 |
RIC: Research Interest Comparator |
|
Professor
Affiliation: UTSW
Office: not provided
Phone #: not provided
Fax: not provided
Email: garner@swmed.edu
Home Page: not provided
Lab: not provided
Basic and applied biomedical research is advancing into proteomics via a foundation in genomics and transcriptomics. The analysis of the proteome will require technologies such as mass spec or protein microarrays to decipher its complexity. We developed and applied a new light-directed oligonucleotide array synthesizer that can construct 200,000 genetic analysis features in hours directly from digital data onto a microscope slide. We have now shown by modifying one of these devices that, when coupled with unique new chemistries for the creation of sub-monomer protective groups for peptoids, can be adapted to fabricate custom protein analysis microarrays. Our focus will be to exploit these peptide-like molecules (peptoids) via the creation of large libraries on microarrays to identify and optimize these compounds for affinity and specificity as protein-binding reagents. We propose to develop the hardware, software and chemistries necessary to rapidly create custom proteomics arrays and then apply them to a host of interesting applications to demonstrate the utility and value of such arrays.
Extraction Method: Keyword Count with Lexical Variants Added-
Eliminated words list: MedlinePlus List
-
Similarity Method: Weighted Keyword Count
-
Weighting Method: Term Frequency * Inverse Document Frequency
-
Database: Medline Updates from current month
-
Publication Type: All
-
Score Calculation Method: Cosine Similarity Method
-
Sort by: Score
-
Results computed on: 6/9/2006