|
RIC: Research Interest Comparator |
Microarray databases: storage and retrieval of microarray data.
|
Score: 0.989 | |
Validation of tissue microarray for the immunohistochemical profiling of melanoma.
|
Score: 0.897 | |
High-density tissue microarray.
|
Score: 0.842 | |
[The significance of the tissue microarray technique]
|
Score: 0.842 | |
From microarray data to results. Workshop on genomic approaches to microarray data analysis.
|
Score: 0.819 | |
Microarray standards at last.
|
Score: 0.812 | |
Living cell microarray.
|
Score: 0.812 | |
Automated evaluation and normalization of immunohistochemistry on tissue microarrays with a DNA microarray scanner.
|
Score: 0.808 | |
The promise of microarray technology in melanoma care.
|
Score: 0.785 | |
Melanoma.
|
Score: 0.768 | |
Identification of P-cadherin in primary melanoma using a tissue microarrayer: prognostic implications in a patient cohort with long-term follow up.
|
Score: 0.759 | |
[How can melanoma be stopped? The prevention of melanoma and early recognition of melanoma precursors]
|
Score: 0.754 | |
Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome.
|
Score: 0.733 | |
Melanoma and lesion simulating melanoma.
|
Score: 0.731 | |
Amelanotic melanoma or poorly differentiated melanoma?
|
Score: 0.731 | |
Experiences from tissue microarray in soft tissue sarcomas.
|
Score: 0.729 | |
Microarray technology for surgeons.
|
Score: 0.726 | |
Spotting a microarray system.
|
Score: 0.726 | |
Microarray foray.
|
Score: 0.726 | |
microArRAY of hope.
|
Score: 0.726 | |
Accelr8 commercializes two new microarray products.
|
Score: 0.726 | |
Protein microarray technology.
|
Score: 0.726 | |
Immunophenotyping leukemia by microarray.
|
Score: 0.726 | |
Optical microarray biosensors.
|
Score: 0.726 | |
Microarray standards adopted.
|
Score: 0.726 | |
Storage and transmission of microarray images.
|
Score: 0.721 | |
Tissue microarray (TMA) applications: implications for molecular medicine.
|
Score: 0.704 | |
DNA microarray analysis of postmortem brain tissue.
|
Score: 0.704 | |
To confirm or not to confirm (microarray data)--that is the question.
|
Score: 0.698 | |
Parallel detection and quantification using nine immunoassays in a protein microarray for drug from serum samples.
|
Score: 0.695 | |
Noncutaneous melanoma. Malignant melanoma of the anorectum.
|
Score: 0.694 | |
Ocular melanoma and cutaneous melanoma.
|
Score: 0.694 | |
Melanoma: Sinclair swine melanoma.
|
Score: 0.694 | |
Malignant melanoma excision margins. Melanoma Study Group.
|
Score: 0.694 | |
Amelanotic melanoma (tapioca melanoma) of the iris.
|
Score: 0.694 | |
Melanoma Self-examination Day: Melanoma Monday, May 1, 1995.
|
Score: 0.694 | |
[After diagnosing melanoma in a patient: evaluation of risks of second melanoma and melanoma in the family]
|
Score: 0.690 | |
[ON THE GROWTH OF ROENTGEN-IRRADIATED MALIGNANT MELANOMA IN TISSUE CULTURE AND IN THE TRANSPLANTATION EXPERIMENT. I. EXPERIMENTS WITH MALIGNANT MELANOMA IN MAN AND ANIMAL MELANOMA AFTER A SINGLE IRRADIATION.]
|
Score: 0.679 | |
Development of a multiplex microarray microsystem.
|
Score: 0.674 | |
Humoral immunity in malignant skin melanoma. Isolation of melanoma specific IgG from melanoma metastases.
|
Score: 0.672 | |
Novel relational database for tissue microarray analysis.
|
Score: 0.672 | |
Tissue microarray study for classification of breast tumours.
|
Score: 0.672 | |
[DNA microarray and its application in andrological research]
|
Score: 0.670 | |
Importing MAGE-ML format microarray data into BioConductor.
