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- receptor-mediated endocytosis ENDOCYTOSIS of extracellular ligands in membrane-bounded vesicles following the binding of ligand to specific cell- surface RECEPTORS. Ligand binding at the cell surface increases the efficiency of endocytosis compared with nonadsorptive fluid phase endocytosis. ligands internalized by receptor- mediated endocytosis include nutrients (e.g. low density lipoprotein and transferrin), GROWTH FACTORS (e.g. epidermal growth factor and platelet- derived growth factor), polypeptide hormones (e.g. INSULIN), molecules to be cleared from the extracellular medium (e.g. a2-macroglobulin-protease complexes and secreted lysosomal hydrolases) and opportunistic ligands such as viruses and toxins. Uptake usually occurs through clathrin- coated pits and coated vesicles (see COATED PITS AND VESICLES), and frequently the receptors involved are able to interact with components of the clathrin coat to facilitate their uptake. The term can also apply to other forms of endocytosis involving receptor-ligand complexes, including phagocytosis, but generally refers to endocytosis through coated pits.
Extraction Method: Medical Objects-
Eliminated words list: MedlinePlus List
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Database: Medline abstracts
Publication Type: All
Score Calculation Method: Cosine Similarity Method
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Results computed on: 6/9/2006
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