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Your submitted paragraph: Protein folding THE biological activity of a protein depends on its folding into a highly organized three-dimensional structure under physiological conditions. The central questions of protein folding are: 1 Why does it occur? What are the forces that make a well-defined conformation thermodynamically favourable? 2 How does it occur? What mechanisms permit rapid and efficient self- organization? 3 How is the 3-D structure encoded by the amino-acid sequence? These issues are, of course, intimately related and the goal of applying the principles of folding to, for example, predict structures from sequence or to design sequences compatible with particular structures (and functions?) (see PROTEIN ENGINEERING) is likely to require a broad understanding of each. At present there is still some way to go towards this objective but folding is the subject of intensive study.

TRITE Statistics: Extraction Method: Medical Objects Eliminated words list: MedlinePlus List Similarity Method: Keyword Count Database: Medline abstracts Publication Type: All Score Calculation Method: Cosine Similarity Method Sort by: Score Show: Top 100 hits Results computed on: 6/9/2006

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