Score: 0.342
	A concerted structural transition in the plasminogen activator inhibitor-1 mechanism of inhibition. Grant E Blouse ... Joseph D Shore Biochemistry 2002 Oct; 41(40)11997-2009.	Score: 0.342
	Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Raingeaud ... R J Davis J Biol Chem 1995 Mar; 270(13)7420-6.	Score: 0.342
	AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells? Isabelle Leclerc ... Guy A Rutter Prog Nucleic Acid Res Mol Biol 2002 ; 71()69-90.	Score: 0.341
	Mitogen-activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34cdc2. M Peter ... E A Nigg Eur J Biochem 1992 Apr; 205(1)287-94.	Score: 0.341
	TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. Gang Lu ... Yibin Wang J Biol Chem 2006 Mar; 281(9)6087-95.	Score: 0.341
	Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines. Christopher G Barber ... Valerie A Horne Bioorg Med Chem Lett 2002 Jan; 12(2)181-4.	Score: 0.341
	TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. Zhu Chen ... Melanie H Cobb J Biol Chem 2003 Jun; 278(25)22278-83.	Score: 0.341
	Deciphering the MAP kinase pathway. G L'Allemain Prog Growth Factor Res 1994 ; 5(3)291-334.	Score: 0.340
	PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. Lily Q Dong ... Feng Liu Am J Physiol Endocrinol Metab 2005 Aug; 289(2)E187-96.	Score: 0.340
	Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. Bradley R Kelemen ... Said A Goueli J Biol Chem 2002 Mar; 277(10)8741-8.	Score: 0.340
	Mobile reactive centre of serpins and the control of thrombosis. R W Carrell ... P E Stein Nature 1991 Oct; 353(6344)576-8.	Score: 0.340
	[Screening of protein kinase inhibitors] Yoshimasa Uehara ... Hidesuke Fukazawa Gan To Kagaku Ryoho 2004 Apr; 31(4)491-4.	Score: 0.340
	Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production. Karen L Cooper ... Laurie G Hudson Toxicol Appl Pharmacol 2004 Nov; 200(3)177-85.	Score: 0.340
	The role of structure in kinase-targeted inhibitor design. David J Pratt ... Martin E M Noble Curr Opin Drug Discov Devel 2004 Jul; 7(4)428-36.	Score: 0.339
	Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. R Ben-Levy ... C J Marshall Curr Biol 1998 Sep; 8(19)1049-57.	Score: 0.339
	Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Deborah K Morrison ... Roger J Davis Annu Rev Cell Dev Biol 2003 ; 19()91-118.	Score: 0.339
	Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. W F De Azevedo ... S H Kim Proc Natl Acad Sci U S A 1996 Apr; 93(7)2735-40.	Score: 0.339
	MAP kinases and CDKs: kinetic basis for catalytic activation. John Lew Biochemistry 2003 Feb; 42(4)849-56.	Score: 0.338
	Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons. K A Heidenreich ... J L Kummer J Biol Chem 1996 Apr; 271(17)9891-4.	Score: 0.338
	Serpins: the uncut version. E J Goldsmith ... J Mottonen Structure 1994 Apr; 2(4)241-4.	Score: 0.338
	Serine/threonine protein kinases and apoptosis. T G Cross ... J M Lord Exp Cell Res 2000 Apr; 256(1)34-41.	Score: 0.338
	The biostructural pathology of the serpins: critical function of sheet opening mechanism. R W Carrell ... P E Stein Biol Chem Hoppe Seyler 1996 Jan; 377(1)1-17.	Score: 0.338
	Dual specificity phosphatases: a gene family for control of MAP kinase function. M Camps ... S Arkinstall FASEB J 2000 Jan; 14(1)6-16.	Score: 0.338
	The mitogen-activated protein kinases, ERK1 and ERK2. M H Cobb ... D Robbins Semin Cancer Biol 1994 Aug; 5(4)261-8.	Score: 0.338
	Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. S Keates ... C P Kelly J Immunol 1999 Nov; 163(10)5552-9.	Score: 0.337
	MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation. Qin Wang ... Claire M Doerschuk Am J Physiol Lung Cell Mol Physiol 2005 Feb; 288(2)L359-69.	Score: 0.337
	Crystal structure of aurora-2, an oncogenic serine/threonine kinase. Graham M T Cheetham ... Douglas A Austen J Biol Chem 2002 Nov; 277(45)42419-22.	Score: 0.337
