 |
 |
- Constant and variable regions In the 1960s it became appreciated that BENCE-JONES PROTEIN, excreted in the urine of patients with multiple MYELOMA, represents an overproduction of light chain by the malignant clone of cells. Consequently it was homogeneous and readily purified for structural analysis. Sequence analysis of Bence-Jones protein from different individuals revealed that amongst k chains the amino-acid sequence of the N- terminal 110 residues was always different whereas the sequence of the C- terminal 110 residues was constant. These regions or domains were therefore termed the variable (V) region (in this case Vk) and the constant (C) region (Ck); l chains are similarly composed of V and C regions. Comparison of the sequences of heavy chains of the same isotype showed that they also comprised a variable N-terminal region of 110 amino-acid residues whereas the remainder of the sequence is constant and defines the isotype (Fig. A40a). Minor sequence differences between the C regions of immunoglobulins of the same isotype from different individuals allow the definition of allotypes (allelic variants of each C gene), first defined serologiclly using ALLOANTISERA.
Extraction Method: Medical Objects-
Eliminated words list: MedlinePlus List
-
Similarity Method: Keyword Count
-
Database: Medline abstracts
Publication Type: All
Score Calculation Method: Cosine Similarity Method
Sort by: Score
Show: Top 100 hits
Results computed on: 6/9/2006
A service of UT Southwestern Computational Biology Group
Copyright © 2001 - 2005