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FRISC: The Faculty Research Interests Science Comparator |
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Professor, Center for Immunology
Immunology
Office: 214-648-7330
FAX: 214-648-7331
Email: edward.wakeland@email.swmed.edu
Our laboratory utilizes mouse genetics to delineate the genetic basis for
autoimmune disease pathogenesis. Our primary focus has been on systemic
lupus erythematosus (SLE), a debilitating autoimmune disease initiated via a profound
loss of immunologic tolerance to nuclear antigens. We have used genetic
manipulation of the lupus-prone NZM2410 murine model of SLE to dissect SLE
pathogenesis into a series of discrete stages. We are currently in the
process of identifying the individual susceptibility genes and defining the genetic
pathways responsible for the initiation and progression of systemic autoimmunity
in lupus-prone mouse models of SLE. Additional projects within the
laboratory include genetic dissections of autoimmune diabetes and the analysis
of a variety of polymorphisms in normal immune functions. The use of
microarray technology in combination with genetic fine mapping to identify
polymorphic genes with potent immunologic effects is a major new thrust within
the laboratory.
Selected Publications:
Morel, L., Croker, B.P., Blenman, K.R., Mohan, C., Huang, G., Gilkeson, G.
and Wakeland, E.K. (2000) Genetic reconstitution of systemic lupus erythematosus
immunopathology with poly-congenic murine strains. P.N.A.S., 92,12:
6670-6675.
Wakeland, E.K., Wandstrat, A., Liu, K. and Morel, L. (1999) Genetic
dissection of systemic lupus erythematosis, Current Opinion in Immunology, 11:701-707
Morel, L., Tian, X-H., Croker, B.P. and Wakeland E.K. (1999) Epistatic
modifiers of autoimmunity in a murine model of lupus nephritis.
Immunity, 11:131-139
Mohan, C., Morel, L., Yang, P. Watanabe, H., Croker, B., Gilkeson, G. and
Wakeland, E.K. (1999) Genetic dissection of lupus pathogenesis. A recipe
for nephrophilic autoantibodies. J. Clinical Invest. 103:1685-1695
Mohan, C., Yu, Y., Morel, L., Yang, P. and Wakeland, E.K. (1999) Genetic
dissection of SLE Pathogenesis: Sle3 on murine chromosome 7 impact T cell
activation, differentiation and cell death. J. Immunol.
162:6492-6502
Mohan, C., Alas, E., Morel, L., Yang, P. and Wakeland, E.K. (1998) Genetic
dissection of SLE pathogenesis: Sle1 on murine chromosome 1 leads to a selective
loss of tolerance to H2A/H2B/DNA subnucleosomes. J. Clinical Invest.,
101:1362-1372.
Extraction Method: Expand using Medical Synonyms-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted keyword count
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Database: Medline abstracts (1967 - Present)
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Sort by: Score
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Show: Top 100 hits
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Results computed on: 6/9/2006