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- Transfer ribonucleic acid (tRNA) TRANSFER RNA (tRNA) is a family of small nucleic acids that mediate the translation of the nucleic acid code into the amino-acid sequence of a protein (see GENETIC CODE; PROTEIN SYNTHESIS). Trying to understand how the nucleotide sequence of a messenger RNA could be translated into an amino acid led to the hypothesis, formulated by Francis Crick, that an adaptor molecule was needed which matched the CODON in mRNA to its particular amino acid [1]. Small ribonucleic acids were isolated, with two major properties: they could recognize a codon in mRNA and could also able to bind the amino acid corresponding to that codon. The main function of tRNAs is to carry amino acids to the RIBOSOMES and to incorporate the correct amino acid into the nascent protein chain. The pool of tRNAs can be subdivided in 20 subsets, each one specific for a given amino acid. tRNAs that specify the same amino acid are named isoacceptors.
Extraction Method: Medical Objects-
Eliminated words list: MedlinePlus List
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Similarity Method: Keyword Count
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Database: Medline abstracts
Publication Type: All
Score Calculation Method: Cosine Similarity Method
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Show: Top 100 hits
Results computed on: 6/9/2006
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