RIC: Research Interest Comparator

Garcia, Christine, M.D., Ph.D.
Affiliation: UT Southwestern
Email: christine.garcia@utsouthwestern.edu
Home Page: not provided
New This Month | New This Year | Abstract | Selected Publications | RIC Statistics Results - FULL MEDLINE:

Anandamide induces necrosis in primary hepatic stellate cells.
Sören V Siegmund ... Robert F Schwabe
Hepatology 2005 May; 41(5)1085-95.

Score: 0.883
The chemical composition of fresh human lung parenchyma. An approach to the pathogenesis of lung emphysema.
C D Laros ... H M Janssen
Respiration 1972 ; 29(5)458-67.

Score: 0.471
Emphysema.
Med Times 1981 Jan; 109(1)34-43.

Score: 0.456
Emphysema.
Nurs Times 2004 Nov 23-29; 100(47)30.

Score: 0.456
Pressure-volume relations of lung and thoracic cage in pulmonary emphysema.
E Y TING ... H A LYONS
J Appl Physiol 1961 May; 16()517-21.

Score: 0.454
[Physiopathology of pulmonary emphysema. Analysis of structural changes in the pulmonary architecture and therapeutic implications]
S Nazari
Minerva Chir 1998 Apr; 53(4)261-75.

Score: 0.435
Pulmonary emphysema and lung function studies in patients with chronic non-specific lung diseases (C.N.S.L.D.).
J Kreukniet
Med Thorac 1965 ; 22(4)433-49.

Score: 0.432
The pattern of development of emphysema in the human lung.
K K Pump
Am Rev Respir Dis 1973 Sep; 108(3)610-20.

Score: 0.430
Elasticity of the lung in pulmonary emphysema.
R V Ebert
Ann Intern Med 1968 Nov; 69(5)903-8.

Score: 0.424
Single lung transplantation for pulmonary emphysema.
Lancet 1992 Jan; 339(8787)216-7.

Score: 0.424
Volume of emphysema.
P Turner ... W F Whimster
Thorax 1981 Dec; 36(12)932-7.

Score: 0.421
Alveolus formation: what have we learned from genetic studies?
Cong Yan ... Hong Du
J Appl Physiol 2004 Oct; 97(4)1543-8.

Score: 0.420
Lung patterns in emphysema.
J P Wyatt
Bull Physiopathol Respir (Nancy) 1973 Jul-Aug; 9(4)925-43.

Score: 0.419
Lung transplantation for emphysema.
M Estenne
Monaldi Arch Chest Dis 1998 Aug; 53(4)480-2.

Score: 0.419
Lung function in asthma and emphysema.
W APPEL
J Mich State Med Soc 1957 Feb; 56(2)213.

Score: 0.419
Localization of emphysema within the lung.
W K Morgan
Chest 1983 May; 83(5)836.

Score: 0.419
[External respiratory function in patients with primary pulmonary emphysema etiologically related to alpha 1-antitrypsin deficiency]
T E Gembitskaia ... V K Kuznetsova
Ter Arkh 1985 ; 57(3)91-6.

Score: 0.405
Tales from the crypt: beta-catenin in the development of juvenile polyps: commentary on the article by Iwamoto et al. on page 4.
Simon W Beaven ... Martín G Martín
Pediatr Res 2005 Jan; 57(1)1-3.

Score: 0.402
Nuclear accumulation of beta-catenin occurs commonly in the epithelial cells of juvenile polyps.
Michiko Iwamoto ... Dennis J Ahnen
Pediatr Res 2005 Jan; 57(1)4-9; discussion 1-3.

Score: 0.402
Pathophysiology of obstructive airways disease.
J W Gurney
Radiol Clin North Am 1998 Jan; 36(1)15-27.

Score: 0.402
FOCUS on the lung.
Cancer Bull 1952 Sep-Oct; 4(5)105-6.

Score: 0.397
[Pathogenesis of primary lung emphysema. Experimental studies]
W Schlick
Wien Med Wochenschr 1978 Jan; 128(2)42-6.

Score: 0.397
Diseases of the respiratory system. Neoplasms of the lung.
E D Gilby
Br Med J 1978 May; 1(6123)1331-3.

