RIC: Research Interest Comparator

Klaus Braut, Ph.D.
Affiliation: not provided
Email: not provided
Home Page: not provided
New This Month | New This Year | Abstract | Selected Publications | RIC Statistics Results - FULL MEDLINE:

[Introduction of the high throughput screening system]
Y Li
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2000 Apr; 22(2)103-5.
Score: 0.587
[Assay in high throughput screening]
K Arai
Nippon Yakurigaku Zasshi 2001 Aug; 118(2)81-8.
Score: 0.554
High-throughput screening assays for the identification of chemical probes.
James Inglese ... Douglas S Auld
Nat Chem Biol 2007 Aug; 3(8)466-79.
Score: 0.528
Design and implementation of high throughput screening assays.
Ricardo Macarrón ... Robert P Hertzberg
Methods Mol Biol 2002 ; 190()1-29.
Score: 0.528
High Throughput Screening Assay for UDP-Glucuronosyltransferase 1A1 Glucuronidation Profiling.
O V Trubetskoy ... V S Trubetskoy
Assay Drug Dev Technol 2007 Jun; 5(3)343-54.
Score: 0.503
Introduction of the high throughput screening system.
Y Li
Chin Med Sci J 2001 Sep; 16(3)179-81.
Score: 0.502
Measuring intracellular calcium fluxes in high throughput mode.
Chris Chambers ... Andreas Sewing
Comb Chem High Throughput Screen 2003 Jun; 6(4)355-62.
Score: 0.500
Comparison of high throughput screening technologies for luminescence cell-based reporter screens.
Gregory F Davis ... Sandra L Nelson
J Biomol Screen 2002 Feb; 7(1)67-77.
Score: 0.497
Microbiological high throughput screening: an opportunity for the lead discovery process.
M H Beydon ... J Becquart
J Biomol Screen 2000 Feb; 5(1)13-22.
Score: 0.490
High-throughput screening: update on practices and success.
Sandra Fox ... Michael Biros
J Biomol Screen 2006 Oct; 11(7)864-9.
Score: 0.486
High throughput drug screening.
Jill Heemskerk
Amyotroph Lateral Scler Other Motor Neuron Disord 2004 Sep; 5 Suppl 1()19-21.
Score: 0.485
[Does high throughput screening work?]
Ikuo Mitsui
Nippon Yakurigaku Zasshi 2007 Apr; 129(4)281-5.
Score: 0.471
Advances in high throughput screening.
Gareth P Williams
Drug Discov Today 2004 Jun; 9(12)515-6.
Score: 0.471
Parallel and multiplexed bead-based assays and encoding strategies.
Boon-ek Yingyongnarongkul ... Mark Bradley
Comb Chem High Throughput Screen 2003 Nov; 6(7)577-87.
Score: 0.470
G-protein coupled receptor assays: to measure affinity or efficacy that is the question.
C Williams ... A Sewing
Comb Chem High Throughput Screen 2005 Jun; 8(4)285-92.
Score: 0.467
[High throughput pharmacology for drug discovery]
H Ozaki ... K Kohama
Nippon Yakurigaku Zasshi 2001 Sep; 118(3)187-96.
Score: 0.465
[The role of high throughput screening in the early stage of drug research]
György Miklós Keserü
Acta Pharm Hung 2004 ; 74(1)5-10.
Score: 0.459
Cellular assays in HTS.
Patricia Johnston
Methods Mol Biol 2002 ; 190()107-16.
Score: 0.459
Beta galactosidase enzyme fragment complementation as a novel technology for high throughput screening.
Richard M Eglen ... Rajendra Singh
Comb Chem High Throughput Screen 2003 Jun; 6(4)381-7.
Score: 0.455
Use of mixture distributions to deconvolute the behavior of "hits" and controls in high-throughput screening data.
Stephen Buxser ... Darryl L Chapman
Anal Biochem 2007 Feb; 361(2)197-209.
Score: 0.454
Novel miniaturized systems in high-throughput screening.
Bronwyn J Battersby ... Matt Trau
Trends Biotechnol 2002 Apr; 20(4)167-73.
Score: 0.452
Screening and synthesis: high throughput technologies applied to parasitology.