	Crystal structure of JNK3: a kinase implicated in neuronal apoptosis. X Xie ... M S Su Structure 1998 Aug; 6(8)983-91.	Score: 0.337
	Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. B Stein ... M S Barbosa J Biol Chem 1996 May; 271(19)11427-33.	Score: 0.337
	Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. D H Brotherton ... E D Laue Nature 1998 Sep; 395(6699)244-50.	Score: 0.337
	Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27. K Kato ... Y Inaguma Cell Stress Chaperones 2001 Jan; 6(1)16-20.	Score: 0.336
	Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades. M Lopez-Ilasaca Biochem Pharmacol 1998 Aug; 56(3)269-77.	Score: 0.336
	Plasma serine proteinase inhibitors (serpins) exhibit major conformational changes and a large increase in conformational stability upon cleavage at their reactive sites. M Bruch ... J Engel J Biol Chem 1988 Nov; 263(32)16626-30.	Score: 0.336
	Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes. K Hardy ... G Chaudhri Immunol Cell Biol 1997 Dec; 75(6)528-45.	Score: 0.336
	Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo. K M Hsiao ... J E Ferrell Proc Natl Acad Sci U S A 1994 Jun; 91(12)5480-4.	Score: 0.336
	Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. Heshu Lu ... Ursula Schulze-Gahmen J Med Chem 2005 Feb; 48(3)737-43.	Score: 0.336
	Mammalian mitogen-activated protein kinase pathways are regulated through formation of specific kinase-activator complexes. B W Zanke ... J R Woodgett J Biol Chem 1996 Nov; 271(47)29876-81.	Score: 0.336
	Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts. Osamu Kozawa ... Toshihiko Uematsu J Cell Biochem 2002 ; 84(3)583-9.	Score: 0.336
	Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase. Jorg Hamm ... Ricardo M Biondi J Biol Chem 2002 Nov; 277(48)45793-802.	Score: 0.335
	Purification of recombinant plasminogen activator inhibitor-1 in the active conformation by refolding from inclusion bodies. Hak-Joo Lee ... Hana Im Protein Expr Purif 2003 Sep; 31(1)99-107.	Score: 0.335
	The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors. Lei Jin ... Katherine J Seidl J Biol Chem 2004 Oct; 279(41)42818-25.	Score: 0.335
	Involvement of ERK1/2 and p38 MAP kinase in doxorubicin-induced uPA expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells. Masami Niiya ... Mitsune Tanimoto Oncology 2004 ; 67(3-4)310-9.	Score: 0.335
	Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. A J Waskiewicz ... J A Cooper EMBO J 1997 Apr; 16(8)1909-20.	Score: 0.335
	Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K. Tianjun Zhou ... Elizabeth J Goldsmith Structure 2004 Oct; 12(10)1891-900.	Score: 0.335
	The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Z Li ... J Han Biochem Biophys Res Commun 1996 Nov; 228(2)334-40.	Score: 0.335
	Conformational studies on plasminogen activator inhibitor (PAI-1) in active, latent, substrate, and cleaved forms. E Sancho ... N A Booth Biochemistry 1995 Jan; 34(3)1064-9.	Score: 0.334
	The role of mitogen-activated protein kinases in eotaxin-induced cytokine production from bronchial epithelial cells. Chang-Hao Cui ... Junichi Chihara Am J Respir Cell Mol Biol 2002 Sep; 27(3)329-35.	Score: 0.334
	Significance of secondary structure predictions on the reactive center loop region of serpins: a model for the folding of serpins into a metastable state. P A Patston ... P G Gettins FEBS Lett 1996 Mar; 383(1-2)87-92.	Score: 0.334
	A model of the reactive form of plasminogen activator inhibitor-1. K Aertgeerts ... P J Declerck J Struct Biol 1994 Nov-Dec; 113(3)239-45.	Score: 0.334
	Regulation of corticotropin-releasing factor receptor type 2beta mRNA by mitogen-activated protein kinases in aortic smooth muscle cells. Kazunori Kageyama ... Toshihiro Suda Regul Pept 2005 Mar; 126(3)223-31.	Score: 0.334
	Sequence-based design of kinase inhibitors applicable for therapeutics and target identification. Masha Y Niv ... Hadas Reuveni J Biol Chem 2004 Jan; 279(2)1242-55.	Score: 0.334