|
Score: 0.668 | |
[Study on vasculogenic mimicry in malignant melanoma]
|
Score: 0.667 | |
Application of DNA microarray to toxicological research.
|
Score: 0.665 | |
DNA microarray.
|
Score: 0.663 | |
Commercial aspects of microarray technology.
|
Score: 0.663 | |
Linking microarray data to the literature.
|
Score: 0.663 | |
Database designs for microarray data.
|
Score: 0.663 | |
The future of publishing microarray data.
|
Score: 0.663 | |
Microarray technologies 2003 -- an overview.
|
Score: 0.663 | |
[cDNA microarray and SNP analysis]
|
Score: 0.663 | |
Designing microarray oligonucleotide probes.
|
Score: 0.663 | |
Picture story. A protein microarray.
|
Score: 0.663 | |
A primer on the visualization of microarray data.
|
Score: 0.663 | |
The development of microarray standards.
|
Score: 0.663 | |
The real value of microarray technology.
|
Score: 0.663 | |
Platform technologies for microarray analysis.
|
Score: 0.663 | |
Microarray technology: an array of opportunities.
|
Score: 0.663 | |
Statistical analysis of microarray data.
|
Score: 0.663 | |
Immune and gene therapy for melanoma, and the immunobiology of melanoma.
|
Score: 0.662 | |
Does localized melanoma of the foot have a poorer prognosis than melanoma of the leg?
|
Score: 0.662 | |
Is melanoma curable? Long-term survival in consecutive cases of melanoma.
|
Score: 0.662 | |
Recurrent malignant melanoma 51 years after the diagnosis of ocular melanoma.
|
Score: 0.662 | |
Studies on melanoma. II. Sex and survival in human melanoma.
|
Score: 0.662 | |
[Malignant development of juvenile melanoma (Spitz's melanoma)]
|
Score: 0.662 | |
Microarrays in brain research: the good, the bad and the ugly.
|
Score: 0.660 | |
Genomic investigations of posterior uveal melanoma.
|
Score: 0.658 | |
[Tissue microarrays, or the advent of chips in pathology]
|
Score: 0.650 | |
Tissue microarrays: a new approach for quality control in immunohistochemistry.
|
Score: 0.648 | |
Quality assessment of microarray experiments.
|
Score: 0.648 | |
Tissue microarray construction from bone marrow biopsies.
|
Score: 0.643 | |
Microarray technologies -- an overview. The University of California San Diego Extension, Bioscience, Microarray Technologies -- an overview, March 13-15, 2002.
|
Score: 0.641 | |
nm23 as a prognostic marker in primary cutaneous melanoma: evaluation using tissue microarray in a patient group with long-term follow-up.
|
Score: 0.640 | |
Assessing sources of variability in microarray gene expression data.
|
Score: 0.637 | |
[Differentiation of melanoma cells and melanophages in malignant melanoma in humans]
|
Score: 0.634 | |
Melanoma from unknown primary site and amelanotic melanoma.
|
Score: 0.634 | |
Unilateral multifocal uveal melanoma with occult ring melanoma.
|
Score: 0.634 | |
[JUVENILE MELANOMA OF THE EYELID (SOPHIE SPITZ MELANOMA).]
|
Score: 0.634 | |
[Dubreuilh melanoma(lentigo maligna melanoma)]
|
Score: 0.634 | |
Residual intrascleral melanoma. A concern with lamellar sclerouvectomy for uveal melanoma.
|
Score: 0.634 | |
Melanoma patients consume more polyunsaturated fat than people without melanoma.
|
Score: 0.634 | |
Biochemotherapy for melanoma: rational therapeutics in the search for weapons of melanoma destruction.
|
Score: 0.634 | |
Analysis of microarray experiments for pulmonary fibrosis.
|
Score: 0.633 | |
MAPS: a microarray project system for gene expression experiment information and data validation.
|
Score: 0.632 | |
Tissue microarrays: applications in genomic research.
|
Score: 0.632 | |
Microarray data representation, annotation and storage.
|
Score: 0.630 | |
Genome medicine promised by microarray technology.
