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Your submitted paragraph: Okazaki fragment A short fragment of DNA generated on the lagging strand during DNA REPLICATION. Because DNA polymerase can only elongate a polynucleotide strand in a 53 direction, a new DNA strand has to be synthesized discontinuously along one of the strands of the unwound duplex at the replication fork. Each Okazaki fragment is initiated as a short RNA primer and is 1000-2000 nucleotides long in prokaryotes, and 100-200 nucleotides long in eukaryotes. The gaps between fragments are subsequently filled in by DNA polymerase and joined by DNA ligase.

TRITE Statistics: Extraction Method: Medical Objects Eliminated words list: MedlinePlus List Similarity Method: Keyword Count Database: Medline abstracts Publication Type: All Score Calculation Method: Cosine Similarity Method Sort by: Score Show: Top 100 hits Results computed on: 6/9/2006

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