Score: 0.395
Scanning electronmicroscopic morphometry of emphysema in humans.
A Nagai ... W M Thurlbeck
Am J Respir Crit Care Med 1994 Nov; 150(5 Pt 1)1411-5.

Score: 0.394
Diseases of the respiratory system. Chronic bronchitis and emphysema.
A E Tattersfield
Br Med J 1978 Apr; 1(6120)1123-5.

Score: 0.393
Investigating stem cells in the lung.
S M Magdaleno ... F J DeMayo
Adv Pediatr 1998 ; 45()363-96.

Score: 0.391
[Oxidants and antioxidants: another look at the pathogenesis of pulmonary emphysema]
J Słodkowska
Postepy Hig Med Dosw 1991 ; 45(3-4)225-32.

Score: 0.391
Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema.
K Imai ... J D'Armiento
Am J Respir Crit Care Med 2001 Mar; 163(3 Pt 1)786-91.

Score: 0.389
[The clinical study of pulmonary emphysema with pulmonary fibrosis]
R Ji ... Q He
Zhonghua Jie He He Hu Xi Za Zhi 1999 Nov; 22(11)666-8.

Score: 0.389
[Emphysema]
Michel Fournier
Rev Prat 2004 Sep; 54(13)1419-23.

Score: 0.388
SPONTANEOUS PNEUMOTHORAX IN PULMONARY EMPHYSEMA.
L R CABIRAN ... M M ZISKIND
Dis Chest 1964 Nov; 46()571-7.

Score: 0.388
Lung function profiles in farmer's lung, asthma, chronic bronchitis and emphysema.
A R Sovijärvi
Eur J Respir Dis Suppl 1987 ; 154()94-100.

Score: 0.387
The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop.
Am Rev Respir Dis 1985 Jul; 132(1)182-5.

Score: 0.386
The pathobiological mechanisms of emphysema models: what do they have in common?
Rubin M Tuder ... Enid Neptune
Pulm Pharmacol Ther 2003 ; 16(2)67-78.

Score: 0.386
The role of collagenase in emphysema.
R Foronjy ... J D'Armiento
Respir Res 2001 ; 2(6)348-52.

Score: 0.386
Computed tomography of lung parenchyma.
E A Zerhouni
Bull N Y Acad Med 1986 Nov; 62(9)881-6.

Score: 0.385
[The surgical physiopathology of essential pulmonary emphysema and volume-reduction intervention]
S Nazari
Minerva Chir 1998 Nov; 53(11)899-918.

Score: 0.384
[Apoptosis in chronic obstructive pulmonary disease]
Atsushi Nagai
Nippon Rinsho 2003 Dec; 61(12)2126-32.

Score: 0.383
The lung.
Can Med Assoc J 1969 Feb; 100(7)349-51.

Score: 0.382
Lung function studies. V. Respiratory dead space in old age and in pulmonary emphysema.
W S FOWLER
J Clin Invest 1950 Nov; 29(11)1439-44.

Score: 0.379
Gene-environment interactions in asthma and other respiratory diseases.
Steven R Kleeberger ... David Peden
Annu Rev Med 2005 ; 56()383-400.

Score: 0.378
Clinical implications of new information on colorectal cancer genes.
Douglas K Rex
Rev Gastroenterol Disord 2002 ; 2(4)200-2.

Score: 0.378
A guide to lung function tests.
M C Apps
Br J Hosp Med 1992 Oct 7-20; 48(7)396-401.

Score: 0.378
Interstitial lung disease: basic mechanisms and genetic predisposition.
P A Lympany ... R M du Bois
Monaldi Arch Chest Dis 1997 Feb; 52(1)33-6.

Score: 0.377
Mediastinal emphysema with spontaneous pneumothorax.
D R McKAY
N Y State J Med 1950 Jan; 50(2)182-6.

Score: 0.376
Emphysema and the aging lung.
L CANDER ... W S BLUMENTHAL
Geriatrics 1963 Jun; 18()413-20.

Score: 0.374
[Evaluation of lung emphysema.]
H H MARX
Medizinische 1953 Dec; 50()1609-14.

Score: 0.374
The pathogenesis of lung emphysema. A hypothesis.
C D Laros
Respiration 1972 ; 29(5)442-57.