	Activation of mitogen-activated protein (MAP) kinase by a MAP kinase-kinase. P D Adams ... P J Parker J Biol Chem 1992 Jul; 267(19)13135-7.	Score: 0.334
	MAP kinases p38 and JNK are activated by the steroid hormone 1alpha,25(OH)2-vitamin D3 in the C2C12 muscle cell line. Claudia G Buitrago ... Ricardo Boland J Cell Biochem 2006 Mar; 97(4)698-708.	Score: 0.334
	Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1. Yiguo Zhang ... Zigang Dong Carcinogenesis 2004 Jul; 25(7)1165-75.	Score: 0.334
	Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. R Seger ... E G Krebs J Biol Chem 1992 Jul; 267(20)14373-81.	Score: 0.334
	Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation. H Nar ... P J Declerck J Mol Biol 2000 Mar; 297(3)683-95.	Score: 0.333
	Protein inhibitors of serine proteinases. J Otlewski ... W Apostoluk Acta Biochim Pol 1999 ; 46(3)531-65.	Score: 0.333
	Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide. Kun-Hyung Lee ... Minoru Yoshida Biosci Biotechnol Biochem 2006 Jan; 70(1)161-71.	Score: 0.333
	Novel protein kinases and molecular mechanisms of autoinhibition. Graham M T Cheetham Curr Opin Struct Biol 2004 Dec; 14(6)700-5.	Score: 0.333
	p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor. Zhiwei He ... Zigang Dong J Biol Chem 2003 Jul; 278(29)26435-42.	Score: 0.333
	Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Han ... R J Ulevitch J Biol Chem 1996 Feb; 271(6)2886-91.	Score: 0.333
	Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. A J Whitmarsh ... R J Davis Mol Cell Biol 1997 May; 17(5)2360-71.	Score: 0.333
	How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase. S S Taylor ... T Hunter FASEB J 1995 Oct; 9(13)1255-66.	Score: 0.332
	Conformational changes and disease--serpins, prions and Alzheimer's. R W Carrell ... B Gooptu Curr Opin Struct Biol 1998 Dec; 8(6)799-809.	Score: 0.332
	Bound to activate: conformational consequences of cyclin binding to CDK2. E Radzio-Andzelm ... S Taylor Structure 1995 Nov; 3(11)1135-41.	Score: 0.332
	Augmentation of sodium butyrate-induced apoptosis by p38 MAP kinase inhibition in rat liver epithelial cells. Ji-Won Jung ... Yong-Soon Lee Antioxid Redox Signal 2005 Nov-Dec; 7(11-12)1767-72.	Score: 0.332
	Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. N R Bhat ... E L Hogan J Neurosci 1998 Mar; 18(5)1633-41.	Score: 0.332
	Features of selective kinase inhibitors. Zachary A Knight ... Kevan M Shokat Chem Biol 2005 Jun; 12(6)621-37.	Score: 0.332
	A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. J Han ... R J Ulevitch Science 1994 Aug; 265(5173)808-11.	Score: 0.332
	Phosphorylation of protein phosphatase inhibitor-1 by Cdk5. J A Bibb ... P Greengard J Biol Chem 2001 Apr; 276(17)14490-7.	Score: 0.331
	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson ... Razvan Lapadat Science 2002 Dec; 298(5600)1911-2.	Score: 0.331
	The inhibitor reacting with a tumour cell surface protease can be exchanged with plasminogen activator inhibitor (PAI-1). F S Steven ... N A Booth J Enzyme Inhib 1991 ; 4(3)273-9.	Score: 0.331
	Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. H Ichijo ... Y Gotoh Science 1997 Jan; 275(5296)90-4.	Score: 0.330
	Stress-activated protein kinases: activation, regulation and function. A Paul ... R Plevin Cell Signal 1997 Sep; 9(6)403-10.	Score: 0.330
	Cytosolic acidification but not auxin at physiological concentration is an activator of MAP kinases in tobacco cells. G Tena ... J P Renaudin Plant J 1998 Oct; 16(2)173-82.	Score: 0.330
	Extracellular-regulated protein kinase cascades are activated in response to injury in human skeletal muscle. D Aronson ... L J Goodyear Am J Physiol 1998 Aug; 275(2 Pt 1)C555-61.	Score: 0.330
	Transcriptional regulation by MAP kinases. R J Davis Mol Reprod Dev 1995 Dec; 42(4)459-67.	Score: 0.330
	Sequence and structural analysis of kinase ATP pocket residues. Anna Vulpetti ... Roberta Bosotti Farmaco 2004 Oct; 59(10)759-65.	Scor