R E Morgan ... N J Westwood
Parasitology 2004 ; 128 Suppl()S71-9.
Score: 0.451
Image-based screening: a technology in transition.
Peter Ramm
Curr Opin Biotechnol 2005 Feb; 16(1)41-8.
Score: 0.448
Components of successful lead generation.
Andrew M Davis ... Alan C Tinker
Curr Top Med Chem 2005 ; 5(4)421-39.
Score: 0.447
Statistical analysis of systematic errors in high-throughput screening.
Dmytro Kevorkov ... Vladimir Makarenkov
J Biomol Screen 2005 Sep; 10(6)557-67.
Score: 0.446
HTS technologies in biopharmaceutical discovery.
Ge Wu ... Stephen K Doberstein
Drug Discov Today 2006 Aug; 11(15-16)718-24.
Score: 0.437
Luminescent proteins from Aequorea victoria: applications in drug discovery and in high throughput analysis.
S K Deo ... S Daunert
Fresenius J Anal Chem 2001 Feb; 369(3-4)258-66.
Score: 0.433
High throughput screening on a low budget.
M A Palmer
Nat Biotechnol 1996 Apr; 14(4)513-5.
Score: 0.430
Detection trends in high throughput screening.
John G Westerfeld
Anal Bioanal Chem 2002 Jan; 372(1)43.
Score: 0.430
Unit automation in high throughput screening.
Karl C Menke
Methods Mol Biol 2002 ; 190()195-212.
Score: 0.430
Screening for content--the evolution of high throughput.
Alan Dove
Nat Biotechnol 2003 Aug; 21(8)859-64.
Score: 0.430
Whole cell strategies based on lux genes for high throughput applications toward new antimicrobials.
Lorenzo Galluzzi ... Matti Karp
Comb Chem High Throughput Screen 2006 Aug; 9(7)501-14.
Score: 0.430
Oncology drug discovery applications using the FMAT 8100 HTS system.
Jennifer Y Lee ... Dennis S France
J Biomol Screen 2003 Feb; 8(1)81-8.
Score: 0.429
Management and maintenance of high throughput screening systems.
Barbara Hynd
Methods Mol Biol 2002 ; 190()229-45.
Score: 0.426
An empirical process for the design of high-throughput screening deck filters.
Bradley C Pearce ... David A Stock
J Chem Inf Model 2006 May-Jun; 46(3)1060-8.
Score: 0.424
The application of high-throughput screening to novel lead discovery.
B A Kenny ... J M Treherne
Prog Drug Res 1998 ; 51()245-69.
Score: 0.424
Development of a miniaturized 384-well high throughput screen for the detection of substrates of cytochrome P450 2D6 and 3A4 metabolism.
I Kariv ... K R Oldenburg
J Biomol Screen 2001 Apr; 6(2)91-9.
Score: 0.422
Fluorescence polarization and anisotropy in high throughput screening: perspectives and primer.
J C Owicki
J Biomol Screen 2000 Oct; 5(5)297-306.
Score: 0.421
High throughput screening in drug discovery.
A Carnero
Clin Transl Oncol 2006 Jul; 8(7)482-90.
Score: 0.421
Transfected cell lines as tools for high throughput screening: a call for standards.
L Pagliaro ... M Praestegaard
J Biomol Screen 2001 Jun; 6(3)133-6.
Score: 0.418
Integrative functional assays, chemical genomics and high throughput screening: harnessing signal transduction pathways to a common HTS readout.
Ethan S Burstein ... Mark R Brann
Curr Pharm Des 2006 ; 12(14)1717-29.
Score: 0.418
Image-based screening of signal transduction assays.
Peter Ramm ... Nick Thomas
Sci STKE 2003 Apr; 2003(177)PE14.
Score: 0.417
Comparison of assay technologies for a tyrosine kinase assay generates different results in high throughput screening.
Matthew A Sills ... Jinzi J Wu
J Biomol Screen 2002 Jun; 7(3)191-214.
Score: 0.415
Homogeneous pharmacologic and cell-based screens provide diverse strategies in drug discovery: somatostatin antagonists as a case study.
J R Zysk ... W R Baumbach
Comb Chem High Throughput Screen 1998 Dec; 1(4)171-83.
