RIC: Research Interest Comparator

Klaus Braut, Ph.D.
Affiliation: not provided
Email: not provided
Home Page: not provided
All Results | New This Year | Abstract | Selected Publications | RIC Statistics Results - NEW THIS MONTH:

No matching results
 Abstract:

PMID- 17896936
OWN - NLM
STAT- In-Data-Review
DA - 20070927
PUBM- Print
IS - 1386-2073 (Print)
VI - 10
IP - 6
DP - 2007 Jul
TI - Design considerations for high-throughput screening and in vitro diagnostic
assays.
PG - 399-412
AB - This paper reviews the several different factors that must be considered during
the development of assays for high throughput screening (HTS) or in vitro
diagnostic (IVD) applications. The reader is introduced to the terminology used
in assay development as well as the statistical approaches for evaluating the
data. The review is intended to serve as a tutorial to biotechnology,
pharmaceutical and clinical professionals, the academic researcher, as well as a
guide for established investigators of HTS and IVD. This review is not a
comprehensive treatise in its scope or content, but is meant to introduce the
reader to key concepts of assay development. Elementary mathematical and
statistical tools for designing robust assays and data management are described.
While certain design concepts overlap HTS and IVDs, others are more pertinent to
one or the other topic. An overview of the regulatory requirements for IVDs is
included in the context of the United States Food and Drug Administration.
Quality concepts and high content screening are also briefly described. The
review does not focus upon any particular assay technology nor does it provide
detailed laboratory procedures on specific assays. The references cited are not
exhaustive, but meant to steer the reader toward a general status report of the
various technologies discussed. The information presented in this review is not
intended to replace the judgment of the experienced laboratory scientist.
However, this review should assist the scientific professional in executing well
designed assays and being aware of design considerations.
AD - Biosensors and Nanomaterials Department, Sandia National Laboratories,
Albuquerque, New Mexico 87185, USA. kachyut@sandia.gov.
FAU - Achyuthan, Komandoor E
AU - Achyuthan KE
FAU - Whitten, David G
AU - Whitten DG
LA - eng
PT - Journal Article
PL - Netherlands
TA - Comb Chem High Throughput Screen
JT - Combinatorial chemistry & high throughput screening
JID - 9810948
SB - IM
EDAT- 2007/09/28 09:00
MHDA- 2007/09/28 09:00
PST - ppublish
SO - Comb Chem High Throughput Screen. 2007 Jul;10(6):399-412.
Keywords extracted from the abstract: [ eliminated words list ]
Count Word
12.198 09
6.000 1386-2073
12.198 399-412
2.074 ab
1.836 academic
10.881 achyuthan
1.819 ad
0.852 administration
3.098 albuquerque
2.071 applications
1.964 approaches
0.462 article
3.741 assay
6.646 assays
2.428 assist
4.886 au
2.636 aware
3.573 biosensors
2.276 biotechnology
2.586 briefly
1.789 certain
3.092 chem
0.927 chemistry
3.012 cited
0.816 clinical
6.900 comb
2.988 combinatorial
2.195 comprehensive
6.436 concepts
4.752 considerations
Count Word
1.543 considered
3.074 content
2.090 context
1.573 da
1.723 data
1.965 david
0.718 department
2.891 described
3.898 design
1.856 designed
2.953 designing
2.154 detailed
2.725 development
2.246 dg
2.516 diagnostic
1.008 different
1.486 discussed
2.234 dp
0.597 drug
6.000 edat-
2.986 elementary
0.488 eng
1.652 established
2.222 evaluating
4.132 executing
3.345 exhaustive
2.046 experienced
0.813 factors
9.232 fau
2.061 focus
Count Word
1.468 food
1.326 general
0.684 gov
2.440 guide
3.644 high
3.130 high-throughput
10.119 hts
0.466 im
6.000 in-data-review
1.537 included
1.363 information
5.503 intended
2.844 introduce
2.126 introduced
2.546 investigators
2.076 ip
8.291 ivd
10.627 ivds
5.496 jid
0.466 journal
2.264 jt
2.854 judgment
2.423 jul
6.000 kachyut
2.155 ke
1.877 key
6.000 komandoor
1.320 la
2.006 laboratories
2.741 laboratory
Count Word
1.362 management
2.455 mathematical
7.014 meant
2.134 mexico
6.000 mhda-
0.902 more
1.732 must
4.606 nanomaterials
1.381 national
1.217 netherlands
3.379 nlm
0.926 other
2.000 others
2.606 overlap
2.456 overview
2.162 own
1.623 paper
1.752 particular
2.978 pertinent
1.912 pg
1.818 pharmaceutical
2.212 pl
6.000 pmid-
6.000 ppublish
1.455 presented
6.711 print
1.530 procedures
1.839 professional
2.424 professionals
1.496 provide
Count Word
3.365 pst
1.594 pt
6.000 pubm-
1.421 quality
8.704 reader
1.799 regulatory
2.757 replace
0.947 report
2.097 requirements
3.394 researcher
3.145 review
2.324 reviews
2.658 robust
8.869 sandia
2.278 sb
2.170 scientific
3.561 scientist
2.834 scope
4.919 screen
5.039 screening
2.209 serve
1.178 specific
5.932 stat-
0.575 states
3.672 statistical
1.426 status
3.680 steer
2.115 ta
2.472 technologies
1.696 technology
Count Word
2.483 terminology
10.556 throughput
2.559 ti
2.359 tools
2.907 topic
4.251 treatise
1.303 tutorial
0.576 united
0.963 usa
0.946 used
1.344 various
2.170 vi
2.232 vitro
8.478 whitten
RIC Statistics:
Extraction Method: Keyword Count with Lexical Variants Added
Eliminated words list: MedlinePlus List
Similarity Method: Weighted keyword count
Weighting Method: Term Frequency * Inverse Document Frequency
Database: Medline Updates from current month
Publication Type: All
Score Calculation Method: Cosine Similarity Method
Sort by: Score
Submission date and time: 11-5-2007, 7:3:0
Computation time: 00:00:09

For comments, suggestions, or complaints contact eTBLAST Support
A service of UT Southwestern eTBLAST team
Copyright © 2001 - 2007

Last updated: Monday, 05-Nov-2007 07:03:09 CST