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- mismatch repair Although the enzyme complex responsible for DNA REPLICATION has mechanisms of self-correction, a low level of errors remain in newly replicated DNA. This error rate, ~1 bp per 108 bp replicated or ~50 errors per Escherichia coli chromosome, is reduced by postreplication correction to ~1 bp per 1010. The study of MUTATOR strains, that is strains with high rates of spontaneous mutations, has led to the identification of these corrective mechanisms. The postreplication repair of mismatched base pairs has much in common with the repair of DNA damaged by ultraviolet light or DNA -reactive chemicals (see CHEMICAL CARCINOGENS AND CARCINOGENESIS; DNA REPAIR). The strand carrying the `wrong base' is cut and degraded to create a gap which is filled in by DNA polymerase I and the final link made by DNA LIGASE (see EXCISION REPAIR). Mismatch repair also affects the outcome of genetic RECOMBINATION and mutant strains with a defect in this form of repair show increased levels of recombination.
Extraction Method: Medical Objects-
Eliminated words list: MedlinePlus List
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Database: Medline abstracts
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