[Involvement of unfolded protein responses in neurodegeneration]
- Takashi Kudo
- Nihon Shinkei Seishin Yakurigaku Zasshi 2003 Jun; 23(3)105-9.
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Score: 0.988 |
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The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum.
- Xiaohua Shen ... Randal J Kaufman
- J Chem Neuroanat 2004 Sep; 28(1-2)79-92.
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Score: 0.976 |
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The unfolded protein response is involved in the pathology of Alzheimer's disease.
- Takashi Kudo ... Masatoshi Takeda
- Ann N Y Acad Sci 2002 Nov; 977()349-55.
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Score: 0.974 |
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The physiological unfolded protein response in the thyroid epithelial cells.
- Ernest Sargsyan ... Souren Mkrtchian
- Biochem Biophys Res Commun 2004 Sep; 322(2)570-6.
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Score: 0.963 |
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From acute ER stress to physiological roles of the Unfolded Protein Response.
- J Wu ... R J Kaufman
- Cell Death Differ 2006 Mar; 13(3)374-84.
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Score: 0.913 |
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Cerebral ischemia and the unfolded protein response.
- Donald J DeGracia ... Heather L Montie
- J Neurochem 2004 Oct; 91(1)1-8.
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Score: 0.910 |
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Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum.
- Satomi Nadanaka ... Kazutoshi Mori
- Mol Biol Cell 2004 Jun; 15(6)2537-48.
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Score: 0.904 |
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The unfolded protein response: a stress signaling pathway critical for health and disease.
- Kezhong Zhang ... Randal J Kaufman
- Neurology 2006 Jan; 66(2 Suppl 1)S102-9.
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Score: 0.892 |
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The mammalian unfolded protein response.
- Martin Schröder ... Randal J Kaufman
- Annu Rev Biochem 2005 ; 74()739-89.
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Score: 0.886 |
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ER stress signaling by regulated splicing: IRE1/HAC1/XBP1.
- Sung Hoon Back ... Randal J Kaufman
- Methods 2005 Apr; 35(4)395-416.
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Score: 0.875 |
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ER stress and the unfolded protein response.
- Martin Schröder ... Randal J Kaufman
- Mutat Res 2005 Jan; 569(1-2)29-63.
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Score: 0.873 |
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Protein folding in the endoplasmic reticulum and the unfolded protein response.
- K Zhang ... R J Kaufman
- Handb Exp Pharmacol 2006 ; (172)69-91.
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Score: 0.870 |
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On the mechanism of sensing unfolded protein in the endoplasmic reticulum.
- Joel J Credle ... Peter Walter
- Proc Natl Acad Sci U S A 2005 Dec; 102(52)18773-84.
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Score: 0.866 |
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Divergent roles of IRE1alpha and PERK in the unfolded protein response.
- Martin Schröder ... Randal J Kaufman
- Curr Mol Med 2006 Feb; 6(1)5-36.
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Score: 0.865 |
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PERK mediates cell-cycle exit during the mammalian unfolded protein response.
- J W Brewer ... J A Diehl
- Proc Natl Acad Sci U S A 2000 Nov; 97(23)12625-30.
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Score: 0.862 |
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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation.
- K J Travers ... P Walter
- Cell 2000 Apr; 101(3)249-58.
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Score: 0.852 |
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FAD-linked presenilin-1 mutants impede translation regulation under ER stress.
- Yuka Yasuda ... Masatoshi Takeda
- Biochem Biophys Res Commun 2002 Aug; 296(2)313-8.
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Score: 0.849 |
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The cargo receptor ERGIC-53 is a target of the unfolded protein response.
- Beat Nyfeler ... Hans-Peter Hauri
- Biochem Biophys Res Commun 2003 May; 304(4)599-604.
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Score: 0.848 |
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A trip to the ER: coping with stress.
- D Thomas Rutkowski ... Randal J Kaufman
- Trends Cell Biol 2004 Jan; 14(1)20-8.
