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RIC: Research Interest Comparator
McEwan, William, Ph.D.
Affiliation: not provided
Email: not provided
Home Page: not provided
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RIC Statistics
Results - FULL MEDLINE:
Retrovirus restriction by TRIM5alpha variants from Old World and New World primates.
Byeongwoon Song ... Joseph Sodroski
J Virol 2005 Apr; 79(7)3930-7.
Score: 1.162
Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles.
Laura M J Ylinen ... Greg J Towers
J Virol 2005 Sep; 79(18)11580-7.
Score: 1.071
Trim5alpha protein restricts both HIV-1 and murine leukemia virus.
Melvyn W Yap ... Jonathan P Stoye
Proc Natl Acad Sci U S A 2004 Jul; 101(29)10786-91.
Score: 1.017
Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha.
Theodora Hatziioannou ... Paul D Bieniasz
Proc Natl Acad Sci U S A 2004 Jul; 101(29)10774-9.
Score: 0.993
TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells.
Michel J Perron ... Joseph Sodroski
Proc Natl Acad Sci U S A 2004 Aug; 101(32)11827-32.
Score: 0.983
Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain.
Sara L Sawyer ... Harmit S Malik
Proc Natl Acad Sci U S A 2005 Feb; 102(8)2832-7.
Score: 0.959
Adaptive evolution of primate TRIM5alpha, a gene restricting HIV-1 infection.
Hong-Liang Liu ... Bing Su
Gene 2005 Dec; 362()109-16.
Score: 0.958
Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction.
Matthew Stremlau ... Joseph Sodroski
J Virol 2005 Mar; 79(5)3139-45.
Score: 0.886
The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid.
Michel J Perron ... Joseph Sodroski
J Virol 2007 Mar; 81(5)2138-48.
Score: 0.881
Two surface-exposed elements of the B30.2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5alpha.
Michel J Perron ... Joseph Sodroski
J Virol 2006 Jun; 80(11)5631-6.
Score: 0.874
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor.
Matthew Stremlau ... Joseph Sodroski
Proc Natl Acad Sci U S A 2006 Apr; 103(14)5514-9.
Score: 0.863
Retroviral restriction factor TRIM5alpha is a trimer.
Claudia C Mische ... Joseph Sodroski
J Virol 2005 Nov; 79(22)14446-50.
Score: 0.841
Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity.
Zuzana Keckesova ... Greg J Towers
J Virol 2006 May; 80(10)4683-90.
Score: 0.831
In defense of the cell: TRIM5alpha interception of mammalian retroviruses.
Kyeongeun Lee ... Vineet N KewalRamani
Proc Natl Acad Sci U S A 2004 Jul; 101(29)10496-7.
Score: 0.830
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.
Byeongwoon Song ... Joseph Sodroski
J Virol 2005 May; 79(10)6111-21.
Score: 0.826
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.
Ruchi M Newman ... Welkin E Johnson
Proc Natl Acad Sci U S A 2006 Dec; 103(50)19134-9.
Score: 0.800
Control of viral infectivity by tripartite motif proteins.
Greg J Towers
Hum Gene Ther 2005 Oct; 16(10)1125-32.
Score: 0.790
The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase.
Neeltje A Kootstra ... Hanneke Schuitemaker
AIDS 2007 Oct; 21(15)2015-23.
Score: 0.782
Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells.
Elena Sokolskaja ... Jeremy Luban
J Virol 2006 Mar; 80(6)2855-62.
Score: 0.779
Isolation of an active Lv1 gene from cattle indicates that tripartite motif protein-mediated innate immunity to retroviral infection is widespread among mammals.
Laura M J Ylinen ... Greg J Towers
J Virol 2006 Aug; 80(15)7332-8.
Score: 0.764
Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues.
Lionel Berthoux ... Jeremy Luban
J Virol 2005 Jun; 79(12)7883-8.
Score: 0.763
TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activity.
Byeongwoon Song ... Joseph Sodroski
Virology 2005 Dec; 343(2)201-11.
Score: 0.761
A retrovirus restriction factor TRIM5alpha is transcriptionally regulated by interferons.
Kentaro Asaoka ... Satoshi Inoue
Biochem Biophys Res Commun 2005 Dec; 338(4)1950-6.
Score: 0.758
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
Matthew Stremlau ... Joseph Sodroski
Nature 2004 Feb; 427(6977)848-53.
Score: 0.755
Role of common human TRIM5alpha variants in HIV-1 disease progression.
Valérie Goldschmidt ... Amalio Telenti
Retrovirology 2006 ; 3()54.
