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FRISC: The Faculty Research Interests Science Comparator |
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Professor of Internal Medicine
Biological Chemistry
Office: (214) 648-2890
FAX: (214) 648-4837
Email: grundy01@utsw.swmed.edu
Our research at the Center for Human Nutrition is concerned with the interactions of
nutrition, metabolism, and genetics in the development of various chronic diseases,
particularly cardiovascular disease and diabetes. Investigators in the Center for Human
Nutrition have focused their research on several lipid disorders including high levels of
serum LDL cholesterol (the bad cholesterol), elevated triglycerides, and low HDL (the good
cholesterol). In addition we investigate the causes and metabolic consequences of insulin
resistance, a condition that predisposes both to cardiovascular disease and diabetes.
Insulin resistance appears to be a critical factor in the development of a condition
called the metabolic syndrome in which multiple metabolic risk factors for
cardiovascular disease aggregate in single individuals. Particular interest centers on the
role of adipose tissue in insulin resistance. Disorders of adipose tissue include various
forms of lipodystrophy (a deficiency of adipose tissue) and abnormalities in the
distribution of fat (truncal obesity and gluteofemoral obesity). The genetic basis for
these various causes of insulin resistance is under intense investigation. Also, new
therapeutic agents to prevent or treatment the metabolic consequences of insulin
resistance are being carried out.
In addition, the Center is investigating the potential of various dietary adjuncts for
reducing the risk for coronary heart disease. Among the adjuncts being investigated are
dietary antioxidants (e.g. vitamins E and C), plant stanols, monounsaturated oils, N-3
polyunsaturated fats (e.g. fish oils), and dietary fiber. Particular attention is given to
the mechanisms of action whereby these adjuncts may exert their putative benefit.
Selected Publications:
Grundy SM. (1999) The optimal ratio of fat-to-carbohydrate in the diet. Annu Rev
Nutr 19:325-34.
Cohen JC, Vega GL and Grundy SM (1999) Hepatic lipase: new insights from genetic and
metabolic studies. Cur Opin Lipidol 10:259-67.
Chandalia M, Abate N, Garg A, Stray-Gundersen J and Grundy SM (1999) Relationship
between generalized and upper body obesity to insulin resistance in Asian Indian men. J
Clin Endocrinol 84:2329-35.
Vega GL, Clark LT, Tang A, Marcovina S, Grundy SM and Cohen JCC (1998) Hepatic lipase
activity is lower in African American men than in white American men: effects of 5’
flanking polymorphism in the hepatic lipase gene ( LIPC ). J Lipid Res
39:228-32
Peters JM, Barnes R, Bennett L, Gitomer WM, Bowcock AM and Garg A (1998) Localization
of the gene for familial partial lipodystrophy (Dunnigan variety) to chromosome 1qa21-22. Nature
Genetics 18:292-5.
Nie L, Niu S, Vega GL, Clark LT, Tang A, Grundy SM and Cohen JC (1998) Three
polymorphisms associated with low hepatic lipase activity are common in African Americans.
J Lipid Res 39:1900-03.
Mostaza JM, Vega GL and Grundy SM (1998) Abnormal metabolism of free fatty acids in
hypertriglyceridaemic men: apparent insulin resistance of adipose tissue. J Intern Med
243:265-74.
Tato F, Vega GL and Grundy SM (1997) Determinants of plasma HDL-cholesterol in
hypertriglyceridemic patients. Role of cholesterol-ester transfer protein and lecithin
cholesteryl acyl transferase. Arterioscler Thromb Vasc Biol 17:56-63.
McPherson R, Grundy SM, Guerra R and Cohen JC (1996) Allelic variation in the gene
encoding the cholesteryl ester transfer protein is associated with variation in the plasma
concentrations of cholesteryl ester transfer protein. J Lipid Res 37:1743-48.
Devaraj S, Huet G, Fuller C and Jialal I (1996) A dose response comparison of
RRR-alpha-tocopherol and allrac-alpha-tocopherol on LDL oxidation. Arterioscler Thromb
Vasc Biol
Li DJ, Devaraj S, Fuller C, Bucala R and Jialal I (1996) The effect of alpha-tocopherol
on LDL oxidation and glycation: in-vitro and in-vivo studies. J Lipid Res
37:1978-86.
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Last updated: 17 Nov 2000
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted keyword count
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Database: Medline abstracts (1967 - Present)
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Results computed on: 6/9/2006