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Score: 0.845 |
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Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
- X Shen ... R J Kaufman
- Cell 2001 Dec; 107(7)893-903.
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Score: 0.845 |
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Evidence for the intimate relationship between vesicle budding from the ER and the unfolded protein response.
- Miyuki Sato ... Akihiko Nakano
- Biochem Biophys Res Commun 2002 Aug; 296(3)560-7.
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Score: 0.843 |
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Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.
- C Y Liu ... R J Kaufman
- J Biol Chem 2000 Aug; 275(32)24881-5.
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Score: 0.840 |
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Endoplasmic reticulum dysfunction in brain pathology: critical role of protein synthesis.
- Wulf Paschen
- Curr Neurovasc Res 2004 Apr; 1(2)173-81.
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Score: 0.836 |
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
- Marcella Calfon ... David Ron
- Nature 2002 Jan; 415(6867)92-6.
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Score: 0.815 |
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Rapid activation of glycogen phosphorylase by the endoplasmic reticulum unfolded protein response.
- Arvind Gill ... Mark A Lehrman
- J Biol Chem 2002 Nov; 277(47)44747-53.
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Score: 0.814 |
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Activation of an unfolded protein response during differentiation of antibody-secreting B cells.
- Jennifer N Gass ... Joseph W Brewer
- J Biol Chem 2002 Dec; 277(50)49047-54.
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Score: 0.802 |
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[The regulation of unfolded protein response by OASIS, a transmembrane bZIP transcription factor, in astrocytes]
- Kazunori Imaizumi ... Masaya Tohyama
- Nippon Yakurigaku Zasshi 2004 Dec; 124(6)383-90.
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Score: 0.799 |
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JAB1 participates in unfolded protein responses by association and dissociation with IRE1.
- Kayoko Oono ... Masaya Tohyama
- Neurochem Int 2004 Oct; 45(5)765-72.
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Score: 0.797 |
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Dysfunction of the unfolded protein response during global brain ischemia and reperfusion.
- Rita Kumar ... Donald J DeGracia
- J Cereb Blood Flow Metab 2003 Apr; 23(4)462-71.
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Score: 0.787 |
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Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.
- Yukio Kimata ... Kenji Kohno
- Mol Biol Cell 2003 Jun; 14(6)2559-69.
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Score: 0.784 |
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Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.
- C E Shamu ... P Walter
- EMBO J 1996 Jun; 15(12)3028-39.
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Score: 0.784 |
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Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin.
- Uma Kant Misra ... Salvatore Vincent Pizzo
- J Leukoc Biol 2005 Jul; 78(1)187-94.
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Score: 0.784 |
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Transcriptional and translational control in the Mammalian unfolded protein response.
- Heather P Harding ... David Ron
- Annu Rev Cell Dev Biol 2002 ; 18()575-99.
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Score: 0.782 |
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ER chaperone functions during normal and stress conditions.
- Yanjun Ma ... Linda M Hendershot
- J Chem Neuroanat 2004 Sep; 28(1-2)51-65.
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Score: 0.782 |
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Unfolded protein response followed by induction of cell death in cultured tobacco cells treated with tunicamycin.
- Yuji Iwata ... Nozomu Koizumi
- Planta 2005 Mar; 220(5)804-7.
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Score: 0.778 |
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Endoplasmic reticulum signaling as a determinant of recombinant protein expression.
- Renata E Cudna ... Alan J Dickson
- Biotechnol Bioeng 2003 Jan; 81(1)56-65.
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Score: 0.777 |
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Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain.
- Wulf Paschen
- Cell Calcium 2003 Oct-Nov; 34(4-5)365-83.
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Score: 0.772 |
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XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.
- Rungtawan Sriburi ... Joseph W Brewer
- J Cell Biol 2004 Oct; 167(1)35-41.
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Score: 0.772 |
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The unfolded protein response and Alzheimer's disease.