Score: 0.414
Mini-review: Combinatorial approaches for the design of novel coating systems.
Dean C Webster ... Shane J Stafslien
Biofouling 2007 ; 23(3)179-92.
Score: 0.413
Targeting chemical inputs and optimising HTS for agrochemical discovery.
Stephen C Smith ... Martin J Rice
Comb Chem High Throughput Screen 2005 Nov; 8(7)577-87.
Score: 0.412
[High throughput screening in the process of drug discovery]
Tomokazu Ueki
Nippon Yakurigaku Zasshi 2007 Apr; 129(4)276-80.
Score: 0.410
A high throughput screening assay to screen for CYP2E1 metabolism and inhibition using a fluorogenic vivid p450 substrate.
Bryan D Marks ... Olga V Trubetskoy
Assay Drug Dev Technol 2002 Nov; 1(1 Pt 1)73-81.
Score: 0.409
Perfect high throughput screening assay: a crucial technique for drug discovery.
Guan-hua Du
Acta Pharmacol Sin 2005 Oct; 26(10)1174.
Score: 0.408
Throughput.
R C Thurow
Angle Orthod 1987 Oct; 57(4)268-70.
Score: 0.408
High-throughput screening approaches for investigating drug metabolism and pharmacokinetics.
S A Roberts
Xenobiotica 2001 Aug-Sep; 31(8-9)557-89.
Score: 0.400
Challenges of high throughput screening against cell surface receptors.
J S Major
J Recept Signal Transduct Res 1995 Jan-Mar; 15(1-4)595-607.
Score: 0.398
Applications of fluorescent polymer superquenching to high throughput screening assays for protein kinases.
Wensheng Xia ... David G Whitten
Assay Drug Dev Technol 2004 Apr; 2(2)183-92.
Score: 0.398
High-throughput screening: new technology for the 21st century.
R P Hertzberg ... A J Pope
Curr Opin Chem Biol 2000 Aug; 4(4)445-51.
Score: 0.395
Technological advances in high-throughput screening.
Bailing Liu ... Jie Hu
Am J Pharmacogenomics 2004 ; 4(4)263-76.
Score: 0.395
The assay of vitamin B(4).
V Reader
Biochem J 1930 ; 24(6)1827-31.
Score: 0.393
Miniaturization of absorbance assays using the fluorescent properties of white microplates.
Paul Zuck ... Marc Ferrer
Anal Biochem 2005 Jul; 342(2)254-9.
Score: 0.393
Statistical and graphical methods for quality control determination of high-throughput screening data.
Bert Gunter ... Andy Liaw
J Biomol Screen 2003 Dec; 8(6)624-33.
Score: 0.393
A novel HIV-1 antiviral high throughput screening approach for the discovery of HIV-1 inhibitors.
Wade S Blair ... Amy K Patick
Antiviral Res 2005 Feb; 65(2)107-16.
Score: 0.393
Bioluminescent assays for high-throughput screening.
Frank Fan ... Keith V Wood
Assay Drug Dev Technol 2007 Feb; 5(1)127-36.
Score: 0.391
Smart screening: approaches to efficient HTS.
M F Engels ... P Venkatarangan
Curr Opin Drug Discov Devel 2001 May; 4(3)275-83.
Score: 0.390
Analysis of purified tubulin in high concentration of glutamate for application in high throughput screening for microtubule-stabilizing agents.
Hui Dong ... Wei Hu
Assay Drug Dev Technol 2004 Dec; 2(6)621-8.
Score: 0.389
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation.
Alex Crowe ... Virginia M-Y Lee
Biochem Biophys Res Commun 2007 Jun; 358(1)1-6.
Score: 0.389
Assay technologies for screening ion channel targets.
L C Mattheakis ... A Savchenko
Curr Opin Drug Discov Devel 2001 Jan; 4(1)124-34.
Score: 0.389
Adaptation of aequorin functional assay to high throughput screening.
Emmanuel Le Poul ... Michel Detheux
J Biomol Screen 2002 Feb; 7(1)57-65.
Score: 0.388
A high throughput luminescent assay for glycogen synthase kinase-3beta inhibitors.
Andrea Baki ... György M Keserü
Assay Drug Dev Technol 2007 Feb; 5(1)75-83.