Score: 0.755
Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding.
Hassan Javanbakht ... Joseph Sodroski
Virology 2006 Sep; 353(1)234-46.
Score: 0.751
Inhibition of HIV-1 replication by simian restriction factors, TRIM5alpha and APOBEC3G.
R Sakuma ... Y Ikeda
Gene Ther 2007 Jan; 14(2)185-9.
Score: 0.733
Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1.
Matthew Stremlau ... Joseph Sodroski
Virology 2006 Jul; 351(1)112-20.
Score: 0.732
Restriction of multiple divergent retroviruses by Lv1 and Ref1.
Theodora Hatziioannou ... Greg J Towers
EMBO J 2003 Feb; 22(3)385-94.
Score: 0.726
A dominant-negative effect of cynomolgus monkey tripartite motif protein TRIM5alpha on anti-simian immunodeficiency virus SIVmac activity of an African green monkey orthologue.
Emi E Nakayama ... Tatsuo Shioda
Virology 2006 Jun; 350(1)158-63.
Score: 0.717
How TRIM5alpha defends against retroviral invasions.
Michael Emerman
Proc Natl Acad Sci U S A 2006 Apr; 103(14)5249-50.
Score: 0.714
Unique features of TRIM5alpha among closely related human TRIM family members.
Xing Li ... Joseph Sodroski
Virology 2007 Apr; 360(2)419-33.
Score: 0.713
Human TRIM5alpha mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants.
Patrick Kaumanns ... Matthias T Dittmar
Retrovirology 2006 ; 3()79.
Score: 0.706
High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.
Sara L Sawyer ... Harmit S Malik
Curr Biol 2006 Jan; 16(1)95-100.
Score: 0.699
A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction.
Melvyn W Yap ... Jonathan P Stoye
Curr Biol 2005 Jan; 15(1)73-8.
Score: 0.698
Relatedness among contractile and membrane proteins: evidence for evolution from common ancestral genes.
J K Weltman ... R M Dowben
Proc Natl Acad Sci U S A 1973 Nov; 70(11)3230-4.
Score: 0.696
Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins.
Dyana T Saenz ... Eric M Poeschla
J Virol 2005 Dec; 79(24)15175-88.
Score: 0.695
[TRIM5alpha]
Emi E Nakayama ... Tatsuo Shioda
Uirusu 2005 Dec; 55(2)259-65.
Score: 0.694
Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein.
Shari M Kaiser ... Michael Emerman
Science 2007 Jun; 316(5832)1756-8.
Score: 0.693
Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.
Hassan Javanbakht ... Cheryl Winkler
Virology 2006 Oct; 354(1)15-27.
Score: 0.692
The control of viral infection by tripartite motif proteins and cyclophilin A.
Greg J Towers
Retrovirology 2007 ; 4()40.
Score: 0.688
TRIM5alpharh expression restricts HIV-1 infection in lentiviral vector-transduced CD34+-cell-derived macrophages.
Joseph Anderson ... Ramesh Akkina
Mol Ther 2005 Oct; 12(4)687-96.
Score: 0.687
Methylation of Herpesvirus saimiri DNA in lymphoid tumor cell lines.
R C Desrosiers ... B Fleckenstein
Proc Natl Acad Sci U S A 1979 Aug; 76(8)3839-43.
Score: 0.686
Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection.
Yuan Li ... Joseph Sodroski
J Virol 2006 Jul; 80(14)6738-44.
Score: 0.683
Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection.
Xiaolu Wu ... Thomas J Hope
Proc Natl Acad Sci U S A 2006 May; 103(19)7465-70.
Score: 0.682
Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins.
Jenny L Anderson ... Thomas J Hope
J Virol 2006 Oct; 80(19)9754-60.
Score: 0.677
Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells.
Lionel Berthoux ... Jeremy Luban
Proc Natl Acad Sci U S A 2005 Oct; 102(41)14849-53.
Score: 0.673
All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction.
Sadayuki Ohkura ... Jonathan P Stoye
J Virol 2006 Sep; 80(17)8554-65.
Score: 0.661
Trim5alpha accelerates degradation of cytosolic capsid associated with productive HIV-1 entry.
Udayan Chatterji ... Philippe A Gallay
J Biol Chem 2006 Dec; 281(48)37025-33.
Score: 0.661
A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines species-specific restriction of simian immunodeficiency virus SIVmac infection.
Emi E Nakayama ... Tatsuo Shioda
J Virol 2005 Jul; 79(14)8870-7.
Score: 0.660
The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities.