|
Score: 0.628 | |
Malignant melanoma.
|
Score: 0.627 | |
Melanoma vaccines.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
The aetiology of melanoma.
|
Score: 0.627 | |
MALIGNANT melanoma.
|
Score: 0.627 | |
Malignant melanoma.
|
Score: 0.627 | |
Levodopa and melanoma.
|
Score: 0.627 | |
Melanoma 2001.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Malignant melanoma.
|
Score: 0.627 | |
Sunburn and melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Malignant melanoma.
|
Score: 0.627 | |
The classification of melanoma.
|
Score: 0.627 | |
Anorectal melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
More on melanoma.
|
Score: 0.627 | |
Detecting melanoma.
|
Score: 0.627 | |
Cutaneous melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
MALIGNANT melanoma.
|
Score: 0.627 | |
Melanoma in Queensland.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Understanding melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Malignant melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Melanoma.
|
Score: 0.627 | |
Melanoma of the iris.
|
Score: 0.627 | |
Protein microarray detection strategies: focus on direct detection technologies.
|
Score: 0.623 | |
Feature-size limitations of microarray technology--a critical review.
|
Score: 0.617 | |
Mixture modelling of gene expression data from microarray experiments.
|
Score: 0.616 | |
Non-Hodgkin's lymphoma in the microarray era.
|
Score: 0.614 | |
Liver library: creating a microarray for hepatotoxicants.
|
Score: 0.614 | |
Microarray to be used as routine clinical screen.
|
Score: 0.614 | |
Microarray analysis of idiopathic pulmonary fibrosis.
|
Score: 0.614 | |
Isolation of polysomal RNA for microarray analysis.
|
Score: 0.614 | |
Replication of a DNA microarray.
|
Score: 0.614 | |
An open letter on microarray data from the MGED Society.
|
Score: 0.614 | |
Unravelling the mystery of microarray data analysis.
|
Score: 0.614 | |
Arabidopsis microarray service facilities.
|
Score: 0.614 | |
[Standardization of microarray experiment data]
|
Score: 0.614 | |
Roles and requirements for a research microarray database.
|
Score: 0.614 | |
Complaints raised over restricted microarray access.
|
Score: 0.614 | |
Microarray analysis: a comparative approach.
|
Score: 0.614 | |
Trends in microarray analysis.
|
Score: 0.614 | |
Project creates repository for microarray datasets.
|
Score: 0.614 | |
Making the most of microarray data.
|
Score: 0.614 | |
New kits on the blot--can we microarray the future of atherosclerosis?
|
Score: 0.614 | |
Shift anticipated in DNA microarray market.
|
Score: 0.614 | |
Liver library. Creating a microarray for hepatotoxicants.
|
Score: 0.614 | |
Comparing microarray data: What technology is needed?
|
Score: 0.614 | |
Microarray CGH.
|
Score: 0.614 | |
Microarray analysis: genome-scale hypothesis scanning.
|
Score: 0.614 | |
[Functional genomic analysis with microarray technology]
|
Score: 0.614 | |
Microarray studies challenge theories of metastasis.
|
Score: 0.614 | |
Generalized rank tests for replicated microarray data.
|
Score: 0.613 | |
Tissue microarray technique in soft tissue sarcoma: immunohistochemical Ki-67 expression in malignant fibrous histiocytoma.
|
Score: 0.612 | |
Immunofluorescent detection of common melanoma membrane antigens by sera of melanoma patients immunized against autologous or allogeneic cultured melanoma cells.
|
Score: 0.612 | |
Tapioca melanoma of the iris arising from a ciliary body melanoma.
|
Score: 0.609 | |
[Histopathological differentiation of pigmented nevi, juvenile melanoma and malignant melanoma.]
|
Score: 0.609 | |
[A case for diagnosis: primary melanoma or metastasis of a melanoma with balloon-like cells]
|
Score: 0.609 | |
Radiosensitivity of melanoma cells in culture: implications for radiotherapy of malignant melanoma.
|
Score: 0.609 | |
International Melanoma Research Congress--Foundation for Melanoma Research. 21-24 June 2003, Philadelphia, PA, USA.
