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RIC: Research Interest Comparator |
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PI
Affiliation: Cell Biology
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Email: knop@embl.de
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Organisms have developed survival strategies in response to environmental changes. Yeast cells undergo meiotic differentiation into resistant spores. Upon improving conditions the spores germinate and mate with partners within the same ascus. Here we report a novel regulation of the mating process that enhances survival of a small population. The molecular mechanism is based on spindle pole body inheritance and the linkage of the mating type locus to the centromere. It optimizes intra-ascal mating and allows maximal transmission of heterozygousity of centromere linked chromosomal regions, which contain a high proportion of essential genes. We report a correlation with genome evolution of modern yeast species of the 'sensu stricto' S. cerevisiae group. A model that outlines the driving force leading to the current genome organization and sexual life style of yeast is described.
Extraction Method: Keyword Count with Lexical Variants Added-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted Keyword Count
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Weighting Method: Term Frequency * Inverse Document Frequency
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Database: Medline Updates from current month
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Results computed on: 6/9/2006