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Your submitted paragraph: Immunoglobulin (antibody) isotypes In humans and the higher mammals five classes of immunoglobulin have been defined: IgG, IgM, IgA, IgD, and IgE and additionally, in humans, four subclasses of IgG and two subclasses of IgA. Since immunoglobulins of each class and subclass are present in all normal individuals they are referred to as isotypes (as distinct from the immunoglobulin ALLOTYPES and IDIOTYPES). The five different classes are determined by the type of heavy chain involved (termed g, m, a, d, and e respectively). Originally distinguished by immunological criteria (i.e. as distinct antigens), each isotype was later shown to be characterized by its amino-acid sequence and to be the product of a different gene segment (C genes, see IMMUNOGLOBULIN GENES).

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