Zuzana Keckesova ... Greg J Towers
Proc Natl Acad Sci U S A 2004 Jul; 101(29)10780-5.
Score: 0.654
A brief history of TRIM5alpha.
Ruchi M Newman ... Welkin E Johnson
AIDS Rev 2007 Apr-Jun; 9(2)114-25.
Score: 0.652
Functional interplay between the B-box 2 and the B30.2(SPRY) domains of TRIM5alpha.
Xing Li ... Joseph Sodroski
Virology 2007 Sep; 366(2)234-44.
Score: 0.650
Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.
Emily C Speelmon ... M Juliana McElrath
J Virol 2006 Mar; 80(5)2463-71.
Score: 0.650
Modulation of Retroviral Restriction and Proteasome Inhibitor-Resistant Turnover by Changes in the TRIM5{alpha} B-Box 2 Domain.
Felipe Diaz-Griffero ... Joseph Sodroski
J Virol 2007 Oct; 81(19)10362-78.
Score: 0.640
Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5.
Felipe Diaz-Griffero ... Joseph Sodroski
Virology 2006 Jun; 349(2)300-15.
Score: 0.634
The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5alpha.
Hassan Javanbakht ... Joseph Sodroski
J Biol Chem 2005 Jul; 280(29)26933-40.
Score: 0.623
Wild type and H43Y variant of human TRIM5alpha show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro.
Emi E Nakayama ... Ioannis Theodorou
Immunogenetics 2007 Jun; 59(6)511-5.
Score: 0.622
The design of artificial retroviral restriction factors.
Melvyn W Yap ... Jonathan P Stoye
Virology 2007 Sep; 365(2)302-14.
Score: 0.620
Patterns of evolution of host proteins involved in retroviral pathogenesis.
Millan Ortiz ... Amalio Telenti
Retrovirology 2006 ; 3()11.
Score: 0.611
Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.
Xing Li ... Joseph Sodroski
J Virol 2006 Jul; 80(13)6198-206.
Score: 0.607
Cellular restriction factors affecting the early stages of HIV replication.
Omar Perez ... Thomas J Hope
Curr HIV/AIDS Rep 2006 Feb; 3(1)20-5.
Score: 0.605
Rhesus monkey TRIM5alpha restricts HIV-1 production through rapid degradation of viral Gag polyproteins.
Ryuta Sakuma ... Yasuhiro Ikeda
Nat Med 2007 May; 13(5)631-5.
Score: 0.601
Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity.
David Perez-Caballero ... Paul D Bieniasz
J Virol 2005 Jul; 79(14)8969-78.
Score: 0.599
An active TRIM5 protein in rabbits indicates a common antiviral ancestor for mammalian TRIM5 proteins.
Torsten Schaller ... Greg J Towers
J Virol 2007 Nov; 81(21)11713-21.
Score: 0.594
Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria.
R H Adamson ... R T Williams
Biochem J 1970 Feb; 116(3)437-43.
Score: 0.588
Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.
Luca D Passerini ... Greg J Towers
J Virol 2006 Mar; 80(5)2100-5.
Score: 0.585
Evolutionary implications of primate endogenous retroviruses.
A Shih ... M G Rush
Virology 1991 Jun; 182(2)495-502.
Score: 0.578
TRIM5alpha selectively binds a restriction-sensitive retroviral capsid.
Sarah Sebastian ... Jeremy Luban
Retrovirology 2005 ; 2()40.
Score: 0.561
Alpha Interferon Enhances TRIM5{alpha}-Mediated Antiviral Activities in Human and Rhesus Monkey Cells.
Ryuta Sakuma ... Yasuhiro Ikeda
J Virol 2007 Sep; 81(18)10201-6.
Score: 0.554
Assessing the accuracy of ancestral protein reconstruction methods.
Paul D Williams ... Richard A Goldstein
PLoS Comput Biol 2006 Jun; 2(6)e69.
Score: 0.553
A Single Amino Acid of the Human Immunodeficiency Virus Type 2 Capsid Affects Its Replication in the Presence of Cynomolgus Monkey and Human TRIM5{alpha}s.
Haihan Song ... Tatsuo Shioda
J Virol 2007 Jul; 81(13)7280-5.
Score: 0.551
Antiretroviral potential of human tripartite motif-5 and related proteins.
Fengwen Zhang ... Paul D Bieniasz
Virology 2006 Sep; 353(2)396-409.
Score: 0.551
Ancestral population sizes and species divergence times in the primate lineage on the basis of intron and BAC end sequences.
Yoko Satta ... Jan Klein
J Mol Evol 2004 Oct; 59(4)478-87.
