RIC > Researcher Profiles > Garcia, Christine

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RIC: Research Interest Comparator

Garcia, Christine, M.D., Ph.D.
Affiliation: UT Southwestern
Email: christine.garcia@utsouthwestern.edu
Home Page: not provided
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Abstract:
The primary function of the respiratory system is to provide adequate gas exchange for the organism. Just like other organ systems, genetics has an important impact on many aspects of the respiratory system, from the shape of the thoracic cage to the intrinsic response of the lung parenchyma to various insults. We are using genetic approaches to identify the primary determinants of lung disease, especially diseases of lung parenchyma such as emphysema and pulmonary fibrosis.

Our approach is to collect the medical history of families containing a number of affected individuals. We look for the pattern of inheritance, the phenotypic heterogeneity, and evidence of interactions between specific environmental exposures. Blood samples and additional clinical information are collected from the affecteds and the first-degree at-risk individuals. These provide us with the resources for determining the genetic underpinnings of these diseases.

We have recently found a gene defective in a specific form of emphysema, familial spontaneous pneumothorax, which results in the formation of multiple holes at the periphery of the lung. The specific role of this protein in lung development and its cellular function is a focus of the laboratory.

Keywords extracted from the abstract: [ eliminated words list ]

Count	Word
1.615	additional
2.052	adequate
1.572	affected
5.015	affecteds
1.396	approach
1.964	approaches
1.723	aspects
3.236	at-risk
0.651	blood
2.892	cage
1.428	cellular
0.816	clinical
3.050	collect
1.777	collected
1.478	containing
2.282	defective
2.199	determinants
2.047	determining
1.000	development
0.796	disease
1.878	diseases
5.215	emphysema
1.576	environmental
1.712	especially
1.738	exchange
2.426	exposures
2.126	familial
1.890	families
1.883	fibrosis
3.181	first-degree

Count	Word
2.061	focus
1.398	form
1.281	formation
1.784	gas
0.898	gene
2.388	genetic
0.705	genetics
2.222	heterogeneity
1.165	history
3.122	holes
1.705	identify
1.742	impact
1.237	important
3.352	individuals
1.363	information
2.612	inheritance
3.246	insults
1.557	interactions
2.191	intrinsic
2.263	just
1.348	laboratory
2.704	look
4.370	lung
0.878	medical
1.343	multiple
1.625	organ
2.290	organism
0.926	other
5.483	parenchyma
1.475	pattern

Count	Word
2.707	periphery
2.367	phenotypic
2.706	pneumothorax
2.449	primary
0.701	protein
3.041	provide
1.261	pulmonary
1.689	recently
2.131	resources
2.879	respiratory
1.024	response
0.741	results
1.068	role
1.379	samples
2.136	shape
3.209	specific
1.702	spontaneous
1.937	system
1.346	systems
1.843	thoracic
4.023	underpinnings
0.916	us
0.886	using
1.344	various

RIC Statistics:

Extraction Method: Keyword Count with Lexical Variants Added

Eliminated words list: MedlinePlus List

Weighting Method: Term Frequency * Inverse Document Frequency

Database: Medline Updates from current month

Publication Type: All

Score Calculation Method: Cosine Similarity Method

Sort by: Score

Submission date and time: 8-24-2005, 18:32:1

Computation time: 00:00:04

Last updated: Wednesday, 24-Aug-2005 18:32:05 CDT