Score: 0.384
Further comparison of primary hit identification by different assay technologies and effects of assay measurement variability.
Xiang Wu ... Ji-Hu Zhang
J Biomol Screen 2005 Sep; 10(6)581-9.
Score: 0.384
A multi-modality assay platform for ultra-high throughput screening.
A Fowler ... C Norey
Curr Pharm Biotechnol 2000 Nov; 1(3)265-81.
Score: 0.383
Strategies and Techniques for Identification of Novel Bioactive Compounds - CHI's Second Annual Conference.
H Kubinyi
IDrugs 1998 Dec; 1(8)883-6.
Score: 0.382
Assay development and high-throughput screening of caspases in microfluidic format.
Ge Wu ... Bill Janzen
Comb Chem High Throughput Screen 2003 Jun; 6(4)303-12.
Score: 0.381
Robotic assay of sphingomyelinase activity for high throughput screening.
A G Barbone ... D C Argentieri
Methods Enzymol 2000 ; 311()168-76.
Score: 0.379
Simple absorbance-based assays for ultra-high throughput screening.
P Lavery ... A J Pope
J Biomol Screen 2001 Feb; 6(1)3-9.
Score: 0.379
The GreenScreen genotoxicity assay: a screening validation programme.
P A Cahill ... R M Walmsley
Mutagenesis 2004 Mar; 19(2)105-19.
Score: 0.378
High content cellular screening.
Oliver Rausch
Curr Opin Chem Biol 2006 Aug; 10(4)316-20.
Score: 0.377
HTS in the new millennium: the role of pharmacology and flexibility.
J A Landro ... P M Sweetnam
J Pharmacol Toxicol Methods 2000 Jul-Aug; 44(1)273-89.
Score: 0.377
A high throughput screening method for the selection of zeolites for binding cations.
Edel M Minogue ... Michael T Janicke
Chem Commun (Camb) 2005 Sep; (33)4167-8.
Score: 0.374
Cellular fluorescent indicators and voltage/ion probe reader (VIPR) tools for ion channel and receptor drug discovery.
Jesús E González ... Michael P Maher
Receptors Channels 2002 ; 8(5-6)283-95.
Score: 0.373
HTS Technologies--IBC Informa Conference.
H Kubinyi
IDrugs 2001 Feb; 4(2)168-73.
Score: 0.373
High throughput screening in agrochemical research.
Klaus Tietjen ... Klaus Stenzel
Comb Chem High Throughput Screen 2005 Nov; 8(7)589-94.
Score: 0.373
High throughput fluorescence assays for the measurement of mitochondrial activity in intact human neuroblastoma cells.
A J Woollacott ... P B Simpson
J Biomol Screen 2001 Dec; 6(6)413-20.
Score: 0.373
A high throughput sphingomyelinase assay.
D F Hassler ... G K Smith
Methods Enzymol 2000 ; 311()176-84.
Score: 0.371
Virtual screening methods that complement HTS.
Florence L Stahura ... Jürgen Bajorath
Comb Chem High Throughput Screen 2004 Jun; 7(4)259-69.
Score: 0.371
Development of a miniaturized assay for the high-throughput screening program for poly(ADP-ribose) polymerase-1.
S Lee ... B H Lee
Methods Find Exp Clin Pharmacol 2005 Nov; 27(9)617-22.
Score: 0.370
Screening cottonseed for aflatoxins.
M E Whitten
J Am Oil Chem Soc 1969 Jan; 46(1)39-40.
Score: 0.370
Tecniche "high throughput" in patologia umana. Biostatistica. "High throughput" technique in human pathology. Biostatistics.
E Biganzoli ... P Boracchi
Pathologica 2005 Aug; 97(4)190-1.
Score: 0.370
Genotoxicity screening: the slow march to the future.
Richard M Walmsley
Expert Opin Drug Metab Toxicol 2005 Aug; 1(2)261-8.
Score: 0.370
Fluorescence polarization assays for high throughput screening of G protein-coupled receptors.
P Banks ... L Prystay
J Biomol Screen 2000 Jun; 5(3)159-68.
Score: 0.370
Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells.