Score: 0.550
Retroviruses 3.
Curr Top Microbiol Immunol 1984 ; 112()1-115.
Score: 0.546
Mason-Pfizer virus characterization: a similar virus in a human amniotic cell line.
W P Parks ... E M Scolnick
J Virol 1973 Dec; 12(6)1540-7.
Score: 0.532
Structural comparison of the external glycoproteins of human and simian immunodeficiency virus.
W Lüke ... G Hunsmann
Intervirology 1991 ; 32(3)198-203.
Score: 0.530
Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill.
H Tsujimoto ... M Hayami
Nature 1989 Oct; 341(6242)539-41.
Score: 0.522
Fusion of cyclophilin a to fv1 enables cyclosporine-sensitive restriction of human and feline immunodeficiency viruses.
Torsten Schaller ... Greg J Towers
J Virol 2007 Sep; 81(18)10055-63.
Score: 0.516
Genetic diversity of simian immunodeficiency virus.
Y Li ... R C Desrosiers
J Med Primatol 1989 ; 18(3-4)261-9.
Score: 0.514
The Retroviral Restriction Factor TRIM5alpha.
Sarah Sebastian ... Jeremy Luban
Curr Infect Dis Rep 2007 Mar; 9(2)167-73.
Score: 0.506
A TRIM5alpha-independent post-entry restriction to HIV-1 infection of macaque cells that is dependent on the path of entry.
Mario Javier Pineda ... Julie Overbaugh
Virology 2007 Jul; 363(2)310-8.
Score: 0.501
Simian immunodeficiency virus from African green monkeys.
M D Daniel ... P K Sehgal
J Virol 1988 Nov; 62(11)4123-8.
Score: 0.500
Reconstruction of ancestral protein sequences and its applications.
Wei Cai ... Nick V Grishin
BMC Evol Biol 2004 Sep; 4()33.
Score: 0.494
Phylogeny and natural history of the primate lentiviruses, SIV and HIV.
V M Hirsch ... B J Campbell
Curr Opin Genet Dev 1995 Dec; 5(6)798-806.
Score: 0.492
Adaptive origins of primates revisited.
Christophe Soligo ... Robert D Martin
J Hum Evol 2006 Apr; 50(4)414-30.
Score: 0.490
Functional analysis of long terminal repeats derived from four strains of simian immunodeficiency virus SIVAGM in relation to other primate lentiviruses.
J Sakuragi ... A Adachi
Virology 1991 Nov; 185(1)455-9.
Score: 0.489
Evolution of the primate lineage leading to modern humans: phylogenetic and demographic inferences from DNA sequences.
N Takahata ... Y Satta
Proc Natl Acad Sci U S A 1997 Apr; 94(9)4811-5.
Score: 0.485
Extensive genetic variability of simian immunodeficiency virus from African green monkeys.
Y Li ... R C Desrosiers
J Virol 1989 Apr; 63(4)1800-2.
Score: 0.482
Isolation and characterization of simian immunodeficiency virus variants that are resistant to nonnucleoside reverse transcriptase inhibitors.
Y Isaka ... A Sato
Arch Virol 2000 ; 145(12)2481-92.
Score: 0.481
Ancestral sequence reconstruction in primate mitochondrial DNA: compositional bias and effect on functional inference.
Neeraja M Krishnan ... David D Pollock
Mol Biol Evol 2004 Oct; 21(10)1871-83.
Score: 0.480
Ancestral odontology.
Lancet 1990 Sep; 336(8716)661-2.
Score: 0.477
Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection.
Zhihai Si ... Joseph Sodroski
Proc Natl Acad Sci U S A 2006 May; 103(19)7454-9.
Score: 0.473
A single amino acid change at Leu-188 in the reverse transcriptase of HIV-2 and SIV renders them sensitive to non-nucleoside reverse transcriptase inhibitors.
Y Isaka ... A Sato
Arch Virol 2001 ; 146(4)743-55.
Score: 0.469
Ancestral facial morphology of Old World higher primates.
B R Benefit ... M L McCrossin
Proc Natl Acad Sci U S A 1991 Jun; 88(12)5267-71.
Score: 0.469
Arsenic counteracts human immunodeficiency virus type 1 restriction by various TRIM5 orthologues in a cell type-dependent manner.
Sarah Sebastian ... Jeremy Luban
J Virol 2006 Feb; 80(4)2051-4.
Score: 0.468
Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism.
Simone Cowan ... Paul D Bieniasz
Proc Natl Acad Sci U S A 2002 Sep; 99(18)11914-9.
