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Your submitted paragraph: Chemical carcinogens and carcinogenesis A CAUSAL link between a human cancer and a chemical agent in the environment was first reported in 1775 by the surgeon Percival Pott, who deduced a relationship between the high incidence of scrotal cancer in chimney sweeps and their exposure to soot. Studies in the early decades of this century established that the active constituents of soot and coal tar are POLYCYCLIC AROMATIC HYDROCARBONS. In 1964, Brookes and Lawley showed that when applied to mouse skin, polycyclic aromatic hydrocarbons become covalently bound to DNA, with the extent of binding correlating with carcinogenic potency. This experiment was a key element in support of the somatic mutation theory of cancer, and provided the impetus for many subsequent studies on the molecular basis of chemical carcinogenesis.

TRITE Statistics: Extraction Method: Medical Objects Eliminated words list: MedlinePlus List Similarity Method: Keyword Count Database: Medline abstracts Publication Type: All Score Calculation Method: Cosine Similarity Method Sort by: Score Show: Top 100 hits Results computed on: 6/9/2006

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