RIC: Research Interest Comparator

Hilmer, Jonathan, Student
Affiliation: Montana State University, Dept of Chemistry
Email: jkhilmer@gmail.com
Home Page: http://www.chemistry.montana.edu/~bbothner/
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No matching results
 Abstract:
The concerted protein motion that is part of a multi-component complex is rarely obvious from the high resolution three-dimensional structure. Protein function is intimately connected to dynamics and therefore knowledge of the frequency, range, and coordination of motion by supramolecular complexes is critical to understanding how they function. My lab uses viruses as a paradigm for studying protein dynamics in supramolecular complexes. Viruses are also timely subjects for health, nanotechnology and bio-defense related research. The life cycle of a typical virus traverses a range of environments. Assembly, maturation, cellular uptake, and genome delivery require numerous structural calisthenics. It is our goal to understand the role of protein dynamics in viral capsid protein function. The extremely large size and icosahedral architecture of virus capsids limit the use of many standard techniques for studying protein motion such as NMR and FRET. To overcome these problems, we employ an array of biophysical techniques to study the solution phase behavior of viruses. Kinetic hydrolysis, an approach being developed in our lab, is a straight-forward and powerful technique for determining the dynamic regions within a single protein or in the context of a multi-component complex. Site-directed chemical labeling using small molecule probes is a complementary method that allows the solvent accessible space of a protein or protein complex to be surveyed.
Keywords extracted from the abstract: [ eliminated words list ]
Count Word
2.713 accessible
1.997 allows
1.396 approach
2.589 architecture
2.389 array
2.166 assembly
1.356 behavior
5.962 bio-defense
2.884 biophysical
5.051 calisthenics
2.553 capsid
3.544 capsids
1.428 cellular
1.357 chemical
1.847 complementary
3.385 complex
3.402 complexes
3.218 concerted
2.513 connected
2.090 context
2.508 coordination
1.660 critical
1.557 cycle
1.639 delivery
2.047 determining
1.308 developed
1.992 dynamic
5.099 dynamics
3.133 employ
2.558 environments
Count Word
2.206 extremely
1.433 frequency
3.504 fret
1.817 genome
2.270 goal
0.783 health
0.994 high
1.960 hydrolysis
3.808 icosahedral
3.385 intimately
2.060 kinetic
1.702 knowledge
4.423 lab
1.907 labeling
1.349 large
1.375 life
2.129 limit
2.056 maturation
1.099 method
1.865 molecule
5.286 motion
8.298 multi-component
2.566 my
3.634 nanotechnology
2.093 nmr
2.104 numerous
2.486 obvious
2.537 overcome
2.542 paradigm
1.478 part
Count Word
1.363 phase
2.463 powerful
1.913 probes
1.589 problems
3.372 protein
2.750 range
2.326 rarely
1.473 regions
1.284 related
2.003 require
1.975 resolution
1.068 role
1.329 single
2.291 site-directed
1.444 size
1.271 small
1.630 solution
2.385 solvent
1.780 space
1.569 standard
4.680 straight-forward
1.545 structural
1.291 structure
4.689 studying
1.193 subjects
6.780 supramolecular
2.680 surveyed
1.323 technique
2.731 techniques
2.181 three-dimensional
Count Word
3.012 timely
4.287 traverses
1.983 typical
2.224 understand
1.789 understanding
1.560 uptake
2.363 uses
0.886 using
1.198 viral
2.378 virus
5.233 viruses
RIC Statistics:
Extraction Method: Keyword Count with Lexical Variants Added
Eliminated words list: MedlinePlus List
Similarity Method: Weighted keyword count
Weighting Method: Term Frequency * Inverse Document Frequency
Database: Medline Updates from current month
Publication Type: All
Score Calculation Method: Cosine Similarity Method
Sort by: Score
Submission date and time: 12-18-2007, 15:42:28
Computation time: 00:00:04

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Last updated: Tuesday, 18-Dec-2007 15:42:32 CST