|
Score: 0.609 | |
[Comparison of the structure of primary melanoma with melanoma metastasis]
|
Score: 0.609 | |
Melanoma, melanocytic nevi, and other melanoma risk factors in children.
|
Score: 0.609 | |
Report of two cases. Primary melanoma arising in site of previous melanoma.
|
Score: 0.609 | |
[Present state of the melanoma problem & radiotherapy of malignant melanoma.]
|
Score: 0.609 | |
A case of primary choroidal melanoma in a patient with previous cutaneous melanoma.
|
Score: 0.609 | |
Management of uveal melanoma: a continuing dilemma. Collaborative Ocular Melanoma Study Group.
|
Score: 0.609 | |
Criteria for histopathologic diagnosis of melanoma, including melanoma in situ, in historical perspective.
|
Score: 0.609 | |
Therapy of melanoma with allogeneic melanoma lysates alone or with interferon-alfa.
|
Score: 0.609 | |
Melanoma controversies: clinical significance of nodal micrometastases and the future of melanoma vaccines.
|
Score: 0.609 | |
[Effect of 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone on B-16 melanoma in the mouse and AMel 3 melanoma in the hamster]
|
Score: 0.609 | |
Significance of malignant melanoma antigen (melanoma specific protein) in the urine.
|
Score: 0.609 | |
[Malign melanoma; correlation to pregnancy, childhood, familiar malign melanoma.]
|
Score: 0.609 | |
The familial occurrence of cutaneous melanoma, intraocular melanoma, and the dysplastic nevus syndrome.
|
Score: 0.609 | |
Use of a viral lysate of melanoma cells in patients with metastatic melanoma to lymph nodes.
|
Score: 0.609 | |
The familial occurrence of cutaneous melanoma, intraocular melanoma, and the dysplastic nevus syndrome.
|
Score: 0.609 | |
Validation of tissue microarray technology in breast carcinoma.
|
Score: 0.609 | |
Osteogenic melanoma: stromal metaplasia in association with subungual melanoma.
|
Score: 0.609 | |
[THE CONCEPT AND RESULTS OF THE SURGICAL THERAPY OF MELANOMA (MALIGNANT MELANOMA).]
|
Score: 0.609 | |
Malignant melanoma: classification and staging of malignant melanoma.
|
Score: 0.606 | |
Reliability of tissue microarrays in detecting protein expression and gene amplification in breast cancer.
|
Score: 0.605 | |
Unfolding of microarray data.
|
Score: 0.604 | |
A guide to issues in microarray analysis: application to endometrial biology.
|
Score: 0.604 | |
Reliability of the tissue microarray based FISH for evaluation of the HER-2 oncogene in breast carcinoma.
|
Score: 0.601 | |
Linear models for microarray data analysis: hidden similarities and differences.
|
Score: 0.600 | |
The Longhorn Array Database (LAD): an open-source, MIAME compliant implementation of the Stanford Microarray Database (SMD).
|
Score: 0.599 | |
Gene expression profiling of melanocytic lesions.
|
Score: 0.598 | |
Observations on human melanoma cells in tissue culture.
|
Score: 0.597 | |
The MUSC DNA Microarray Database.
|
Score: 0.597 | |
[Aminopeptidase in melanoma tissue (author's transl)]
|
Score: 0.597 | |
[Melanin synthesis in tissue cultures of melanoma in mice]
|
Score: 0.597 | |
DNA microarrays: their use and misuse.
|
Score: 0.596 | |
Microarray databases: standards and ontologies.
|
Score: 0.595 | |
Evaluation of the tissue microarray technique for immunohistochemical analysis in rectal cancer.
|
Score: 0.594 | |
[Cancer diagnosis using microarray technologies]
|
Score: 0.592 | |
SignalViewer: analyzing microarray images.
|
Score: 0.592 | |
Discovering patterns in microarray data.
|
Score: 0.592 | |
M@CBETH: a microarray classification benchmarking tool.
|
Score: 0.591 | |
Standardization of protocols in cDNA microarray analysis.