Score: 0.374
Congenital segmental emphysema of the lung.
I A BRECKLER
J Thorac Surg 1957 Aug; 34(2)177-83.

Score: 0.374
Diagnosing emphysema from the lung scan.
V Y Muir
Thorax 1971 Nov; 26(6)712-5.

Score: 0.374
Fixation of the lung for emphysema.
B E Heard ... E F Harding
Am Rev Respir Dis 1969 Jun; 99(6)966-7.

Score: 0.374
Emphysema and the senile lung.
I RAPPAPORT ... E MAYER
J Am Geriatr Soc 1954 Sep; 2(9)581-91.

Score: 0.374
Spontaneous pneumothorax and apical lung disease.
Br Med J 1971 Dec; 4(5787)573.

Score: 0.374
More inflammation than lung in emphysema.
William J Calhoun
Am J Respir Crit Care Med 2002 Mar; 165(5)730-1.

Score: 0.374
[Unilateral emphysema of the lung.]
L A LEVINA
Klin Med (Mosk) 1958 Apr; 36(4)45-8.

Score: 0.374
[Bullous emphysema and primary cancer of the lung (Note).]
S ROMANO
Policlinico [Prat] 1950 Mar; 57(10)319-20.

Score: 0.372
Plant evolutionary ecology.
Mark D Rausher
New Phytol 2005 Jan; 165(1)2-5.

Score: 0.371
[Pathogenesis and immediate results of surgical treatment for spontaneous non-specific pneumothorax]
Iu A Muromskiĭ ... A A Kharkin
Grud Serdechnososudistaia Khir 1993 Jul-Aug; (4)34-8.

Score: 0.371
Pulmonary fibrosis and emphysema: connective tissue disorders of the lung.
G J Laurent ... T D Tetley
Eur J Clin Invest 1984 Dec; 14(6)411-3.

Score: 0.371
Emphysema, lung disease and retinoic acid.
J Cantor
Nat Med 1997 Aug; 3(8)817.

Score: 0.370
Familial emphysema.
A HURST
Am Rev Respir Dis 1959 Jul; 80(1, Part 2)179-80.

Score: 0.370
New pathological findings in emphysema of childhood. 3. Unilateral congenital emphysema with hypoplasia--and compensatory emphysema of contralateral lung.
R Henderson ... L Reid
Thorax 1971 Mar; 26(2)195-205.

Score: 0.368
[Occupational lung diseases except silicosis. IV. Chronic bronchitis, emphysema and occupations: pulmonary emphysema after inhalation of irritant vapors especially ammonia.]
D BRILLE ... R LAURENT
Arch Mal Prof 1957 May-Jun; 18(3)320-36.

Score: 0.368
[Questionnaire to identify occupational exposure in individuals with primary lung cancer]
Rev Prat 2004 Oct; 54(15)1686-93.

Score: 0.367
The inherited nature of lung cancer: a pilot study.
M E Wood ... P A Bunn
Lung Cancer 2000 Nov; 30(2)135-44.

Score: 0.366
Damage to lung parenchyma in laboratory animals drowned in various environments.
S Loyka
Acta Med Leg Soc (Liege) 1985 ; 35(2)62-5.

Score: 0.365
What is your diagnosis? Pulmonary bullous emphysema with pneumothorax and subcutaneous emphysema.
B Gilroy ... C K Cebra
J Am Vet Med Assoc 1999 Aug; 215(4)475-6.

Score: 0.365
Increased content of neutrosoluble collagen and dialyzable hydroxyproline in panacinar emphysema and spontaneous pneumothorax.
H J Metivier ... R G Pariente
Exp Lung Res 1982 May; 3(2)129-36.

Score: 0.365
Pulmonary emphysema in a nonsmoker with normal alpha-1-antitrypsin.
K R Habenstein ... C L Fields
J Ky Med Assoc 1992 Jul; 90(7)327-30.

Score: 0.364
Genetic polymorphisms and environmental risk of lung cancer: a review.
Chikako Kiyohara ... Julian M Hopkin
Rev Environ Health 2004 Jan-Mar; 19(1)15-38.

Score: 0.363
Diffuse lung disease: product of genetic susceptibility and environmental encounters.
P A Lympany ... R M du Bois
Thorax 1997 Jan; 52(1)92-4.

