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FRISC: The Faculty Research Interests Science Comparator |
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Professor of Cell Biology
Cell Regulation
Integrative Biology
Office: (214) 648-2181
Email: frederick.grinnell@utsouthwestern.edu
Research in my laboratory concerns cell motility and proliferation during
wound repair. Fibroblasts in resting tissue are quiescent, sessile cells engaged
in minimal biosynthetic activity. After wounding, these cells become
proliferative and migrate into the wound region where they synthesize and
contract a new connective tissue matrix. Once healing has been completed, the
wound fibroblasts become quiescent and regress through apoptosis. Using
three-dimensional collagen matrices, we have developed an in
vitro model that mimics many of the above features of repair including
matrix contraction. We are using the fibroblast-collagen matrix contraction
model to study (1) cell motility and contractility stimulated by
lysophosphatidic acid, platelet-derived growth factor, and transforming growth
factor beta, and (2) mechanoregulation of cell proliferation, especially in
relation to MAP-kinase signaling pathways.
Grinnell, F., Ho, C.H., Tamariz, E., Lee, D.J., and Skuta, G., "Dendritic fibroblasts in three dimensional collagen matrices" Mol Biol Cell., 14:384-395, 2003 i
Fringer, J. and Grinnell, F., "Fibroblast quiescence in floating collagen matrices: Decrease in serum activation of MEK and RAF but not RAS" J. Biol. Chem., 278:20612-20617, 2003
Abe M, Ho CH, Kamm KE, Grinnell F., "Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction" J. Biol. Chem., 278:47707-47712, 2003
Grinnell, F., "Fibroblast biology in three-dimensional collagen matrices" Trends in Cell Biology, 13:264-269, 2003
Tamariz E, Grinnell F., "Modulation of fibroblast morphology and adhesion during collagen matrix remodeling" Mol. Biol. Cell, 13:3915-3929, 2002
Grinnell, F., "The Scientific Attitude, 2nd Edition" Guilford Publishers, New York, N.Y., 1992
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted keyword count
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Database: Medline abstracts (1967 - Present)
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Sort by: Score
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Show: Top 100 hits
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Results computed on: 6/9/2006