RIC: Research Interest Comparator

Chang, Alice, M.D.
Affiliation: UTSW
Email: not provided
Home Page: not provided
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 Abstract:
The Dallas Heart Study (DHS) is a probability-based cross-sectional study over-sampled for African-Americans designed to improve the understanding of preclinical determinants of cardiovascular disease. Through state-of-the art characterization of phenotypes and genotypes, this study is designed to generate and test hypotheses for improved diagnosis and treatment of cardiovascular disease.

1) Gender Differences in Circulating B-type Natriuretic Peptides
Further details are in the applicant’s research proposal along with preliminary data. We tested the hypothesis that BNP and NT-proBNP levels are regulated by sex hormones. Univariable linear regression and multivariable analyses were performed to evaluate the association of BNP and NT-proBNP with sex steroid hormone levels in women, ages 35 to 49. Log transformed SHBG, an indirect measure of the free estrogen to free testosterone ratio, was strongly associated with log BNP and log NT-proBNP.
2) Reynolds Women’s Study
Polycystic ovarian syndrome (PCOS) is a heterogeneous condition with the clinical features or biochemical findings of hyperandrogenism, anovulatory cycles and polycystic ovarian morphology (PCOM). An estimated 20% of reproductive age women have PCOM, and an estimated 10% of the population has PCOS. PCOS is also associated with metabolic factors recognized to increase cardiovascular risk – lipid abnormalities, insulin resistance and obesity. There is conflicting data about the translation of these risk factors to coronary artery disease and the relative contributions of the intermediate phenotypes of hyperandrogenism and PCOM. The Reynolds Women’s Study was designed to examine the associations of subclinical PCOS with subclinical coronary artery disease and coronary artery disease risk factors among reproductive age women. It is a subset of the DHS, women ages 35 to 49, with additional survey information about menstrual cycles, serologic measurements of total testosterone, SHBG, FSH and LH, and MRI data about ovarian structure.
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Current Research Experience in Women’s Cardiovascular Health
Alice Y. Chang, M.D

Keywords extracted from the abstract: [ eliminated words list ]
Count Word
6.000 1
6.000 2
1.457 abnormalities
1.615 additional
3.560 african-americans
1.514 age
4.332 ages
3.486 alice
1.710 analyses
3.582 anovulatory
6.000 applicant’s
2.500 art
3.595 artery
2.094 associated
1.438 association
2.237 associations
3.430 b-type
1.777 biochemical
8.374 bnp
5.060 cardiovascular
2.337 chang
1.744 characterization
2.013 circulating
0.816 clinical
1.780 condition
2.845 conflicting
2.483 contributions
3.497 coronary
2.036 cross-sectional
1.462 current
Count Word
4.353 cycles
2.633 dallas
2.310 data
5.058 designed
2.565 details
2.199 determinants
7.801 dhs
0.770 diagnosis
1.256 differences
2.916 disease
3.645 estimated
1.823 estrogen
1.613 evaluate
1.654 experience
2.216 factors
1.573 features
1.238 findings
2.942 free
2.288 fsh
1.313 further
2.061 gender
2.297 generate
2.408 genotypes
0.783 health
1.036 heart
2.329 heterogeneous
1.350 hormone
1.555 hormones
7.409 hyperandrogenism
2.511 hypotheses
Count Word
1.717 hypothesis
1.811 improve
1.613 improved
1.070 increase
2.056 indirect
1.363 information
1.292 insulin
1.897 intermediate
1.893 levels
1.942 lh
1.804 linear
1.553 lipid
6.844 log
1.800 measure
1.558 measurements
2.384 menstrual
1.655 metabolic
1.977 morphology
1.986 mri
3.353 multivariable
2.230 natriuretic
11.302 nt-probnp
1.935 obesity
4.769 ovarian
5.747 over-sampled
14.278 pcom
10.202 pcos
1.512 peptides
1.222 performed
4.732 phenotypes
Count Word
5.367 polycystic
1.201 population
2.442 preclinical
1.989 preliminary
4.827 probability-based
2.830 proposal
1.428 ratio
1.964 recognized
1.683 regression
1.961 regulated
1.501 relative
4.004 reproductive
1.313 resistance
5.974 reynolds
2.815 risk
2.587 serologic
2.834 sex
6.469 shbg
5.044 state-of-the
1.962 steroid
1.803 strongly
1.291 structure
5.633 subclinical
2.294 subset
1.140 syndrome
1.470 tested
3.728 testosterone
1.152 total
2.194 transformed
2.074 translation
Count Word
0.777 treatment
1.789 understanding
4.462 univariable
3.682 women
16.352 women’s
RIC Statistics:
Extraction Method: Keyword Count with Lexical Variants Added
Eliminated words list: MedlinePlus List
Similarity Method: Weighted keyword count
Weighting Method: Term Frequency * Inverse Document Frequency
Database: Medline Updates from current month
Publication Type: All
Score Calculation Method: Cosine Similarity Method
Sort by: Score
Submission date and time: 11-8-2005, 15:24:44
Computation time: 00:00:05

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Last updated: Tuesday, 08-Nov-2005 15:24:49 CST