Score: 0.361
Poissons' ratio of lung parenchyma and parenchymal interaction with bronchi.
J P Butler ... T Takishima
Jpn J Physiol 1986 ; 36(1)91-106.

Score: 0.361
Fragile lung in the Marfan syndrome.
J A Turner ... N N Stanley
Thorax 1976 Dec; 31(6)771-5.

Score: 0.360
Cellular sources of oxidants in the lung.
W J Piotrowski ... J Marczak
Int J Occup Med Environ Health 2000 ; 13(4)369-85.

Score: 0.359
Other smoking-affected pulmonary diseases.
S Murin ... R Matthay
Clin Chest Med 2000 Mar; 21(1)121-37, ix.

Score: 0.359
Lung cancer risk in families of nonsmoking probands: heterogeneity by age at diagnosis.
P Yang ... C E Aston
Genet Epidemiol 1999 Nov; 17(4)253-73.

Score: 0.359
The respiratory system. 2. Chronic bronchitis and emphysema.
D Siegler
Nurs Mirror 1977 Dec; 145(25)17-8.

Score: 0.358
Diagnosis of emphysema and air-trapping in high resolution computed tomography.
Marek Pasławski ... Janusz Złomaniec
Ann Univ Mariae Curie Sklodowska [Med] 2003 ; 58(2)262-9.

Score: 0.358
[Giant bullous emphysema of the lung simulating total pneumothorax.]
C RONZONI
Friuli Med 1958 May-Jun; 13(3)401-16.

Score: 0.358
Lung volume reduction surgery for pulmonary emphysema.
M Yoshida
Intern Med 1999 Feb; 38(2)79.

Score: 0.358
NEUROLOGICAL aspects of pulmonary emphysema.
Br Med J 1958 Feb; 1(5065)272-3.

Score: 0.358
CT of the lung in patients with pulmonary emphysema: diagnosis, quantification, and correlation with pathologic and physiologic findings.
E J Stern ... M S Frank
AJR Am J Roentgenol 1994 Apr; 162(4)791-8.

Score: 0.358
[Prevalence and specific features of pulmonary emphysema in patients with pulmonary tuberculosis]
V I Nechaev
Probl Tuberk 1997 ; (4)33-5.

Score: 0.357
[Community-acquired infections of the respiratory tract and lung parenchyma. Clinical and experimental aspects]
S Rosseau ... N Suttorp
Internist (Berl) 2000 Nov; 41(11)1158, 1161-9.

Score: 0.357
Histogenesis of striated muscle cells in the newborn lung parenchyma (rhabdomyomatosis), lung morphogenesis and development.
D Hardisson
Pathol Res Pract 1999 ; 195(10)725-6.

Score: 0.357
The effect of mechanical exsufflation on respiratory gas exchange in chronic pulmonary emphysema.
R M CHERNIACK
J Clin Invest 1953 Nov; 32(11)1192-6.

Score: 0.356
New concepts in the radiological assessment of COPD.
Harvey O Coxson ... Robert M Rogers
Semin Respir Crit Care Med 2005 Apr; 26(2)211-20.

Score: 0.355
[Subcutaneous emphysema in respiratory infections]
V Durić ... A Mijalković
Srp Arh Celok Lek 1966 Jun; 94(6)597-602.

Score: 0.354
[Pseudo-cavernous vesicular emphysema during viral lung diseases.]
G JOO
Minerva Pediatr 1952 Aug; 4(16)737-8.

Score: 0.354
[Animal models of chronic lung diseases (author's transl)]
F Palecek
Z Erkr Atmungsorgane 1976 Mar; 144(3)262-6.

Score: 0.354
[The so-called shock lung, a disease of lung parenchyma (author's transl)]
P von Wichert ... K Riesner
Langenbecks Arch Chir 1977 Dec; 344(3)157-69.

Score: 0.354
The respiratory muscles in emphysema.
J T Sharp
Clin Chest Med 1983 Sep; 4(3)421-32.

Score: 0.354
Disordered respiratory function in emphysema.
G Cumming
Proc R Soc Med 1969 Oct; 62(10)1027-9.

Score: 0.354
Assessing occupational and environmental exposures that cause lung disease.
Anne Bracker ... Eileen Storey
Clin Chest Med 2002 Dec; 23(4)695-705.

