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Microsome-mediated bioactivation of dibenzo[a,l]pyrene and identification of DNA adducts by 32P-postlabeling. J M Arif ... R C Gupta Carcinogenesis 1997 Oct; 18(10)1999-2007. Score: 0.430

Your submitted paragraph: Action of chemical carcinogens Most known chemical carcinogens react chemically with DNA, either directly or as derivatives produced by metabolic activation to chemically reactive electrophilic species, which can then form covalent adducts [2]. Reaction typically occurs with the phosphate groups as well as with the DNA bases themselves. The ring nitrogen atoms of purines are the most reactive. Interactions have been documented at N2, N3, O6, N7, and C8 of guanine; N1, N3, N6, and N7 of adenine; O2, N3, N4, and C5 of cytosine; and O2 and O4 of thymine (see NUCLEOSIDES AND NUCLEOTIDES). In general there are high correlations between extent of adduct formation and carcinogenicity. PAHsin particular produce a complex mixture of adducts. In many cases these adducts, as well as unreacted products of metabolism, have been separated by chromatographic techniques and characterized by spectroscopic and chemical methods. In vitro and in vivo studies with these metabolic products have enabled the `ultimate carcinogens' to be identified for a number of carcinogens.

TRITE Statistics: Extraction Method: Medical Objects Eliminated words list: MedlinePlus List Similarity Method: Keyword Count Database: Medline abstracts Publication Type: All Score Calculation Method: Cosine Similarity Method Sort by: Score Show: Top 100 hits Results computed on: 6/9/2006

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