- K Imaizumi ... M Tohyama
- Biochim Biophys Acta 2001 May; 1536(2-3)85-96.
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Score: 0.771 |
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Aspects of gene regulation during the UPR in human cells.
- C Benedetti ... A Cabibbo
- Biochem Biophys Res Commun 2000 Nov; 278(3)530-6.
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Score: 0.770 |
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Genomic analysis of the unfolded protein response in Arabidopsis shows its connection to important cellular processes.
- Immaculada M Martínez ... Maarten J Chrispeels
- Plant Cell 2003 Feb; 15(2)561-76.
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Score: 0.769 |
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ER stress response: getting the UPR hand on misfolded proteins.
- R Y Hampton
- Curr Biol 2000 Jul; 10(14)R518-21.
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Score: 0.765 |
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A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response.
- M Niwa ... P Walter
- Cell 1999 Dec; 99(7)691-702.
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Score: 0.763 |
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Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function.
- Charissa D Ellis ... David J Eide
- J Cell Biol 2004 Aug; 166(3)325-35.
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Score: 0.754 |
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A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.
- J S Cox ... P Walter
- Cell 1996 Nov; 87(3)391-404.
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Score: 0.753 |
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Cataracts: role of the unfolded protein response.
- Toshimichi Shinohara ... Michael L Mulhern
- Med Hypotheses 2006 ; 66(2)365-70.
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Score: 0.752 |
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ER signaling in unfolded protein response.
- Masayuki Kaneko ... Yasuyuki Nomura
- Life Sci 2003 Dec; 74(2-3)199-205.
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Score: 0.750 |
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Mif1: a missing link between the unfolded protein response pathway and ER-associated protein degradation?
- T van Laar ... C Terleth
- Curr Protein Pept Sci 2001 Jun; 2(2)169-90.
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Score: 0.748 |
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Enlargement of the endoplasmic reticulum membrane in Saccharomyces cerevisiae is not necessarily linked to the unfolded protein response via Ire1p.
- A K Stroobants ... H F Tabak
- FEBS Lett 1999 Jun; 453(1-2)210-4.
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Score: 0.747 |
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The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response.
- W Tirasophon ... R J Kaufman
- Genes Dev 2000 Nov; 14(21)2725-36.
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Score: 0.746 |
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Deletion of yeast p24 genes activates the unfolded protein response.
- W J Belden ... C Barlowe
- Mol Biol Cell 2001 Apr; 12(4)957-69.
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Score: 0.746 |
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The unfolded protein response regulates glutamate receptor export from the endoplasmic reticulum.
- Jaegal Shim ... Christopher Rongo
- Mol Biol Cell 2004 Nov; 15(11)4818-28.
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Score: 0.744 |
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Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways.
- Yanjun Ma ... Linda M Hendershot
- J Biol Chem 2004 Apr; 279(14)13792-9.
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Score: 0.740 |
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Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response.
- Christopher K Patil ... Peter Walter
- PLoS Biol 2004 Aug; 2(8)E246.
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Score: 0.736 |
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Regulation of the dolichol pathway in human fibroblasts by the endoplasmic reticulum unfolded protein response.
- W T Doerrler ... M A Lehrman
- Proc Natl Acad Sci U S A 1999 Nov; 96(23)13050-5.
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Score: 0.735 |
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Intracellular signaling from the endoplasmic reticulum to the nucleus.
- R Chapman ... P Walter
- Annu Rev Cell Dev Biol 1998 ; 14()459-85.
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Score: 0.734 |
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The unfolded protein response: a novel component of the hypoxic stress response in tumors.
- Douglas E Feldman ... Albert C Koong
- Mol Cancer Res 2005 Nov; 3(11)597-605.
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Score: 0.732 |
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Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha.
- Xin Xue ... Hiroyasu Nakano
- J Biol Chem 2005 Oct; 280(40)33917-25.