|
Score: 0.591 | |
The integration of microarray information in the drug development process.
|
Score: 0.590 | |
Pathology of malignant melanoma.
|
Score: 0.590 | |
Oligonucleotide microarray for HLA-DRB1 genotyping: preparation and clinical evaluation.
|
Score: 0.590 | |
Melanoma metastatic to "lipomata".
|
Score: 0.590 | |
Microarray applications: emerging technologies and perspectives.
|
Score: 0.590 | |
Fatal melanoma transferred in a donated kidney 16 years after melanoma surgery.
|
Score: 0.587 | |
[Differential diagnosis of melanoma of Schwann's sheath of the uvea and melanoma of the uveal stroma.]
|
Score: 0.587 | |
Evanescent-imaging-ellipsometry-based microarray reader.
|
Score: 0.587 | |
An amelanotic melanoma transformed into melanotic melanoma with development of vitiligo.
|
Score: 0.587 | |
Comparison and meta-analysis of microarray data: from the bench to the computer desk.
|
Score: 0.587 | |
Analysis of melanoma cell type in uveal melanoma following treatment failure.
|
Score: 0.587 | |
Studies on melanoma. The effect of pregnancy on survival in human melanoma.
|
Score: 0.587 | |
Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma).
|
Score: 0.587 | |
Metastatic malignant melanoma of ciliary body and choroid from a primary melanoma of skin.
|
Score: 0.587 | |
Cytodiagnosis of pulmonary metastatic malignant melanoma from lentigo maligna melanoma.
|
Score: 0.587 | |
The Jules François Memorial lecture. The collaborative ocular melanoma study and management of choroidal melanoma.
|
Score: 0.587 | |
Malignant melanoma and the Scottish Melanoma Group.
|
Score: 0.587 | |
Risk factors for cutaneous malignant melanoma: the Western Canada Melanoma Study.
|
Score: 0.587 | |
Macular and patch lesions of malignant melanoma: malignant melanoma in situ.
|
Score: 0.585 | |
A conceptual and practical overview of cDNA microarray technology: implications for basic and clinical sciences.
|
Score: 0.585 | |
Microarray data mining using gene ontology.
|
Score: 0.585 | |
DNA microarrays: applicability to renal physiology and disease.
|
Score: 0.584 | |
[Preliminary analysis of gene expression profiles in oral cancer with microarray technique]
|
Score: 0.583 | |
Tissue microarray technology: validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistochemical expression.
|
Score: 0.582 | |
Bioinformatics strategies for translating genome-wide expression analyses into clinically useful cancer markers.
|
Score: 0.581 | |
Toxicogenomics data: the road to acceptance.
|
Score: 0.581 | |
A streptavidin-biotin-based microarray platform for immunoassays.
|
Score: 0.581 | |
Local recurrence of melanoma.
|
Score: 0.581 | |
Effect of tissue selection on melanization of MI hamster melanoma.
|
Score: 0.580 | |
Analysis of gastric cancer with cDNA microarray.
|
Score: 0.580 | |
Identification by cDNA microarray technology of genes modulated by artificial ultraviolet radiation in normal human melanocytes: relation to melanocarcinogenesis.
|
Score: 0.579 | |
[Advances in microbiological diagnosis of infectious diseases]
|
Score: 0.578 | |
Construction of a data dependent analysis (DDA) yeast cDNA microarray experiment for use in toxicogenomics.
|
Score: 0.578 | |
Microarray techniques in pathology: tool or toy?
|
Score: 0.577 | |
Immunotherapy of malignant melanoma.
|
Score: 0.576 | |
The melanocyte and melanoma.
|
Score: 0.576 | |
L2L: a simple tool for discovering the hidden significance in microarray expression data.
|
Score: 0.576 | |
Application of microarray profiling to clinical trials in cancer.
|
Score: 0.574 | |
Microarray data analysis in studies of membrane transporters.
|
Score: 0.574 | |
Lichenoid tissue reaction in malignant melanoma: a potential diagnostic pitfall.
|
Score: 0.574 | |
DNA microarray technology to revolutionise cancer treatment.
