RIC > Researcher Profiles

Your browser does not support JavaScript or JavaScript has been disabled. Please upgrade to a newer version of the browser or enable JavaScript. You might still be able to use some of the features but some of the useful features use JavaScript. Thank you!

RIC: Research Interest Comparator

Astier Anne, Ph.D.
Affiliation: University of Edinburgh
Email: aastier@ed.ac.uk
Home Page: not provided
All Results | New This Month | Abstract | Selected Publications | RIC Statistics Results - NEW THIS YEAR:

Abstract:
Multiple sclerosis is a complex autoimmune disease with chronic inflammation of the central nervous system (CNS). new approaches need to be developed in treating this disease. CD46 is a potent costimulatory molecule that induces T cell differentiation toward a regulatory Tr1 phenotype and IL-10 production IL-17 Th1. This regulatory function is altered in MS (5). Furthermore, the two cytoplasmic isoforms of CD46 exhibit antagonist effects on inflammation in a mouse model, and an increased expression of the pro-inflammatory tail was observed in patients with MS (6). Experimental autoimmune encephalomyelitis (EAE) is a murine model of MS.

Keywords extracted from the abstract: [ eliminated words list ]

Count	Word
1.820	altered
1.821	antagonist
1.964	approaches
4.004	autoimmune
7.469	cd46
0.664	cell
1.393	central
1.155	chronic
2.135	cns
1.242	complex
3.141	costimulatory
1.837	cytoplasmic
1.308	developed
1.455	differentiation
1.618	disease
2.975	eae
0.585	effects
2.753	encephalomyelitis
2.094	exhibit
1.303	experimental
0.904	expression
2.465	il-10
3.819	il-17
0.933	increased
1.957	induces
3.622	inflammation
2.082	isoforms
2.375	model
1.865	molecule
1.433	mouse

Count	Word
4.522	ms
1.343	multiple
1.819	murine
1.656	need
1.561	nervous
1.035	observed
0.562	patients
1.682	phenotype
1.815	potent
3.116	pro-inflammatory
1.322	production
3.656	regulatory
2.008	sclerosis
0.953	system
2.311	tail
2.590	th1
4.277	tr1
2.198	treating

RIC Statistics:

Extraction Method: Keyword Count with Lexical Variants Added

Eliminated words list: MedlinePlus List

Weighting Method: Term Frequency * Inverse Document Frequency

Database: Medline Updates from current year

Publication Type: All

Score Calculation Method: Cosine Similarity Method

Sort by: Score

Submission date and time: 4-27-2007, 6:9:23

Computation time: 00:00:04

Last updated: Friday, 27-Apr-2007 06:09:27 CDT