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Score: 0.731 |
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Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
- Xiaohua Shen ... Randal J Kaufman
- PLoS Genet 2005 Sep; 1(3)e37.
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Score: 0.728 |
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Induction of neuronal death by ER stress in Alzheimer's disease.
- Taiichi Katayama ... Masaya Tohyama
- J Chem Neuroanat 2004 Sep; 28(1-2)67-78.
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Score: 0.724 |
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Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
- T Katayama ... M Tohyama
- J Biol Chem 2001 Nov; 276(46)43446-54.
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Score: 0.722 |
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Endoplasmic reticulum stress response and neurodegeneration.
- Wulf Paschen ... Thorsten Mengesdorf
- Cell Calcium 2005 Sep-Oct; 38(3-4)409-15.
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Score: 0.721 |
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Autoregulation of the HAC1 gene is required for sustained activation of the yeast unfolded protein response.
- Naoki Ogawa ... Kazutoshi Mori
- Genes Cells 2004 Feb; 9(2)95-104.
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Score: 0.718 |
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Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins.
- Yukio Kimata ... Kenji Kohno
- Genes Cells 2006 Jan; 11(1)59-69.
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Score: 0.716 |
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OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes.
- Shinichi Kondo ... Kazunori Imaizumi
- Nat Cell Biol 2005 Feb; 7(2)186-94.
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Score: 0.716 |
|
A role for the unfolded protein response in optimizing antibody secretion.
- Kathryn E Gunn ... Joseph W Brewer
- Mol Immunol 2004 Jul; 41(9)919-27.
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Score: 0.709 |
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Extension of lipid-linked oligosaccharides is a high-priority aspect of the unfolded protein response: endoplasmic reticulum stress in Type I congenital disorder of glycosylation fibroblasts.
- Jie Shang ... Mark A Lehrman
- Glycobiology 2002 May; 12(5)307-17.
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Score: 0.708 |
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Role of the unfolded protein response pathway in secretory stress and regulation of INO1 expression in Saccharomyces cerevisiae.
- Hak J Chang ... Susan A Henry
- Genetics 2004 Dec; 168(4)1899-913.
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Score: 0.708 |
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Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.
- Tetsuya Okada ... Kazutoshi Mori
- Biochem J 2002 Sep; 366(Pt 2)585-94.
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Score: 0.707 |
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The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control.
- D T Ng ... P Walter
- J Cell Biol 2000 Jul; 150(1)77-88.
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Score: 0.707 |
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The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor.
- Monzy Thomas ... Andrew P Lieberman
- J Biol Chem 2005 Jun; 280(22)21264-71.
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Score: 0.707 |
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XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.
- Ann-Hwee Lee ... Laurie H Glimcher
- Mol Cell Biol 2003 Nov; 23(21)7448-59.
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Score: 0.706 |
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The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain.
- Chuan Yin Liu ... Randal J Kaufman
- J Biol Chem 2002 May; 277(21)18346-56.
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Score: 0.704 |
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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase.
- J S Cox ... P Walter
- Cell 1993 Jun; 73(6)1197-206.
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Score: 0.702 |
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Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals.
- C Patil ... P Walter
- Curr Opin Cell Biol 2001 Jun; 13(3)349-55.
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Score: 0.701 |
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The cellular response to protein misfolding in the endoplasmic reticulum.
- A A Welihinda ... R J Kaufman
- Gene Expr 1999 ; 7(4-6)293-300.
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Score: 0.699 |
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Characterization of mouse Ire1 alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell line.
- K Miyoshi ... M Tohyama
- Brain Res Mol Brain Res 2000 Dec; 85(1-2)68-76.
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Score: 0.697 |
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Endoplasmic reticulum stress and the making of a professional secretory cell.
- Eelco van Anken ... Ineke Braakman
- Crit Rev Biochem Mol Biol 2005 Sep-Oct; 40(5)269-83.
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Score: 0.695 |
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The unfolded protein response is activated in Alzheimer's disease.