|
Score: 0.574 | |
Design issues for cDNA microarray experiments.
|
Score: 0.574 | |
Perspective: microarray technology, seeing more than spots.
|
Score: 0.574 | |
[On the pathology of ocular malignant melanoma (author's transl)]
|
Score: 0.574 | |
Experimental design to make the most of microarray studies.
|
Score: 0.574 | |
The human genome: microarray expression analysis.
|
Score: 0.574 | |
Experimental design of DNA microarray experiments.
|
Score: 0.574 | |
The evolution of custom microarray manufacture.
|
Score: 0.574 | |
Injecting new ideas into microarray printing.
|
Score: 0.574 | |
Introduction to microarray experimentation and analysis.
|
Score: 0.574 | |
Immunohistochemical validation of expression microarray results.
|
Score: 0.574 | |
A guide to microarray experiments--an open letter to the scientific journals.
|
Score: 0.574 | |
Microarray technology: an array of applications that is far from micro.
|
Score: 0.574 | |
Preparing fluorescent probes for microarray studies.
|
Score: 0.574 | |
Validation of microarray image analysis accuracy.
|
Score: 0.574 | |
Copper-thionein in melanoma.
|
Score: 0.574 | |
Representational oligonucleotide microarray analysis (ROMA) in pharmacogenomics.
|
Score: 0.574 | |
[Establishment of a business associated with DNA microarray in Hokkaido]
|
Score: 0.574 | |
Microarray studies provide better genetic understanding.
|
Score: 0.574 | |
Photo-reactive polyvinylalcohol for photo-immobilized microarray.
|
Score: 0.573 | |
Theoretically modeling microarray with the chemical equilibrium and thermodynamics.
|
Score: 0.573 | |
Analysis of microarray studies performed in the neurosciences.
|
Score: 0.572 | |
Microarray analysis of phosphatase gene expression in human melanoma.
|
Score: 0.572 | |
Pathology of melanoma.
|
Score: 0.571 | |
CD44v3 levels in primary cutaneous melanoma are predictive of prognosis: assessment by the use of tissue microarray.
|
Score: 0.570 | |
Microarray analysis reveals differences in gene expression of circulating CD8(+) T cells in melanoma patients and healthy donors.
|
Score: 0.570 | |
Analysis of DNA microarray data.
|
Score: 0.570 | |
The sharing of cDNA microarray data.
|
Score: 0.569 | |
Melanoma antigens that produce cell-mediated immune responses in melanoma patients: joint U.S.-U.S.S.R. study.
|
Score: 0.568 | |
Residual intrascleral and intraretinal melanoma: a concern with lamellar sclerouvectomy for uveal melanoma.
|
Score: 0.568 | |
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
|
Score: 0.568 | |
Immunobiology of melanoma. Gross and ultrastructural studies in a new melanoma model: the Sinclair swine.
|
Score: 0.568 | |
The familial occurrence of cutaneous melanoma, intraocular melanoma, and the dysplastic nevus syndrome.
|
Score: 0.568 | |
A pilot study of immunization with HLA-A2 matched allogeneic melanoma cells that secrete interleukin-2 in patients with metastatic melanoma.
|
Score: 0.568 | |
Advances in melanoma treatment and research. Proceedings of the 4th annual melanoma conference. Tampa, Florida, September 3-6, 1992.
|
Score: 0.568 | |
Malignant melanoma of the nose and paranasal sinuses and juvenile melanoma of the nose.
|
Score: 0.565 | |
Malignant melanoma in Uganda. (The relationship between pigmentation and malignant melanoma on the soles of the feet).
|
Score: 0.565 | |
Microarray technology and its application on nicotine research.
|
Score: 0.565 | |
Histological studies on malignant melanoma. Characteristics of primary malignant melanoma of the leptomeninges.
|
Score: 0.565 | |
A nutrigenomics database--integrated repository for publications and associated microarray data in nutrigenomics research.
|
Score: 0.564 | |
Nanodroplet profiling of enzymatic activities in a microarray.
|
Score: 0.564 | |
Melanogenesis in melanoma cells in tissue culture.
|
|