Priya Kunapuli ... Berta Strulovici
Assay Drug Dev Technol 2005 Feb; 3(1)17-26.
Score: 0.370
High throughput screening (HTS) for phototoxicity hazard using the in vitro 3T3 neutral red uptake assay.
P A Jones ... A V King
Toxicol In Vitro 2003 Oct-Dec; 17(5-6)703-8.
Score: 0.369
In vitro preclinical lead optimisation technologies (PLOTs) in pharmaceutical development.
Christopher K Atterwill ... Mark G Wing
Toxicol Lett 2002 Feb; 127(1-3)143-51.
Score: 0.368
Aptamers as reagents for high-throughput screening.
L S Green ... N Janjic
Biotechniques 2001 May; 30(5)1094-6, 1098, 1100 passim.
Score: 0.367
Use of fluorescence polarization detection for the measurement of fluopeptidetm binding to G protein-coupled receptors.
A Gagne ... S D Hurt
J Recept Signal Transduct Res 2002 Feb-Nov; 22(1-4)333-43.
Score: 0.367
Determining the optimal size of small molecule mixtures for high throughput NMR screening.
Kelly A Mercier ... Robert Powers
J Biomol NMR 2005 Mar; 31(3)243-58.
Score: 0.366
A pair of new statistical parameters for quality control in RNA interference high-throughput screening assays.
Xiaohua Douglas Zhang
Genomics 2007 Apr; 89(4)552-61.
Score: 0.366
G-protein-coupled receptors in drug discovery: nanosizing using cell-free technologies and molecular biology approaches.
Wayne R Leifert ... Edward J McMurchie
J Biomol Screen 2005 Dec; 10(8)765-79.
Score: 0.365
Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader.
Peter Hodder ... Berta Strulovici
J Biomol Screen 2004 Aug; 9(5)417-26.
Score: 0.365
Microchip-based high-throughput screening analysis of combinatorial libraries.
Julia Khandurina ... András Guttman
Curr Opin Chem Biol 2002 Jun; 6(3)359-66.
Score: 0.365
Development of a high throughput equilibrium dialysis method.
I Kariv ... K R Oldenburg
J Pharm Sci 2001 May; 90(5)580-87.
Score: 0.365
A reader's guide to the evaluation of screening studies.
C Earle ... P C Hebert
Postgrad Med J 1996 Feb; 72(844)77-83.
Score: 0.364
Assay concordance between SPA and TR-FRET in high-throughput screening.
Oliver von Ahsen ... Karsten Parczyk
J Biomol Screen 2006 Sep; 11(6)606-16.
Score: 0.364
Abstract:

PMID- 17896936
OWN - NLM
STAT- In-Data-Review
DA - 20070927
PUBM- Print
IS - 1386-2073 (Print)
VI - 10
IP - 6
DP - 2007 Jul
TI - Design considerations for high-throughput screening and in vitro diagnostic
assays.
PG - 399-412
AB - This paper reviews the several different factors that must be considered during
the development of assays for high throughput screening (HTS) or in vitro
diagnostic (IVD) applications. The reader is introduced to the terminology used
in assay development as well as the statistical approaches for evaluating the
data. The review is intended to serve as a tutorial to biotechnology,
pharmaceutical and clinical professionals, the academic researcher, as well as a
guide for established investigators of HTS and IVD. This review is not a
comprehensive treatise in its scope or content, but is meant to introduce the
reader to key concepts of assay development. Elementary mathematical and
statistical tools for designing robust assays and data management are described.
While certain design concepts overlap HTS and IVDs, others are more pertinent to
one or the other topic. An overview of the regulatory requirements for IVDs is
included in the context of the United States Food and Drug Administration.
Quality concepts and high content screening are also briefly described. The
review does not focus upon any particular assay technology nor does it provide
detailed laboratory procedures on specific assays. The references cited are not
exhaustive, but meant to steer the reader toward a general status report of the
various technologies discussed. The information presented in this review is not
intended to replace the judgment of the experienced laboratory scientist.
However, this review should assist the scientific professional in executing well
designed assays and being aware of design considerations.
AD - Biosensors and Nanomaterials Department, Sandia National Laboratories,
Albuquerque, New Mexico 87185, USA. kachyut@sandia.gov.