Score: 0.467
Human chromosome 16 conservation in primates.
Doriana Misceo ... Nicoletta Archidiacono
Chromosome Res 2003 ; 11(4)323-6.
Score: 0.464
Revertants of adenovirus type 12-transformed hamster cell line T637 as tools in the analysis of integration patterns.
D Eick ... W Doerfler
J Virol 1980 Oct; 36(1)41-9.
Score: 0.463
Accelerated evolution and loss of a domain of the sperm-egg-binding protein SED1 in ancestral primates.
Ondrej Podlaha ... Jianzhi Zhang
Mol Biol Evol 2006 Oct; 23(10)1828-31.
Score: 0.463
Abstract:
The antiretroviral protein TRIM5alpha is known to have evolved different restriction capacities against various retroviruses, driven by positive Darwinian selection. However, how these different specificities have evolved in the primate lineages is not fully understood. Here we used ancestral protein resurrection to estimate the evolution of antiviral restriction specificities of TRIM5alpha on the primate lineage leading to humans. We used TRIM5alpha coding sequences from 24 primates for the reconstruction of ancestral TRIM5alpha sequences using maximum likelihood and Bayesian approaches. Ancestral sequences were transduced into HeLa and CRFK cells. Stable cell lines were generated and used to test restriction of a panel of extant retroviruses (HIV-1, HIV-2, SIVmac, SIVagm, N-MLV and B-MLV). The resurrected TRIM5alpha variant from the common ancestor of Old World primates (Old World monkeys and apes, approximately 25 million years before present) was effective against modern/current day HIV-1. Contrary to the HIV-1 restriction pattern, we show that restriction efficacy against other retroviruses, such as a murine oncoretrovirus (N-MLV), is higher for more recent resurrected hominoid variants. Ancestral TRIM5alpha variants have generally limited efficacy against HIV-2, SIVagm, and SIVmac.. Our study sheds new light on the evolution of the intrinsic antiviral defense machinery and illustrates the utility of functional evolutionary reconstruction for characterizing recently emerged protein differences.
Keywords extracted from the abstract:
[ eliminated words list ]
Count
Word
3.247
ancestor
9.930
ancestral
2.616
antiretroviral
4.314
antiviral
3.718
apes
1.964
approaches
1.454
approximately
6.000
b-mlv
3.145
bayesian
2.915
capacities
0.664
cell
0.616
cells
2.900
characterizing
2.118
coding
1.376
common
2.472
contrary
4.548
crfk
1.462
current
4.110
darwinian
1.280
day
2.348
defense
1.256
differences
2.050
different
2.624
driven
1.396
effective
3.259
efficacy
2.575
emerged
2.105
estimate
3.676
evolution
2.386
evolutionary
Count
Word
5.369
evolved
3.448
extant
2.043
fully
1.367
functional
1.884
generally
1.856
generated
2.187
hela
1.114
higher
5.222
hiv-1
6.227
hiv-2
4.185
hominoid
1.848
humans
2.836
illustrates
2.191
intrinsic
1.431
known
1.912
leading
1.529
light
2.400
likelihood
1.723
limited
2.476
lineage
2.783
lineages
1.587
lines
2.761
machinery
1.701
maximum
2.356
million
2.138
modern
2.223
monkeys
0.902
more
1.819
murine
12.198
n-mlv
Count
Word
3.614
old
5.455
oncoretrovirus
0.926
other
2.378
panel
1.475
pattern
1.295
positive
5.384
primate
5.337
primates
1.910
protein
1.555
recent
1.689
recently
4.161
reconstruction
6.479
restriction
10.004
resurrected
4.430
resurrection
8.035
retroviruses
1.731
selection
4.181
sequences
3.953
sheds
8.878
sivagm
8.305
sivmac
5.503
specificities
1.734
stable
2.916
transduced
23.500
trim5alpha
2.259
understood
2.578
used
0.886
using
2.333
utility
2.078
variant
Count
Word
4.302
variants
1.344
various
3.824
world
1.053
years
RIC Statistics:
Extraction Method: Keyword Count with Lexical Variants Added
Eliminated words list: MedlinePlus List
Similarity Method: Weighted keyword count
Weighting Method: Term Frequency * Inverse Document Frequency
Database: Medline abstracts (1967 - Present)
Publication Type: All
Score Calculation Method: Cosine Similarity Method
Sort by: Score
Submission date and time: 1-30-2008, 10:27:3
Computation time: 00:00:13
Last updated: Wednesday, 30-Jan-2008 10:27:16 CST