RIC: Research Interest Comparator

Garcia, Christine, M.D., Ph.D.
Affiliation: UT Southwestern
Email: christine.garcia@utsouthwestern.edu
Home Page: not provided
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 Abstract:
The primary function of the respiratory system is to provide adequate gas exchange for the organism. Just like other organ systems, genetics has an important impact on many aspects of the respiratory system, from the shape of the thoracic cage to the intrinsic response of the lung parenchyma to various insults. We are using genetic approaches to identify the primary determinants of lung disease, especially diseases of lung parenchyma such as emphysema and pulmonary fibrosis.

Our approach is to collect the medical history of families containing a number of affected individuals. We look for the pattern of inheritance, the phenotypic heterogeneity, and evidence of interactions between specific environmental exposures. Blood samples and additional clinical information are collected from the affecteds and the first-degree at-risk individuals. These provide us with the resources for determining the genetic underpinnings of these diseases.

We have recently found a gene defective in a specific form of emphysema, familial spontaneous pneumothorax, which results in the formation of multiple holes at the periphery of the lung. The specific role of this protein in lung development and its cellular function is a focus of the laboratory.
Keywords extracted from the abstract: [ eliminated words list ]
Count Word
1.615 additional
2.052 adequate
1.572 affected
5.015 affecteds
1.396 approach
1.964 approaches
1.723 aspects
3.236 at-risk
0.651 blood
2.892 cage
1.428 cellular
0.816 clinical
3.050 collect
1.777 collected
1.478 containing
2.282 defective
2.199 determinants
2.047 determining
1.000 development
0.796 disease
1.878 diseases
5.215 emphysema
1.576 environmental
1.712 especially
1.738 exchange
2.426 exposures
2.126 familial
1.890 families
1.883 fibrosis
3.181 first-degree
Count Word
2.061 focus
1.398 form
1.281 formation
1.784 gas
0.898 gene
2.388 genetic
0.705 genetics
2.222 heterogeneity
1.165 history
3.122 holes
1.705 identify
1.742 impact
1.237 important
3.352 individuals
1.363 information
2.612 inheritance
3.246 insults
1.557 interactions
2.191 intrinsic
2.263 just
1.348 laboratory
2.704 look
4.370 lung
0.878 medical
1.343 multiple
1.625 organ
2.290 organism
0.926 other
5.483 parenchyma
1.475 pattern
Count Word
2.707 periphery
2.367 phenotypic
2.706 pneumothorax
2.449 primary
0.701 protein
3.041 provide
1.261 pulmonary
1.689 recently
2.131 resources
2.879 respiratory
1.024 response
0.741 results
1.068 role
1.379 samples
2.136 shape
3.209 specific
1.702 spontaneous
1.937 system
1.346 systems
1.843 thoracic
4.023 underpinnings
0.916 us
0.886 using
1.344 various
RIC Statistics:
Extraction Method: Keyword Count with Lexical Variants Added
Eliminated words list: MedlinePlus List
Similarity Method: Weighted keyword count
Weighting Method: Term Frequency * Inverse Document Frequency
Database: Medline Updates from current year
Publication Type: All
Score Calculation Method: Cosine Similarity Method
Sort by: Score
Submission date and time: 8-24-2005, 18:32:1
Computation time: 00:00:04

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Last updated: Wednesday, 24-Aug-2005 18:32:05 CDT