FAU - Achyuthan, Komandoor E
AU - Achyuthan KE
FAU - Whitten, David G
AU - Whitten DG
LA - eng
PT - Journal Article
PL - Netherlands
TA - Comb Chem High Throughput Screen
JT - Combinatorial chemistry & high throughput screening
JID - 9810948
SB - IM
EDAT- 2007/09/28 09:00
MHDA- 2007/09/28 09:00
PST - ppublish
SO - Comb Chem High Throughput Screen. 2007 Jul;10(6):399-412.
Keywords extracted from the abstract: [ eliminated words list ]
Count Word
12.198 09
6.000 1386-2073
12.198 399-412
2.074 ab
1.836 academic
10.881 achyuthan
1.819 ad
0.852 administration
3.098 albuquerque
2.071 applications
1.964 approaches
0.462 article
3.741 assay
6.646 assays
2.428 assist
4.886 au
2.636 aware
3.573 biosensors
2.276 biotechnology
2.586 briefly
1.789 certain
3.092 chem
0.927 chemistry
3.012 cited
0.816 clinical
6.900 comb
2.988 combinatorial
2.195 comprehensive
6.436 concepts
4.752 considerations
Count Word
1.543 considered
3.074 content
2.090 context
1.573 da
1.723 data
1.965 david
0.718 department
2.891 described
3.898 design
1.856 designed
2.953 designing
2.154 detailed
2.725 development
2.246 dg
2.516 diagnostic
1.008 different
1.486 discussed
2.234 dp
0.597 drug
6.000 edat-
2.986 elementary
0.488 eng
1.652 established
2.222 evaluating
4.132 executing
3.345 exhaustive
2.046 experienced
0.813 factors
9.232 fau
2.061 focus
Count Word
1.468 food
1.326 general
0.684 gov
2.440 guide
3.644 high
3.130 high-throughput
10.119 hts
0.466 im
6.000 in-data-review
1.537 included
1.363 information
5.503 intended
2.844 introduce
2.126 introduced
2.546 investigators
2.076 ip
8.291 ivd
10.627 ivds
5.496 jid
0.466 journal
2.264 jt
2.854 judgment
2.423 jul
6.000 kachyut
2.155 ke
1.877 key
6.000 komandoor
1.320 la
2.006 laboratories
2.741 laboratory
Count Word
1.362 management
2.455 mathematical
7.014 meant
2.134 mexico
6.000 mhda-
0.902 more
1.732 must
4.606 nanomaterials
1.381 national
1.217 netherlands
3.379 nlm
0.926 other
2.000 others
2.606 overlap
2.456 overview
2.162 own
1.623 paper
1.752 particular
2.978 pertinent
1.912 pg
1.818 pharmaceutical
2.212 pl
6.000 pmid-
6.000 ppublish
1.455 presented
6.711 print
1.530 procedures
1.839 professional
2.424 professionals
1.496 provide
Count Word
3.365 pst
1.594 pt
6.000 pubm-
1.421 quality
8.704 reader
1.799 regulatory
2.757 replace
0.947 report
2.097 requirements
3.394 researcher
3.145 review
2.324 reviews
2.658 robust
8.869 sandia
2.278 sb
2.170 scientific
3.561 scientist
2.834 scope
4.919 screen
5.039 screening
2.209 serve
1.178 specific
5.932 stat-
0.575 states
3.672 statistical
1.426 status
3.680 steer
2.115 ta
2.472 technologies
1.696 technology
Count Word
2.483 terminology
10.556 throughput
2.559 ti
2.359 tools
2.907 topic
4.251 treatise
1.303 tutorial
0.576 united
0.963 usa
0.946 used
1.344 various
2.170 vi
2.232 vitro
8.478 whitten
RIC Statistics:
Extraction Method: Keyword Count with Lexical Variants Added
Eliminated words list: MedlinePlus List
Similarity Method: Weighted keyword count
Weighting Method: Term Frequency * Inverse Document Frequency
Database: Medline abstracts (1967 - Present)
Publication Type: All
Score Calculation Method: Cosine Similarity Method
Sort by: Score
Submission date and time: 11-5-2007, 7:3:0
Computation time: 00:00:09

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