- J J M Hoozemans ... W Scheper
- Acta Neuropathol (Berl) 2005 Aug; 110(2)165-72.
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Score: 0.694 |
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Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae.
- Yijun Chen ... Albert C Koong
- Mol Cancer Res 2005 Dec; 3(12)669-77.
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Score: 0.691 |
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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
- Kyungho Lee ... Randal J Kaufman
- Genes Dev 2002 Feb; 16(4)452-66.
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Score: 0.686 |
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Hepatitis C virus envelope proteins regulate CHOP via induction of the unfolded protein response.
- Shiu-Wan Chan ... Philip Anthony Egan
- FASEB J 2005 Sep; 19(11)1510-2.
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Score: 0.685 |
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Hepatitis C virus non-structural protein NS4B can modulate an unfolded protein response.
- Yi Zheng ... Linbai Ye
- J Microbiol 2005 Dec; 43(6)529-36.
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Score: 0.683 |
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The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein.
- C Caspersen ... M Treiman
- J Biol Chem 2000 Jul; 275(29)22363-72.
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Score: 0.683 |
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Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway.
- K Mori ... T Yura
- Genes Cells 1996 Sep; 1(9)803-17.
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Score: 0.680 |
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Spreading depression activates unfolded protein response.
- Edda Schneeloch ... Wulf Paschen
- Neurosci Lett 2004 Sep; 368(1)37-40.
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Score: 0.678 |
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Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.
- Gaetano Vattemi ... Valerie Askanas
- Am J Pathol 2004 Jan; 164(1)1-7.
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Score: 0.678 |
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A genetic link between the unfolded protein response and vesicle formation from the endoplasmic reticulum.
- Hironori Higashio ... Kenji Kohno
- Biochem Biophys Res Commun 2002 Aug; 296(3)568-74.
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Score: 0.678 |
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Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response.
- T Kawahara ... K Mori
- Mol Biol Cell 1997 Oct; 8(10)1845-62.
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Score: 0.674 |
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High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin.
- Jenny R Allen ... Fumihiko Urano
- Biochem Biophys Res Commun 2004 Nov; 324(1)166-70.
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Score: 0.674 |
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Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast.
- K Okamura ... K Kohno
- Biochem Biophys Res Commun 2000 Dec; 279(2)445-50.
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Score: 0.674 |
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A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.
- K Mori ... J F Sambrook
- EMBO J 1992 Jul; 11(7)2583-93.
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Score: 0.671 |
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IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast.
- Martin Schröder ... Randal J Kaufman
- Mol Microbiol 2003 Aug; 49(3)591-606.
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Score: 0.670 |
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IRE1 and efferent signaling from the endoplasmic reticulum.
- F Urano ... D Ron
- J Cell Sci 2000 Nov; 113 Pt 21()3697-702.
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Score: 0.669 |
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The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane.
- J S Cox ... P Walter
- Mol Biol Cell 1997 Sep; 8(9)1805-14.
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Score: 0.667 |
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Caspase-12 and ER-stress-mediated apoptosis: the story so far.
- Eva Szegezdi ... Afshin Samali
- Ann N Y Acad Sci 2003 Dec; 1010()186-94.
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Score: 0.664 |
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Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana.
- Shinya Kamauchi ... Reiko Urade
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Score: 0.663 |
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Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response.
- C Jousse ... P Fafournoux
- FEBS Lett 1999 Apr; 448(2-3)211-6.
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Score: 0.660 |
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Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death.
- Cole M Haynes ... Antony A Cooper
- Mol Cell 2004 Sep; 15(5)767-76.
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Score: 0.658 |
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Salsolinol causing parkinsonism activates endoplasmic reticulum-stress signaling pathways in human dopaminergic SK-N-SH cells.
- Mohsen Kheradpezhouh ... Manuchair Ebadi
- Neurosignals 2003 Nov-Dec; 12(6)315-24.
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Score: 0.656 |
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