Score: 0.353
Structural alterations of lung parenchyma in the adult respiratory distress syndrome.
M Bachofen ... E R Weibel
Clin Chest Med 1982 Jan; 3(1)35-56.

Score: 0.352
[Hemocoagulating and fibrinolytic elements of the lung parenchyma in tuberculosis]
N S Ruseĭkin
Probl Tuberk 1973 ; 51(3)79-83.

Score: 0.351
Biochemical alterations of lung structure as predictors of chronic lung disease.
J A Last
Environ Health Perspect 1983 Oct; 52()159-63.

Score: 0.351
The impact of emphysema.
M C Schwaid
Am J Nurs 1970 Jun; 70(6)1247-50.

Score: 0.351
Glycosaminoglycans of bovine lung parenchyma and pleura.
F S Wusteman
Experientia 1972 Aug; 28(8)887-8.

Score: 0.351
Hysteresis of airways and lung parenchyma.
V Brusasco ... R Pellegrino
Respir Med 1995 May; 89(5)317-22.

Score: 0.351
Abstract:
The primary function of the respiratory system is to provide adequate gas exchange for the organism. Just like other organ systems, genetics has an important impact on many aspects of the respiratory system, from the shape of the thoracic cage to the intrinsic response of the lung parenchyma to various insults. We are using genetic approaches to identify the primary determinants of lung disease, especially diseases of lung parenchyma such as emphysema and pulmonary fibrosis.

Our approach is to collect the medical history of families containing a number of affected individuals. We look for the pattern of inheritance, the phenotypic heterogeneity, and evidence of interactions between specific environmental exposures. Blood samples and additional clinical information are collected from the affecteds and the first-degree at-risk individuals. These provide us with the resources for determining the genetic underpinnings of these diseases.

We have recently found a gene defective in a specific form of emphysema, familial spontaneous pneumothorax, which results in the formation of multiple holes at the periphery of the lung. The specific role of this protein in lung development and its cellular function is a focus of the laboratory.
Keywords extracted from the abstract: [ eliminated words list ]
Count Word
1.615 additional
2.052 adequate
1.572 affected
5.015 affecteds
1.396 approach
1.964 approaches
1.723 aspects
3.236 at-risk
0.651 blood
2.892 cage
1.428 cellular
0.816 clinical
3.050 collect
1.777 collected
1.478 containing
2.282 defective
2.199 determinants
2.047 determining
1.000 development
0.796 disease
1.878 diseases
5.215 emphysema
1.576 environmental
1.712 especially
1.738 exchange
2.426 exposures
2.126 familial
1.890 families
1.883 fibrosis
3.181 first-degree
Count Word
2.061 focus
1.398 form
1.281 formation
1.784 gas
0.898 gene
2.388 genetic
0.705 genetics
2.222 heterogeneity
1.165 history
3.122 holes
1.705 identify
1.742 impact
1.237 important
3.352 individuals
1.363 information
2.612 inheritance
3.246 insults
1.557 interactions
2.191 intrinsic
2.263 just
1.348 laboratory
2.704 look
4.370 lung
0.878 medical
1.343 multiple
1.625 organ
2.290 organism
0.926 other
5.483 parenchyma
1.475 pattern
Count Word
2.707 periphery
2.367 phenotypic
2.706 pneumothorax
2.449 primary
0.701 protein
3.041 provide
1.261 pulmonary
1.689 recently
2.131 resources
2.879 respiratory
1.024 response
0.741 results
1.068 role
1.379 samples
2.136 shape
3.209 specific
1.702 spontaneous
1.937 system
1.346 systems
1.843 thoracic
4.023 underpinnings
0.916 us
0.886 using
1.344 various
RIC Statistics:
Extraction Method: Keyword Count with Lexical Variants Added
Eliminated words list: MedlinePlus List
Similarity Method: Weighted keyword count
Weighting Method: Term Frequency * Inverse Document Frequency
Database: Medline abstracts (1967 - Present)
Publication Type: All
Score Calculation Method: Cosine Similarity Method
Sort by: Score
Submission date and time: 8-24-2005, 18:32:1
Computation time: 00:00:04
Last updated: Wednesday, 24-Aug-2005 18:32:05 CDT