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RIC: Research Interest Comparator |
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Dr.
Affiliation: GBF mbh
Office: not provided
Phone #: +49-531-6181-687
Fax: +49-531-6181-444
Email: wmueller@gbf.de
Home Page: http://www.gbf.de/ei/
Lab: not provided
Date: 2004-12-17 09:48:56 +0100
Topic: Abstract
Interleukin (IL)-10 is a regulator of inflammatory responses and is secreted by a variety of different cell types including T cells. T regulatory cells have been shown to suppress immune responses by IL-10-dependent, but also IL-10-independent, mechanisms. Herein, we address the role of T cell-derived IL-10 in mice with an inactivation of the IL-10 gene restricted to T cells generated by Cre/loxP-mediated targeting of the IL-10 gene. Splenocytes from this T cell-specific mutant secrete increased amounts of proinflammatory cytokines after activation in vitro compared with show enhanced contact hypersensitivity reactions, and succumb to severe immunopathology upon infection with Toxoplasma gondii. Despite intact IL-10 genes in other cell types, the dysregulation of T cell responses observed in the T cell-specific IL-10 mutant closely resembles the phenotype in complete IL-10 deficiency. However, in contrast to complete IL-10 deficiency, sensitivity to endotoxic shock and irritant responses of the skin are not enhanced in the T cell-specific IL-10 mutant. Our data highlight the importance of T cell-derived IL-10 in the regulation of T cell responses and demonstrate that endotoxic shock and the irritant response of the skin are controlled by IL-10 from other cell types.
Extraction Method: Keyword Count with Lexical Variants Added-
Eliminated words list: MedlinePlus List
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Similarity Method: Weighted Keyword Count
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Weighting Method: Term Frequency * Inverse Document Frequency
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Database: Medline Updates from current month
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Publication Type: All
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Score Calculation Method: Cosine Similarity Method
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Sort by: Score
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Results computed on: 6/9/2006